Lipids as Targets for Renal Cell Carcinoma Therapy

Autor: Bisera Stepanovska Tanturovska, Roxana Manaila, Doriano Fabbro, Andrea Huwiler

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 4, p 3272 (2023)

Kidney cancer is among the top ten most common cancers to date. Within the kidney, renal cell carcinoma (RCC) is the most common solid lesion occurring. While various risk factors are suspected, including unhealthy lifestyle, age, and ethnicity, gene

Externí odkaz: https://doaj.org/article/c34404ab52b840649f29fb3bfc688139

Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells

Autor: Redona Hafizi, Faik Imeri, Bisera Stepanovska Tanturovska, Roxana Manaila, Stephanie Schwalm, Sandra Trautmann, Roland H. Wenger, Josef Pfeilschifter, Andrea Huwiler

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 11, p 5882 (2022)

Erythropoietin (Epo) is a crucial hormone regulating red blood cell number and consequently the hematocrit. Epo is mainly produced in the kidney by interstitial fibroblast-like cells. Previously, we have shown that in cultures of the immortalized mou

Externí odkaz: https://doaj.org/article/528687afe5904c1f929dcfd5c280d696

Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis

Autor: Bisera Stepanovska, Aleksandra Zivkovic, Gaby Enzmann, Silvia Tietz, Thomas Homann, Burkhard Kleuser, Britta Engelhardt, Holger Stark, Andrea Huwiler

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 18, p 6463 (2020)

Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune disease of the central nervous system (CNS) which is associated with lower life expectancy and disability. The experimental antigen-induced encephalomyelitis (EAE) in mice is a useful ani

Externí odkaz: https://doaj.org/article/1141dbef78104d2aaf572da56c169b77

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

Autor: Olivier Blanchard, Bisera Stepanovska, Manuel Starck, Martin Erhardt, Isolde Römer, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 5, p 1498 (2018)

Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate (S1P), which acts as a key regulator of inflammatory and fibrotic reactions, mainly via S1P receptor activation. Here, we show that in the human renal proximal tubular epithel

Externí odkaz: https://doaj.org/article/3006f2a5b62e46d497825225e500eff2

Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice

Autor: Stephanie Schwalm, Andrea Huwiler, Liliana Schaefer, Josef Pfeilschifter, Bisera Stepanovska Tanturovska, Sarbari Saha, Faik Imeri, Herrmann Pavenstädt, Jinyang Zeng-Brouwers

Publikováno v: Imeri, Faik; Stepanovska Tanturovska, Bisera; Schwalm, Stephanie; Saha, Sarbari; Zeng-Brouwers, Jinyang; Pavenstädt, Herrmann; Pfeilschifter, Josef; Schaefer, Liliana; Huwiler, Andrea (2021). Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. Matrix biology, 98, pp. 32-48. Elsevier 10.1016/j.matbio.2021.05.003

The sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that is now appreciated as key regulatory factor for various cellular functions in the kidney, including matrix remodeling. It is generated by two sphingosine kinases (Sphk), Sphk1 and Sph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92693c53198bf13ba61f91647498d73f
https://doi.org/10.1016/j.matbio.2021.05.003