Peptide analogs that inhibit IgE-Fc epsilon RI alpha interactions ameliorate the development of lethal graft-versus-host disease

Autor: Korngold R, Ba, Jameson, Jm, Mcdonnell, Leighton C, Bj, Sutton, Hannah Gould, Gf, Murphy

Publikováno v: Europe PubMed Central

Significant increases in serum levels of IgE have often been observed in allogeneic bone marrow transplantation patients and have generally been thought to be diagnostic of graft-versus-host disease (GVHD), rather than an agent involved in the pathog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eff200076ef785244f523122cef6e8bf
https://pubmed.ncbi.nlm.nih.gov/9360780

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

Autor: Hussein D, Starr A, Heikal L, McNeill E, keith channon, Pr, Brown, Bj, Sutton, Jm, Mcdonnell, Nandi M

Publikováno v: Europe PubMed Central
Hussein, D A A, Starr, A, Heikal, L, McNeill, E, Channon, K M, Brown, P R, Sutton, B J, McDonnell, J M & Nandi, M 2015, ' Validating the GTP cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches. ', British journal of pharmacology, vol. 172, no. 16, pp. 4146-4157 . https://doi.org/10.1111/bph.13202
British Journal of Pharmacology

Background and Purpose 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients. Unfortunately, oral BH4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b2569f6f866c2287491a15d3f7c7d9aa
http://europepmc.org/abstract/med/26014146

Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor.

Autor: Vester SK; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK., Davies AM; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK., Beavil RL; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK., Sandhar BS; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK., Beavil AJ; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK., Gould HJ; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK., Sutton BJ; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK., McDonnell JM; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.

Publikováno v: Antibodies (Basel, Switzerland) [Antibodies (Basel)] 2023 Nov 16; Vol. 12 (4). Date of Electronic Publication: 2023 Nov 16.

Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.

Autor: Davies AM; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, London SE1 1UL, United Kingdom., Beavil RL; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, London SE1 1UL, United Kingdom., Barbolov M; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, London SE1 1UL, United Kingdom., Sandhar BS; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, London SE1 1UL, United Kingdom., Gould HJ; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, London SE1 1UL, United Kingdom., Beavil AJ; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, London SE1 1UL, United Kingdom., Sutton BJ; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, London SE1 1UL, United Kingdom., McDonnell JM; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, London SE1 1UL, United Kingdom. Electronic address: james.mcdonnell@kcl.ac.uk.

Publikováno v: Molecular immunology [Mol Immunol] 2023 Jul; Vol. 159, pp. 28-37. Date of Electronic Publication: 2023 Jun 01.

Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.

Autor: Ilkow VF; Randall Centre for Cell & Molecular Biophysics, King's College London, UK.; Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Davies AM; Randall Centre for Cell & Molecular Biophysics, King's College London, UK.; Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Dhaliwal B; Randall Centre for Cell & Molecular Biophysics, King's College London, UK.; Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Beavil AJ; Randall Centre for Cell & Molecular Biophysics, King's College London, UK.; Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Sutton BJ; Randall Centre for Cell & Molecular Biophysics, King's College London, UK.; Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., McDonnell JM; Randall Centre for Cell & Molecular Biophysics, King's College London, UK.; Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.

Publikováno v: FEBS open bio [FEBS Open Bio] 2021 Jul; Vol. 11 (7), pp. 1827-1840. Date of Electronic Publication: 2021 Jun 24.