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A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits.

Autor: Wietek J; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Nozownik A; Center for Molecular Neurobiology, Hamburg, Germany.; Present address: Paris Brain Institute, Institut du Cerveau (ICM), CNRS UMR 7225, INSERM U1127, Sorbonne Université, Paris, France., Pulin M; Center for Molecular Neurobiology, Hamburg, Germany.; Present address: Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Saraf-Sinik I; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Matosevich N; Sagol school of neuroscience, Tel Aviv University, Tel Aviv, Israel., Malan D; Institut für Physiologie I, Universität Bonn, Bonn, Germany., Brown BJ; Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA., Dine J; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.; Present address: Boehringer Ingelheim Pharma GmbH & Co. KG; CNS Diseases, Biberach an der Riss, Germany., Levy R; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Litvin A; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Regev N; Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel., Subramaniam S; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Bitton E; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Benjamin A; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Copits BA; Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA., Sasse P; Institut für Physiologie I, Universität Bonn, Bonn, Germany., Rost BR; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Neuroscience Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany., Schmitz D; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Neuroscience Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Bernstein Center for Computational Neuroscience, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Berlin, Germany.; Max-Delbrück Center for Molecular Medicine, Berlin, Germany., Soba P; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; LIMES-Institute, University of Bonn, Bonn, Germany., Nir Y; Sagol school of neuroscience, Tel Aviv University, Tel Aviv, Israel.; Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel.; Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel., Wiegert JS; Center for Molecular Neurobiology, Hamburg, Germany.; Present address: MCTN, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany., Yizhar O; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 02. Date of Electronic Publication: 2023 Jul 02.