Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.

Autor: Abdelsamie AS; ElexoPharm GmbH , Im Stadtwald, Building A1.2 , 66123 Saarbrücken , Germany.; Chemistry of Natural and Microbial Products Department , National Research Centre , Dokki, 12622 Cairo , Egypt., Herath S, Biskupek Y, Börger C; PharmBioTec GmbH , 66123 Saarbrücken , Germany., Siebenbürger L; PharmBioTec GmbH , 66123 Saarbrücken , Germany., Salah M; Department of Pharmaceutical and Medicinal Chemistry , Saarland University , 66123 Saarbrücken , Germany., Scheuer C, Marchais-Oberwinkler S; Institute of Pharmaceutical Chemistry , Philipps-University , 35032 Marburg , Germany., Frotscher M; Department of Pharmaceutical and Medicinal Chemistry , Saarland University , 66123 Saarbrücken , Germany., Pohlemann T, Menger MD, Hartmann RW; Department of Pharmaceutical and Medicinal Chemistry , Saarland University , 66123 Saarbrücken , Germany.; Department of Drug Design and Optimization , Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) , 66123 Saarbrücken , Germany., Laschke MW, van Koppen CJ; ElexoPharm GmbH , Im Stadtwald, Building A1.2 , 66123 Saarbrücken , Germany.; Department of Pharmaceutical and Medicinal Chemistry , Saarland University , 66123 Saarbrücken , Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Feb 14; Vol. 62 (3), pp. 1362-1372. Date of Electronic Publication: 2019 Jan 15.