Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Bisrat G Debeb"'
Autor:
Arvind Bambhroliya, Renae D Van Wyhe, Swaminathan Kumar, Bisrat G Debeb, Jay P Reddy, Steve Van Laere, Randa El-Zein, Arvind Rao, Wendy A Woodward
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0192689 (2018)
Epidemiological studies have found that triple-negative breast cancer (TNBC) and TN inflammatory breast cancer (IBC) are associated with lower frequency and duration of breast-feeding compared to non-TNBC and non-TN IBC, respectively. Limited breast-
Externí odkaz:
https://doaj.org/article/efbff8ff0f33420eae9866eddb6bde68
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120719 (2015)
Survivin is a key member of the inhibitor of apoptosis protein family, and is considered a promising therapeutic target due to its universal overexpression in cancers. Survivin is implicated in cellular radiation response through its role in apoptosi
Externí odkaz:
https://doaj.org/article/9798f05873dc4ee89dc1c3f84fc91e84
Autor:
Simone Anfossi, Antonio Giordano, Hui Gao, Evan N Cohen, Sanda Tin, Qiong Wu, Raul J Garza, Bisrat G Debeb, Ricardo H Alvarez, Vicente Valero, Gabriel N Hortobagyi, George A Calin, Naoto T Ueno, Wendy A Woodward, James M Reuben
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83113 (2014)
Altered serum microRNA (miRNA) levels may be correlated with a dysregulated expression pattern in parental tumor tissue and reflect the clinical evolution of disease. The overexpression of miR-21, miR-10b, and miR-19a is associated with the acquisiti
Externí odkaz:
https://doaj.org/article/feaa701ac9bd409a824be6831dd824c3
Autor:
Wei Xu, Lara Lacerda, Bisrat G Debeb, Rachel L Atkinson, Travis N Solley, Li Li, Darren Orton, John S McMurray, Brian I Hang, Ethan Lee, Ann H Klopp, Naoto T Ueno, James M Reuben, Savitri Krishnamurthy, Wendy A Woodward
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71508 (2013)
WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved antihelmintic drug that inhibits WNT signaling, to test whether pharmacologic inhibition of WNT signal
Externí odkaz:
https://doaj.org/article/7271058255d14c78842fbbe8ff1956f3
Autor:
Ann H Klopp, Lara Lacerda, Anshul Gupta, Bisrat G Debeb, Travis Solley, Li Li, Erika Spaeth, Wei Xu, Xiaomei Zhang, Michael T Lewis, James M Reuben, Savitri Krishnamurthy, Mauro Ferrari, Rogério Gaspar, Thomas A Buchholz, Massimo Cristofanilli, Frank Marini, Michael Andreeff, Wendy A Woodward
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12180 (2010)
Normal and malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew, referred to as stem cells, or tumor initiating cells (TIC). These cells can be enriched by growth as "mammospheres" in three-dimensio
Externí odkaz:
https://doaj.org/article/bba69df0a669493d8baf734761d933a2
Autor:
Bisrat G Debeb, Vasiliy Galat, Jessica Epple-Farmer, Steve Iannaccone, Wendy A Woodward, Michael Bader, Philip Iannaccone, Bert Binas
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7216 (2009)
BACKGROUND:The extraembryonic endoderm (ExEn) defines the yolk sac, a set of membranes that provide essential support for mammalian embryos. Recent findings suggest that the committed ExEn precursor is present already in the embryonic Inner Cell Mass
Externí odkaz:
https://doaj.org/article/10edf17f0ba34d81a26eeac4549d618e
Autor:
Emilly S. Villodre, Xiaoding Hu, Richard Larson, Pascal Finetti, Kristen Gomez, Wintana Balema, Shane R. Stecklein, Ginette Santiago‐Sanchez, Savitri Krishnamurthy, Juhee Song, Xiaoping Su, Naoto T. Ueno, Debu Tripathy, Steven Van Laere, François Bertucci, Pablo Vivas‐Mejía, Wendy A. Woodward, Bisrat G. Debeb
Publikováno v:
Molecular Oncology, Vol 15, Iss 10, Pp 2752-2765 (2021)
Inflammatory breast cancer (IBC) is an aggressive form of primary breast cancer characterized by rapid onset and high risk of metastasis and poor clinical outcomes. The biological basis for the aggressiveness of IBC is still not well understood and n
Externí odkaz:
https://doaj.org/article/8e186a4924364ac4b8997f8fc8947ced
Autor:
Wintana Balema, Diane Liu, Yu Shen, Randa El‐Zein, Bisrat G. Debeb, Megumi Kai, Beth Overmoyer, Kathy D. Miller, Huong T. Le‐Petross, Naoto T. Ueno, Wendy A. Woodward
Publikováno v:
Cancer Medicine, Vol 10, Iss 18, Pp 6261-6272 (2021)
Abstract Background Inflammatory breast cancer (IBC) is a clinical diagnosis. Here, we examined the association of a “classic” triad of clinical signs, swollen involved breast, nipple change, and diffuse skin change, with overall survival (OS). M
Externí odkaz:
https://doaj.org/article/71742e0526d545248a9ccf667e9f4628
Autor:
Xiaoding Hu, Emilly S. Villodre, Richard Larson, Omar M. Rahal, Xiaoping Wang, Yun Gong, Juhee Song, Savitri Krishnamurthy, Naoto T. Ueno, Debu Tripathy, Wendy A. Woodward, Bisrat G. Debeb
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Xiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppres
Externí odkaz:
https://doaj.org/article/a35e725f4a31444ab59fa8714d1e455f
Autor:
Mohit Kumar Jolly, Marcelo Boareto, Bisrat G. Debeb, Nicola Aceto, Mary C. Farach-Carson, Wendy A. Woodward, Herbert Levine
Publikováno v:
npj Breast Cancer, Vol 3, Iss 1, Pp 1-8 (2017)
Abstract Metastases claim more than 90% of cancer-related patient deaths and are usually seeded by a subset of circulating tumor cells shed off from the primary tumor. In circulation, circulating tumor cells are found both as single cells and as clus
Externí odkaz:
https://doaj.org/article/911366c914c54315a28d13d968652f8a