Comparative Evaluation of Gemcabene and Peroxisome Proliferator–Activated Receptor Ligands in Transcriptional Assays of Peroxisome Proliferator–Activated Receptors

Autor: Bisgaier Cl, Srivastava Rak, Oniciu Dc

Publikováno v: Journal of Cardiovascular Pharmacology

Gemcabene, a late-stage clinical candidate, has shown efficacy for LDL-C, non-HDL cholesterol, apoB, triglycerides, and hsCRP reduction, all risk factors for cardiovascular disease. In rodents, gemcabene showed changes in targets, including apoC-III,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bcfaa4f74b129c7d45c0a29a28b24a
https://doi.org/10.1097/fjc.0000000000000580

Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH.

Autor: Oniciu DC; Gemphire Therapeutics Inc., Livonia, MI, United States of America., Hashiguchi T; SMC Laboratories, Inc., 2-16-1 Minami-Kamata Ota-City, Tokyo, Japan., Shibazaki Y; SMC Laboratories, Inc., 2-16-1 Minami-Kamata Ota-City, Tokyo, Japan., Bisgaier CL; Gemphire Therapeutics Inc., Livonia, MI, United States of America.

Publikováno v: PloS one [PLoS One] 2018 May 30; Vol. 13 (5), pp. e0194568. Date of Electronic Publication: 2018 May 30 (Print Publication: 2018).

Relation between carotid intima-media thickness, serum paraoxonase levels and severity of obstructive sleep apnea syndrome.

Autor: AKKURT, Esma Sevil¹ esma.sevil@hotmail.com, SAVAS BOZBAS, Serife², EROGLU, Serpil³, OZCALIK, Emre³, OZTURAN OZER, Eda⁴, AKINCI OZYUREK, Berna¹, ONER EYUBOGLU, Fusun²

Publikováno v: Bratislava Medical Journal / Bratislavské Lekárske Listy. 2023, Vol. 124 Issue 12, p886-891. 6p.

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