Lipids as Targets for Renal Cell Carcinoma Therapy

Autor: Bisera Stepanovska Tanturovska, Roxana Manaila, Doriano Fabbro, Andrea Huwiler

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 4, p 3272 (2023)

Kidney cancer is among the top ten most common cancers to date. Within the kidney, renal cell carcinoma (RCC) is the most common solid lesion occurring. While various risk factors are suspected, including unhealthy lifestyle, age, and ethnicity, gene

Externí odkaz: https://doaj.org/article/c34404ab52b840649f29fb3bfc688139

Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells

Autor: Redona Hafizi, Faik Imeri, Bisera Stepanovska Tanturovska, Roxana Manaila, Stephanie Schwalm, Sandra Trautmann, Roland H. Wenger, Josef Pfeilschifter, Andrea Huwiler

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 11, p 5882 (2022)

Erythropoietin (Epo) is a crucial hormone regulating red blood cell number and consequently the hematocrit. Epo is mainly produced in the kidney by interstitial fibroblast-like cells. Previously, we have shown that in cultures of the immortalized mou

Externí odkaz: https://doaj.org/article/528687afe5904c1f929dcfd5c280d696

Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice

Autor: Stephanie Schwalm, Andrea Huwiler, Liliana Schaefer, Josef Pfeilschifter, Bisera Stepanovska Tanturovska, Sarbari Saha, Faik Imeri, Herrmann Pavenstädt, Jinyang Zeng-Brouwers

Publikováno v: Imeri, Faik; Stepanovska Tanturovska, Bisera; Schwalm, Stephanie; Saha, Sarbari; Zeng-Brouwers, Jinyang; Pavenstädt, Herrmann; Pfeilschifter, Josef; Schaefer, Liliana; Huwiler, Andrea (2021). Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. Matrix biology, 98, pp. 32-48. Elsevier 10.1016/j.matbio.2021.05.003

The sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that is now appreciated as key regulatory factor for various cellular functions in the kidney, including matrix remodeling. It is generated by two sphingosine kinases (Sphk), Sphk1 and Sph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92693c53198bf13ba61f91647498d73f
https://doi.org/10.1016/j.matbio.2021.05.003

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo

Autor: Thomas Homann, Aleksandra Zivkovic, Andrea Huwiler, Bisera Stepanovska Tanturovska, Faik Imeri, Holger Stark, Burkhard Kleuser

Publikováno v: Molecules
Volume 26
Issue 17
Stepanovska Tanturovska, Bisera; Zivkovic, Aleksandra; Imeri, Faik; Homann, Thomas; Kleuser, Burkhard; Stark, Holger; Huwiler, Andrea (2021). ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules, 26(17) Molecular Diversity Preservation International MDPI 10.3390/molecules26175134
Molecules, Vol 26, Iss 5134, p 5134 (2021)

Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors. The cycle of S1P1 internalization upon S1P binding a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5eb3ae48ce46de4aa0f2be9b0736ad

Novel compounds with dual S1P receptor agonist and histamine H

Autor: Faik, Imeri, Bisera, Stepanovska Tanturovska, Aleksandra, Zivkovic, Gaby, Enzmann, Stephanie, Schwalm, Josef, Pfeilschifter, Thomas, Homann, Burkhard, Kleuser, Britta, Engelhardt, Holger, Stark, Andrea, Huwiler

Publikováno v: Neuropharmacology. 186

The sphingosine 1-phosphate (S1P) receptor 1 (S1P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de69538ae6361f0d493c6a95e7670a7d
https://pubmed.ncbi.nlm.nih.gov/33460688