Zobrazeno 1 - 10
of 338
pro vyhledávání: '"Bishr, Omary"'
Autor:
Jingyuan Sun, Pei Li, Honglian Gui, Laure Rittié, David B. Lombard, Katrin Rietscher, Thomas M. Magin, Qing Xie, Li Liu, M. Bishr Omary
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Keratin (K) and other intermediate filament (IF) protein mutations at conserved arginines disrupt keratin filaments into aggregates and cause human epidermolysis bullosa simplex (EBS; K14-R125C) or predispose to mouse liver injury (K18-R90C). The cha
Externí odkaz:
https://doaj.org/article/6e147275c606494284720d71e3764a41
Autor:
Zhiguo Zhang, Xiao Zhong, Hong Shen, Liang Sheng, Suthat Liangpunsakul, Anna S. Lok, M. Bishr Omary, Shaomeng Wang, Liangyou Rui
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Excessive expansion of cholangiocytes in the liver leads to ductular reaction and liver disease. Here, the authors show that genetic ablation, or pharmacological inhibition, of biliary NIK blocks ductular reaction, liver inflammation, and liver fibro
Externí odkaz:
https://doaj.org/article/7fee224b807148319c3090bb8e5f8b5c
Autor:
Juliana Bragazzi Cunha, Jared S. Elenbaas, Dhiman Maitra, Ning Kuo, Rodrigo Azuero-Dajud, Allison C. Ferguson, Megan S. Griffin, Stephen I. Lentz, Jordan A. Shavit, M. Bishr Omary
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Congenital erythropoietic porphyria (CEP) is a rare genetic disorder leading to accumulation of uro/coproporphyrin-I in tissues due to inhibition of uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe
Externí odkaz:
https://doaj.org/article/e06a443978e94eb7b7e1577a00409af2
Autor:
Karel P. Alcedo, Andres Guerrero, Venkatesha Basrur, Dong Fu, Monea L. Richardson, Joshua S. McLane, Chih‐Chiang Tsou, Alexey I. Nesvizhskii, Theodore H. Welling, Carlito B. Lebrilla, Carol A. Otey, Hong Jin Kim, M. Bishr Omary, Natasha T. Snider
Publikováno v:
Hepatology Communications, Vol 3, Iss 10, Pp 1400-1414 (2019)
CD73, a cell‐surface N‐linked glycoprotein that produces extracellular adenosine, is a novel target for cancer immunotherapy. Although anti‐CD73 antibodies have entered clinical development, CD73 has both protumor and antitumor functions, depen
Externí odkaz:
https://doaj.org/article/550bf2b9b1d9441695df8b5476ab00f0
Autor:
Dhiman Maitra, Juliana Bragazzi Cunha, Jared S. Elenbaas, Herbert L. Bonkovsky, Jordan A. Shavit, M. Bishr Omary
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 535-548 (2019)
Genetic porphyrias comprise eight diseases caused by defects in the heme biosynthetic pathway that lead to accumulation of heme precursors. Consequences of porphyria include photosensitivity, liver damage and increased risk of hepatocellular carcinom
Externí odkaz:
https://doaj.org/article/464f7792c73f4ad1aa5e832a15ccab59
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
Externí odkaz:
https://doaj.org/article/ba30a22ce1364886ab9fb2c0ed15d3d3
Autor:
Melis Sahinoz, Shafaq Khairi, Ashley Cuttitta, Graham F. Brady, Amit Rupani, Rasimcan Meral, Marwan K. Tayeh, Peedikayil Thomas, Meredith Riebschleger, Sandra Camelo-Piragua, Jeffrey W. Innis, M. Bishr Omary, Daniel E. Michele, Elif A. Oral
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 4, Iss 1, Pp 1-6 (2018)
Abstract Background Juvenile dermatomyositis (JDM) is an auto-immune muscle disease which presents with skin manifestations and muscle weakness. At least 10% of the patients with JDM present with acquired lipodystrophy. Laminopathies are caused by mu
Externí odkaz:
https://doaj.org/article/6ee72999fdbd46ada582876a50c577ad
Autor:
Raymond Kwan, Graham F. Brady, Maria Brzozowski, Sujith V. Weerasinghe, Hope Martin, Min-Jung Park, Makayla J. Brunt, Ram K. Menon, Xin Tong, Lei Yin, Colin L. Stewart, M. Bishr Omary
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 3, Pp 365-383 (2017)
Background & Aims: Lamins are nuclear intermediate filament proteins that comprise the major components of the nuclear lamina. Mutations in LMNA, which encodes lamins A/C, cause laminopathies, including lipodystrophy, cardiomyopathy, and premature
Externí odkaz:
https://doaj.org/article/6460db21f5444d62a8af8a332bfa76d6
Autor:
Dhiman Maitra, Eric L. Carter, Rani Richardson, Laure Rittié, Venkatesha Basrur, Haoming Zhang, Alexey I. Nesvizhskii, Yoichi Osawa, Matthew W. Wolf, Stephen W. Ragsdale, Nicolai Lehnert, Harald Herrmann, M. Bishr Omary
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 659-682.e1 (2019)
Background & Aims: Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma
Externí odkaz:
https://doaj.org/article/10bdb280b0dd465a91c8c70783932dcc
Autor:
Timothy C. Wang, M. Bishr Omary
Publikováno v:
Gastroenterology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa1dc2d3df0e642b0793f60a8ab0c8c0
https://doi.org/10.1053/j.gastro.2023.04.019
https://doi.org/10.1053/j.gastro.2023.04.019