1-(2-Chlorophenyl)-6,7-dimethoxy-3-methyl-3,4-dihydroisoquinoline

Autor: Miglena Milusheva, Vera Gledacheva, Iliyana Stefanova, Stoyanka Nikolova

Publikováno v: Molbank, Vol 2023, Iss 2, p M1608 (2023)

This article concerns the synthesis and in silico evaluation of 1-(2-chlorophenyl)-6-7-dimethoxy-3-methyl-3,4-dihydrogioquinoline (DIQ). A variety of in silico simulations were applied to assess the potential biological activity and toxicity of the c

Externí odkaz: https://doaj.org/article/5b83436024de4e2d843276774622e11d

Synthesis of the Multidrug Reversal Agent Ko143 and Its Parent Natural Product Fumitremorgin C

Autor: Zechner, Melanie, Altmann, Karl-Heinz

Publikováno v: Helvetica Chimica Acta, 106 (2)

Ko143 is a tetracyclic, synthetic analog of the fungal metabolite fumitremorgin C. Ko143 is a potent and specific inhibitor of the membrane-bound efflux transporter ABCG2, and it reverses ABCG2-mediated drug resistance in cancer cells. Here, we descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a5ff91d287355f8ae9f150ade581ca
https://hdl.handle.net/20.500.11850/599316

Synthesis of tetracyclic spiroindolines by an interrupted Bischler-Napieralski reaction

Autor: Eelco Ruijter, Matteo Faltracco

Publikováno v: Organic & Biomolecular Chemistry
Organic and Biomolecular Chemistry, 19(44), 9641-9644. Royal Society of Chemistry
Faltracco, M & Ruijter, E 2021, ' Synthesis of tetracyclic spiroindolines by an interrupted Bischler-Napieralski reaction : total synthesis of akuammicine ', Organic and Biomolecular Chemistry, vol. 19, no. 44, pp. 9641-9644 . https://doi.org/10.1039/d1ob01966j

Judicious substrate design allows interruption of the classical Bischler–Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94177aa298f831abfccb87eda5338b0
https://doi.org/10.1039/d1ob01966j

Synthesis and X-ray crystallographic analysis of free base and hexafluorophosphate salts of 3,4-dihydroisoquinolines from the Bischler–Napieralski reaction

Autor: Cristian C. Granados, Carlos E. Puerto Galvis, Vladimir V. Kouznetsov, Mario A. Macías

Publikováno v: New Journal of Chemistry. 45:1565-1572

The Bischler–Napieralski reaction of N-phenylethyl cinnamamides was investigated in acetonitrile and 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim]PF6). Strong effects on the nature of the isolated products were observed depending on the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0c2ebdf75413f7678b2a32baa5bed85
https://doi.org/10.1039/d0nj05235c

Collective Total Synthesis of Aspidofractinine Alkaloids through the Development of a Bischler–Napieralski/Semipinacol Rearrangement Reaction

Autor: Xiao-Ming Zhang, Tian Ke, Fu-Min Zhang, Qing-Bo Zhuang, Yong-Qiang Tu, Xiang Guo, Rui-Qi Si, Shuang-Hu Wang

Publikováno v: Angewandte Chemie International Edition. 59:21954-21958

A tandem Bischler-Napieralski/semipinacol rearrangement reaction has been developed for the purpose of assembling a bis(spirocyclic) indole framework, a privileged structural unit of aspidofractinine-type monoterpenoid indole alkaloids, and was used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec810bdc124869f7b7d54ed068d388d1
https://doi.org/10.1002/anie.202009238