A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹⁸F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.

Autor: Matusiak N; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands., Castelli R; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands., Tuin AW; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands., Overkleeft HS; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands., Wisastra R; Department of Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands., Dekker FJ; Department of Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands., Prély LM; Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands., Bischoff R, van Waarde A; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands., Dierckx RA; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands., Elsinga PH; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. Electronic address: p.h.elsinga@umcg.nl.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 Jan 01; Vol. 23 (1), pp. 192-202. Date of Electronic Publication: 2014 Nov 15.