MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ.

Autor: Schrenk S; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Bischoff LJ; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Goines J; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Cai Y; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Vemaraju S; Science of Light Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Odaka Y; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Biology, University of Cincinnati Blue Ash College, Blue Ash, OH, USA., Good SR; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Palumbo JS; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Szabo S; Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Reynaud D; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Van Raamsdonk CD; Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada., Lang RA; Science of Light Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Boscolo E; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. elisa.boscolo@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. elisa.boscolo@cchmc.org.

Publikováno v: Nature communications [Nat Commun] 2023 Apr 06; Vol. 14 (1), pp. 1929. Date of Electronic Publication: 2023 Apr 06.