Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Björn, Frendéus"'
Autor:
Vivian Changying Jiang, Yang Liu, Alexa Jordan, Angela Leeming, Joseph McIntosh, Shengjian Huang, Rongjia Zhang, Qingsong Cai, Zhihong Chen, Yijing Li, Yuxuan Che, Lei Nie, Ingrid Karlsson, Linda Mårtensson, Mathilda Kovacek, Ingrid Teige, Björn Frendéus, Michael Wang
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-7 (2022)
Abstract Inevitable relapses remain as the major therapeutic challenge in patients with mantle cell lymphoma (MCL) despite FDA approval of multiple targeted therapies and immunotherapies. Fc gamma receptors (FcγRs) play important roles in regulating
Externí odkaz:
https://doaj.org/article/9f67a31b108c4b628eddafeb215126c0
Autor:
Jenny Mattsson, Ludvig Ekdahl, Fredrik Junghus, Ram Ajore, Eva Erlandsson, Abhishek Niroula, Maroulio Pertesi, Björn Frendéus, Ingrid Teige, Björn Nilsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Efficient deconvolution of antibody targets is needed for phenotype-based discovery. Here, the authors investigate a deconvolution approach based on pooled CRISPR Cas9 to achieve 97% deconvolution success rate.
Externí odkaz:
https://doaj.org/article/6e2a5135b9de48a8b79f53b16495e80f
Autor:
Stephanie Trend, Jonatan Leffler, Ingrid Teige, Björn Frendéus, Allan G. Kermode, Martyn A. French, Prue H. Hart
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhib
Externí odkaz:
https://doaj.org/article/730a7797bff443ecb9e6d5fd21de5d1c
Autor:
Anne Ljungars, Carolin Svensson, Anders Carlsson, Elin Birgersson, Ulla-Carin Tornberg, Björn Frendéus, Mats Ohlin, Mikael Mattsson
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Phage display technology is a common approach for discovery of therapeutic antibodies. Drug candidates are typically isolated in two steps: First, a pool of antibodies is enriched through consecutive rounds of selection on a target antigen, and then
Externí odkaz:
https://doaj.org/article/f941af7d42634d9a9720fb3ac3455650
Autor:
Ahmed Ludvigsen Al-Mashhadi, Christian Bo Poulsen, Karin von Wachenfeldt, Anna-Karin Robertson, Jacob Fog Bentzon, Lars Bo Nielsen, Jesper Thygesen, Lars Poulsen Tolbod, Jens Rolighed Larsen, Søren Kragh Moestrup, Björn Frendéus, Brynjulf Mortensen, Ludovic Drouet, Rozh H. Al-Mashhadi, Erling Falk
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
Background. Obesity and metabolic syndrome (MetS) are major risk factors for atherosclerotic diseases; however, a causal link remains elusive. Animal models resembling human MetS and its complications, while important, are scarce. We aimed at develop
Externí odkaz:
https://doaj.org/article/2c21b3e715324ff9bbb4daf88ef55399
Autor:
Jenny Mattsson, Anne Ljungars, Anders Carlsson, Carolin Svensson, Björn Nilsson, Mats Ohlin, Björn Frendéus
Publikováno v:
Cell Reports Methods. 3:100475
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b58b54f5420156ae00c93a4f41211afd
https://doi.org/10.1016/j.crmeth.2023.100475
https://doi.org/10.1016/j.crmeth.2023.100475
Autor:
Björn Nilsson, Björn Frendéus, Eva Erlandsson, Maroulio Pertesi, Ingrid Teige, Abhishek Niroula, Jenny Mattsson, Ludvig Ekdahl, Fredrik Junghus, Ram Ajore
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications
Nature Communications
Therapeutic antibodies are transforming the treatment of cancer and autoimmune diseases. Today, a key challenge is finding antibodies against new targets. Phenotypic discovery promises to achieve this by enabling discovery of antibodies with therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbe886e3f1eab630bb3eed30348af9b
https://doaj.org/article/6e2a5135b9de48a8b79f53b16495e80f
https://doaj.org/article/6e2a5135b9de48a8b79f53b16495e80f
Autor:
Monika Semmrich, Jean-Baptiste Marchand, Laetitia Fend, Matilda Rehn, Christelle Remy, Petra Holmkvist, Nathalie Silvestre, Carolin Svensson, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Eric Quéméneur, Björn Frendéus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
BackgroundImmune checkpoint blockade (ICB) is a clinically proven concept to treat cancer. Still, a majority of patients with cancer including those with poorly immune infiltrated ‘cold’ tumors are resistant to currently available ICB therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422945ff6754e9a6ad3d2b4f27d8959c
https://jitc.bmj.com/content/10/1/e003488.full
https://jitc.bmj.com/content/10/1/e003488.full
Autor:
Monika, Semmrich, Jean-Baptiste, Marchand, Laetitia, Fend, Matilda, Rehn, Christelle, Remy, Petra, Holmkvist, Nathalie, Silvestre, Carolin, Svensson, Patricia, Kleinpeter, Jules, Deforges, Fred, Junghus, Kirstie L, Cleary, Mimoza, Bodén, Linda, Mårtensson, Johann, Foloppe, Ingrid, Teige, Eric, Quéméneur, Björn, Frendéus
Publikováno v:
Journal for Immunotherapy of Cancer
Background Immune checkpoint blockade (ICB) is a clinically proven concept to treat cancer. Still, a majority of patients with cancer including those with poorly immune infiltrated ‘cold’ tumors are resistant to currently available ICB therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09bd94ed6325ee24b261cd0627e28c52
https://pubmed.ncbi.nlm.nih.gov/35058324
https://pubmed.ncbi.nlm.nih.gov/35058324
Autor:
Vivian Changying Jiang, Yang Liu, Alexa Jordan, Angela Leeming, Joseph McIntosh, Shengjian Huang, Rongjia Zhang, Qingsong Cai, Zhihong Chen, Yijing Li, Yuxuan Che, Lei Nie, Ingrid Karlsson, Linda Mårtensson, Mathilda Kovacek, Ingrid Teige, Björn Frendéus, Michael Wang
Publikováno v:
Journal of hematologyoncology. 15(1)
Abstract Inevitable relapses remain as the major therapeutic challenge in patients with mantle cell lymphoma (MCL) despite FDA approval of multiple targeted therapies and immunotherapies. Fc gamma receptors (FcγRs) play important roles in regulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe53e3965c7a3baa511508b502741613
https://pubmed.ncbi.nlm.nih.gov/35410313
https://pubmed.ncbi.nlm.nih.gov/35410313