Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Biva M. Desai"'
Autor:
Pamela A. Haile, Linda N. Casillas, Bartholomew J. Votta, Gren Z. Wang, Adam K. Charnley, Xiaoyang Dong, Michael J. Bury, Joseph J. Romano, John F. Mehlmann, Bryan W. King, Karl F. Erhard, Charles R. Hanning, David B. Lipshutz, Biva M. Desai, Carol A. Capriotti, Michelle C. Schaeffer, Scott B. Berger, Mukesh K. Mahajan, Michael A. Reilly, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, John K. Kenna, Allison M. Beal, Michael T. Ouellette, Mike Kelly, Gillian Stemp, Máire A. Convery, Anna Vossenkämper, Thomas T. MacDonald, Peter J. Gough, John Bertin, Robert W. Marquis
Publikováno v:
Journal of Medicinal Chemistry. 62:6482-6494
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaccf9e5808f38c133e85649c11ad3f1
https://doi.org/10.1021/acs.jmedchem.9b00575
https://doi.org/10.1021/acs.jmedchem.9b00575
Autor:
Pamela A, Haile, Linda N, Casillas, Bartholomew J, Votta, Gren Z, Wang, Adam K, Charnley, Xiaoyang, Dong, Michael J, Bury, Joseph J, Romano, John F, Mehlmann, Bryan W, King, Karl F, Erhard, Charles R, Hanning, David B, Lipshutz, Biva M, Desai, Carol A, Capriotti, Michelle C, Schaeffer, Scott B, Berger, Mukesh K, Mahajan, Michael A, Reilly, Rakesh, Nagilla, Elizabeth J, Rivera, Helen H, Sun, John K, Kenna, Allison M, Beal, Michael T, Ouellette, Mike, Kelly, Gillian, Stemp, Máire A, Convery, Anna, Vossenkämper, Thomas T, MacDonald, Peter J, Gough, John, Bertin, Robert W, Marquis
Publikováno v:
Journal of medicinal chemistry. 62(14)
RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. Small-molecule inhibitors of RIP2 kinase or its signaling partne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ceb97ed99e9c95859d4d1b3bee6fd6c8
https://pubmed.ncbi.nlm.nih.gov/31265286
https://pubmed.ncbi.nlm.nih.gov/31265286
Autor:
Elizabeth J. Rivera, Brian Donovan, Ami S. Lakdawala, Nikolay V. Plotnikov, Xiaoyang Dong, Barry S. Brown, Robert Singhaus, Khuram W. Chaudhary, Rachel D. Totoritis, Adam Kenneth Charnley, Michael Reilly, Terry Vincent Hughes, Joseph J. Romano, Pamela A. Haile, Robert W. Marquis, Michael Jonathan Bury, John F. Mehlmann, Gren Z. Wang, Rakesh Nagilla, Bartholomew J. Votta, Barbara A. Swift, Linda N. Casillas, Demartino Michael P, Peter J. Gough, Mukesh K. Mahajan, Carol A. Capriotti, Biva M. Desai, Scott B. Berger, Carol LePage, Helen H. Sun, David B. Lipshutz, John Bertin, Máire A. Convery, Chaya Duraiswami, Michael T. Ouellette
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1353-1353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86fc583fc629ca7da33971d5c6863f9b
https://doi.org/10.1021/acsmedchemlett.0c00260
https://doi.org/10.1021/acsmedchemlett.0c00260
Autor:
Rachel D. Totoritis, Robert Singhaus, Brian Donovan, Nikolay V. Plotnikov, John F. Mehlmann, Terry Vincent Hughes, Michael Jonathan Bury, Pamela A. Haile, Khuram W. Chaudhary, Gren Z. Wang, Peter J. Gough, Biva M. Desai, Michael T. Ouellette, Michael Reilly, Mukesh K. Mahajan, Barry S. Brown, Scott B. Berger, Xiaoyang Dong, Carol A. Capriotti, Carol LePage, Bartholomew J. Votta, Helen H. Sun, David B. Lipshutz, John Bertin, Joseph J. Romano, Adam Kenneth Charnley, Ami S. Lakdawala, Robert W. Marquis, Barbara A. Swift, Rakesh Nagilla, Máire A. Convery, Demartino Michael P, Elizabeth J. Rivera, Linda N. Casillas
Publikováno v:
ACS Med Chem Lett
