Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

Autor: Burn, J., Gerdes, A.M., Macrae, F., Mecklin, J.P., Moeslein, G., Olschwang, S., Eccles, D., Evans, D.G., Maher, E.R., Bertario, L., Bisgaard, M.L., Dunlop, M.G., Ho, J.W.C., Hodgson, S.V., Lindblom, A., Lubinski, J., Morrison, P.J., Murday, V., Ramesar, R., Side, L., Scott, R.J., Thomas, H.J.W., Vasen, H.F., Barker, G., Crawford, G., Elliott, F., Movahedi, M., Pylvanainen, K., Wijnen, J.T., Fodde, R., Lynch, H.T., Mathers, J.C., Bishop, D.T., CAPP2 Investigators

Publikováno v: Lancet (UK), 378(9809), 2081-2087. Elsevier Ltd.
Lancet, 378(9809), 2081-2087
Lancet
Burn, J, Gerdes, A-M, Macrae, F, Mecklin, J-P, Moeslein, G, Olschwang, S, Eccles, D, Evans, D G, Maher, E R, Bertario, L, Bisgaard, M-L, Dunlop, M G, Ho, J W C, Hodgson, S V, Lindblom, A, Lubinski, J, Morrison, P J, Murday, V, Ramesar, R, Side, L, Scott, R J, Thomas, H J W, Vasen, H F, Barker, G, Crawford, G, Elliott, F, Movahedi, M, Pylvanainen, K, Wijnen, J T, Fodde, R, Lynch, H T & Mathers, J C & Bishop, D T 2011, ' Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer : an analysis from the CAPP2 randomised controlled trial ', The Lancet, vol. 378, no. 9809, pp. 2081-7 . https://doi.org/10.1016/S0140-6736(11)61049-0

BACKGROUND: Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed prevention of colorectal cancer as a primary endpoint. The CAPP2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc677a4a6000a0a30c9712ddbe3acd9
https://doi.org/10.1016/s0140-6736(11)61049-0

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or 'multiple' colorectal adenomas.

Autor: Sieber, O.M., Lamlum, H., Crabtree, M. D., Rowan, A.J., Barclay, E., Lipton, L., Hodgson, S., Thomas, H.J.W., Neale, K., Phillips, R.K.S., Farrington, S>M., Dunlop, M.G., Mueller, H.J., Bisgaard, M.L., Bulow, S., Fidalgo, P., Albuquerque, C., Scarano, M.I., Bodmer, W.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 3/5/2002, Vol. 99 Issue 5, p2954, 6p, 3 Charts, 1 Graph

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