Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bithika Dhar"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Guanine nucleotide exchange factors (GEFs) are a family of proteins that modulate small G protein signaling. Mutations in a subfamily of GEFs that act on Rap, known as RapGEFs, have been associated with neurological disorders, and knockout mice displ
Externí odkaz:
https://doaj.org/article/c160d5463e0c4cdb961143ce9277899b
Autor:
David Rios-Covian, Lindsay D. Butcher, Amber L. Ablack, Gerco den Hartog, Mason T. Matsubara, Hong Ly, Andrew W. Oates, Guorong Xu, Kathleen M. Fisch, Eric T. Ahrens, Shusuke Toden, Corrie C. Brown, Kenneth Kim, Dzung Le, Lars Eckmann, Bithika Dhar, Tadahide Izumi, Peter B. Ernst, Sheila E. Crowe
While best known for its role in oxidative DNA damage repair, apurinic-apyrimidinic endonuclease-1 (APE1) is a multifunctional protein that regulates multiple host responses during oxidative stress including the reductive activation of transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe004c4f6c31b2bf57a0dc06964a1723
http://hdl.handle.net/10029/625917
http://hdl.handle.net/10029/625917
Autor:
David, Rios-Covian, Lindsay D, Butcher, Amber L, Ablack, Gerco, den Hartog, Mason T, Matsubara, Hong, Ly, Andrew W, Oates, Guorong, Xu, Kathleen M, Fisch, Eric T, Ahrens, Shusuke, Toden, Corrie C, Brown, Kenneth, Kim, Dzung, Le, Lars, Eckmann, Bithika, Dhar, Tadahide, Izumi, Peter B, Ernst, Sheila E, Crowe
Publikováno v:
Antioxidantsredox signaling.
Autor:
Nathaniel Holcomb, Bithika Dhar, Hong Pu, Robert-Marlo Bautista, Anna Heink Overmann, Lauren Corum, Brent Shelton, John D’Orazio
Although mismatch repair (MMR) defects are associated with high risk of malignancy, the specific oncogenic drivers pertinent to MMR-affected cancers are poorly characterized. The heterozygous ATR-I774Yfs*5 mutation, the result of strand slippage in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e23ec3137e49f411ae582bf3f2e74a4d
https://doi.org/10.1101/2022.03.10.483800
https://doi.org/10.1101/2022.03.10.483800
Autor:
Bithika Dhar, Jing Chen, Daret K. St. Clair, Haining Zhu, Vasudevan Bakthavatchalu, Tianyan Gao, Izumi Tadahide, Sanjit K. Dhar
Publikováno v:
Oncogene
Autophagy is a highly regulated evolutionarily conserved metabolic process induced by stress and energy deprivation. Here, we show that DNA polymerase gamma (Polγ) deficiency activates a selective prosurvival autophagic response via mitochondria-med
Autor:
Rangaswamy Suganya, Tadahide Izumi, Thomas Pittman, Craig Horbinski, Christina A. Wicker, Bithika Dhar, Timothy L. Scott
Publikováno v:
Molecular Carcinogenesis. 56:325-336
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial DNA. Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene, is an E3 ubi
Autor:
Timothy L, Scott, Christina A, Wicker, Rangaswamy, Suganya, Bithika, Dhar, Thomas, Pittman, Craig, Horbinski, Tadahide, Izumi
Publikováno v:
Molecular carcinogenesis. 56(2)
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial DNA. Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene, is an E3 ubi
Autor:
Vasu Bakthavatchalu, Haining Zhu, Jing Chen, Izumi Tadahide, Bithika Dhar, Daret K. St. Clair, Sanjit K. Dhar
Publikováno v:
Free Radical Biology and Medicine. 87:S65
Autor:
Suganya Rangaswamy, Bithika Dhar, Timothy L. Scott, Hansruedi Büeler, Lianteng Zhi, Tadahide Izumi
Publikováno v:
Cancer Research. 73:622-622
The mammalian apurinic/apyrimidinic endonuclease 1 (APE1/Ref1) is a DNA repair/redox regulator protein of which cytoplasmic accumulation has been associated with tumorigenesis and poor survival outcome. APE1 is degraded through the ubiquitin/proteaso