[Image: see text] RIP2 kinase was recently identified as a therapeutic target for a variety of autoimmune diseases. We have reported previously a selective 4-aminoquinoline-based RIP2 inhibitor GSK583 and demonstrated its effectiveness in blocking do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8905a378b661333d1e52909683d43cfc
https://pubmed.ncbi.nlm.nih.gov/32551024
https://pubmed.ncbi.nlm.nih.gov/32551024
Publikováno v:
Pediatric Research. 66:42-46
Intrauterine growth restriction (IUGR) induced by uterine artery ligation in pregnant rats leads to low birth weight and early insulin secretory defects followed by the development of insulin resistance, decline in beta-cell mass, and diabetes in adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47713da11566e2c2cf94923500fd201
https://doi.org/10.1203/pdr.0b013e3181a282a5
https://doi.org/10.1203/pdr.0b013e3181a282a5
Publikováno v:
Molecular and Cellular Biology. 24:4372-4383
Hox factors are evolutionarily conserved homeodomain-containing transcription factors that are critical for the determination of the body plan during early development and for the regulation of key differentiation-specific genes that determine cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b0dcb8e09ad3a7d1882de421908a72
https://doi.org/10.1128/mcb.24.10.4372-4383.2004
https://doi.org/10.1128/mcb.24.10.4372-4383.2004
Publikováno v:
Diabetes. 52:734-740
Uteroplacental insufficiency resulting in fetal growth retardation is a common complication of pregnancy and a significant cause of perinatal morbidity and mortality. Epidemiological studies show an increased incidence of type 2 diabetes in humans wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe920ccfafa129fa8d33135307944be
https://doi.org/10.2337/diabetes.52.3.734
https://doi.org/10.2337/diabetes.52.3.734
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration
Autor:
Diva D. De León, Nankang Hong, Doris A. Stoffers, Steven D. Leach, Cyrus Farzad, Jennifer Oliver-Krasinski, Biva M. Desai
Publikováno v:
The Journal of clinical investigation. 117(4)
It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic efforts to increase insulin-producing beta cell mass in patients with diabetes. We report what
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf57436ca50dcdaa92da0ff354ce453
https://pubmed.ncbi.nlm.nih.gov/17404611
https://pubmed.ncbi.nlm.nih.gov/17404611
Autor:
Linda N. Casillas, Carol A. Capriotti, Bart Votta, Kevin Foley, Peter J. Gough, Michael Reilly, Barbara A. Swift, Robert W. Marquis, Pamela A. Haile, David B. Lipshutz, Biva M. Desai, John Bertin, Thomas T. MacDonald, Paolo Biancheri, Anna Vossenkämper
Publikováno v:
Gastroenterology. 142:S-878
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c053b275e2f6cddac112f62c1f79fc3
https://doi.org/10.1016/s0016-5085(12)63408-8
https://doi.org/10.1016/s0016-5085(12)63408-8
Autor:
P J Gough, Kevin Foley, Liping Wang, Carlos D. Rose, Pamela A. Haile, Bartholomew J. Votta, M Miller, Anna Vossenkämper, Michael Reilly, Paolo Biancheri, J Connor, Carine Wouters, Thomas T. MacDonald, David B. Lipshutz, Linda N. Casillas, John Bertin, Biva M. Desai
Publikováno v:
Pediatric Rheumatology Online Journal
Blau Syndrome (Blau) is a granulomatous auto-inflammatory disease caused by mutations in NOD2 that have been proposed to result in phosphorylation of RIP2 kinase and the production of pro-inflammatory cytokines. Such monogenic diseases can bring to l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefb36a672f5c3a48cfa1dc82cf98a11