A clonal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals

Autor: Mj, Garlepp, Ah, Rose, Rv, Bowman, Nasim Mavaddat, Dench J, Bj, Holt, Baron-Hay M, Pg, Holt, Bw, Robinson

Publikováno v: Europe PubMed Central

The characteristics of the T-cell population in the healthy human lung have been investigated by analysing the properties of T-cell clones derived from bronchoalveolar lavage (BAL) samples and comparing them with T cells cloned from the blood of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f3d2559cb49c68ff81427244b2ef901e
https://pubmed.ncbi.nlm.nih.gov/1356914

Lipopolysaccharide-induced interferon response networks at birth are predictive of severe viral lower respiratory infections in the first year of life.

Autor: Read JF; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; School of Medicine, The University of Western Australia, Nedlands, WA, Australia., Serralha M; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Mok D; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Holt BJ; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Cruickshank M; School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia., Karpievitch YV; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia., Broadhurst DI; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Joondalup, WA, Australia., Sly PD; Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia., Strickland DH; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; The University of Western Australia Centre for Child Health Research, The University of Western Australia, Nedlands, WA, Australia., Reinke SN; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Joondalup, WA, Australia., Holt PG; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; The University of Western Australia Centre for Child Health Research, The University of Western Australia, Nedlands, WA, Australia., Bosco A; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; The University of Western Australia Centre for Child Health Research, The University of Western Australia, Nedlands, WA, Australia.; Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, United States.; Department of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Aug 05; Vol. 13, pp. 876654. Date of Electronic Publication: 2022 Aug 05 (Print Publication: 2022).

Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.

Autor: Huang QQ; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. qh1@sanger.ac.uk.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, 3010, Australia. qh1@sanger.ac.uk.; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK. qh1@sanger.ac.uk., Tang HHF; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; School of BioSciences, The University of Melbourne, Parkville, VIC, 3010, Australia., Teo SM; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Mok D; Telethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia., Ritchie SC; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Nath AP; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Brozynska M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Salim A; Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, 3010, Australia.; Melbourne School of Population and Global Health, Carlton, VIC, 3053, Australia., Bakshi A; Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia., Holt BJ; Telethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia., Khor CC; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.; Singapore Eye Research Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Sly PD; Child Health Research Centre, The University of Queensland, Brisbane, QLD, 4101, Australia., Holt PG; Telethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia.; Child Health Research Centre, The University of Queensland, Brisbane, QLD, 4101, Australia., Holt KE; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.; The London School of Hygiene and Tropical Medicine, London, WC1E 7TH, UK., Inouye M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. minouye@baker.edu.au.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, 3010, Australia. minouye@baker.edu.au.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. minouye@baker.edu.au.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. minouye@baker.edu.au.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK. minouye@baker.edu.au.; The Alan Turing Institute, London, UK. minouye@baker.edu.au.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK. minouye@baker.edu.au.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. minouye@baker.edu.au.

Publikováno v: Nature communications [Nat Commun] 2020 Jul 28; Vol. 11 (1), pp. 3761. Date of Electronic Publication: 2020 Jul 28.

Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis.

Autor: Jones AC; 1 Telethon Kids Institute and.; 2 School of Medicine, The University of Western Australia, Nedlands, Western Australia, Australia; and., Anderson D; 1 Telethon Kids Institute and., Galbraith S; 3 Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia., Fantino E; 3 Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia., Gutierrez Cardenas D; 3 Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia., Read JF; 1 Telethon Kids Institute and.; 2 School of Medicine, The University of Western Australia, Nedlands, Western Australia, Australia; and., Serralha M; 1 Telethon Kids Institute and., Holt BJ; 1 Telethon Kids Institute and., Strickland DH; 1 Telethon Kids Institute and., Sly PD; 3 Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia., Bosco A; 1 Telethon Kids Institute and., Holt PG; 1 Telethon Kids Institute and.; 3 Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Jun 15; Vol. 199 (12), pp. 1537-1549.

Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.

Autor: Teo SM; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Tang HHF; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; School of BioSciences, The University of Melbourne, Parkville, VIC 3010, Australia., Mok D; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Judd LM; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Watts SC; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Pham K; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia., Holt BJ; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Kusel M; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Serralha M; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Troy N; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Bochkov YA; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Grindle K; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Lemanske RF Jr; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Johnston SL; Airway Disease Infection Section and MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK., Gern JE; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Sly PD; Child Health Research Centre, The University of Queensland, Brisbane 4101, Australia., Holt PG; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; Child Health Research Centre, The University of Queensland, Brisbane 4101, Australia., Holt KE; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; The London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. Electronic address: kholt@unimelb.edu.au., Inouye M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; School of BioSciences, The University of Melbourne, Parkville, VIC 3010, Australia; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia; The Alan Turing Institute, London, UK. Electronic address: mi336@medschl.cam.ac.uk.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2018 Sep 12; Vol. 24 (3), pp. 341-352.e5.