Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Biswanath De"'
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 12, Pp o3465-o3466 (2011)
In the title compound, C22H24N4O, the aromatic moiety is essentially planar (r.m.s. deviation of a least-squares plane fitted through all non-H atoms = 0.0386 Å) and is rotated by 89.98 (4)° from the piperazine ring, which adopts the expected chair
Externí odkaz:
https://doaj.org/article/44ba02db70724577b6dc122a99cfdf76
Autor:
Laurence H. Hurley, Cindy K. Miranti, Elsa M. Reyes-Reyes, Venkateshwar Reddy Chappeta, Vijay Gokhale, Yongeun Kim, Biswanath De, Kui Wu, Sara Moore
Publikováno v:
Oncotarget
The androgen receptor (AR) is a major driver of prostate cancer development and progression. Men who develop advanced prostate cancer often have long-term cancer control when treated with androgen-deprivation therapies (ADT). Still, their disease ine
Autor:
Cindy K. Miranti, Yongeun Kim, Elsa M. Reyes-Reyes, Biswanath De, Laurence H. Hurley, Sara Moore, Vijay Gokhale, Venkateshwar Reddy Chappeta, Kui Wu
Publikováno v:
Oncotarget. 11:2586-2586
Autor:
Steven V. O’Neil, Biswanath De, Christopher D. Ellis, Charles A. Cruze, Mark William Baize, Thomas P. Demuth, Laufersweiler Michael Christopher, Maria Buchalova, Wei Lu, Richard L. Wang, Marina Belkin, Amy N. Fancher, Maureen K. Suchanek, John August Wos, David Lindsey Soper, William P. Schwecke, Kofi A. Oppong, Yili Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:1311-1322
Peptidomimetic compounds possessing a caprolactam ring constraint were prepared and evaluated as interleukin-1beta converting enzyme (ICE) inhibitors. The caprolactam ring was used to constrain the P3 region of our inhibitors. This strategy proved to
Autor:
Todd A. Brugel, Vijayasurian Easwaran, Mark Sabat, John C. VanRens, Biswanath De, Artem G. Evdokimov, Adam Golebiowski, Jennifer A. Maier, R.L. Walter, Michael J. Janusz, Marlene Mekel, Matthew J. Laufersweiler, Lily C. Hsieh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5973-5977
This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a repres
Autor:
David Lindsey Soper, John August Wos, Kofi A. Oppong, Richard L. Wang, Biswanath De, Laufersweiler Michael Christopher, Thomas P. Demuth, Wei Lu, Steven V. O’Neil, Maureen K. Suchanek, Christopher D. Ellis, Amy N. Fancher, Yili Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4728-4732
A series of monocyclic thiazepine inhibitors of interleukin-1β converting enzyme (ICE) were synthesized in eight steps from commercially available intermediates. In vitro biological evaluation showed the thiazepines to be moderately potent ICE inhib
Autor:
Biswanath De, Michael J. Janusz, Vijayasurian Easwaran, Jennifer A. Maier, Todd A. Brugel, Matthew J. Laufersweiler, Corey R. Hopkins, Adam Golebiowski, Kimberly K. Brown, Mark Sabat, Lily C. Hsieh, John C. VanRens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3646-3650
A new class of lymphocyte specific tyrosine kinase (lck) inhibitors based on an N-4,6-pyrimidine-N-alkyl-N′-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar inhibition of lck kinase activity as well as IL-2 synthesis
Autor:
David R. Adams, Biswanath De, Vu P. Bui, Adam Golebiowski, Tomas Hudlicky, Mary Ann A. Endoma, Roger G. Bookland, Mark Sabat, Jennifer A. Maier, Michael P. Clark, Todd A. Brugel, Matthew J. Laufersweiler
Publikováno v:
Tetrahedron Letters. 47:3195-3198
Cyclization of various bisacylated hydrazines and pyrazolidines using DBU or sodium hydride leads to the formation of various mono-, bi- and tricyclic pyrazolone scaffolds in 41–98% yield. The convergent nature by which the precyclization intermedi
Autor:
Timothy R. Baker, Biswanath De, Michael J. Janusz, Sandra A. Heitmeyer, Stanislaw Pikul, Neil Gregory Almstead, Michael George Natchus, Y.O. Taiwo, Vikram S. Patel, Sean X. Peng, Kimberly K. Brown, E.B. Hookfin, Lily C. Hsieh
Publikováno v:
Inflammation Research. 55:60-65
Objective and Design: Hydroxamic-and carboxylic- acid based matrix metalloproteinase inhibitors (MMPIs) were compared for their potency against various MMPs, pharmacodynamic properties and in vivo efficacy in a model of cartilage degeneration. Materi
Autor:
Amy N. Fancher, Mark William Baize, Thomas P. Demuth, Kofi A. Oppong, Yili Wang, David Lindsey Soper, Steven V. O’Neil, Richard L. Wang, Wei Lu, Christopher D. Ellis, Maureen K. Suchanek, John August Wos, Gregory K. Bosch, Laufersweiler Michael Christopher, Biswanath De
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5434-5438
Two novel 8,6-fused bicyclic peptidomimetic ring systems were synthesized utilizing olefin metathesis as the key reaction for the formation of the eight-membered ring. Both peptidomimetic scaffolds were further elaborated into potent ICE inhibitors,