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Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses

Autor: Jerzy Samolej, Diogo Correa Mendonca, Nicole Upfold, Marion McElwee, Mariann Landsberger, Artur Yakimovich, Arvind H. Patel, Blair L. Strang, Jason Mercer

Publikováno v: Microbiology Spectrum, Vol 12, Iss 4 (2024)

ABSTRACTWe previously identified the bisbenzimide Hoechst 33342 (H42) as a potent multi-stage inhibitor of the prototypic poxvirus, the vaccinia virus (VACV), and several parapoxviruses. A recent report showed that novel bisbenzimide compounds simila

Externí odkaz: https://doaj.org/article/a63ca18ee1a7422e8517c64104035fc0

Characterization of the Minor Groove Environment in a Drug-DNA Complex: Bisbenzimide Bound to the poly[d(AT)]· poly[d(AT)]duplex

Autor: Jin, Renzhe, Breslauer, Kenneth J.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1988 Dec 01. 85(23), 8939-8942.

Externí odkaz: https://www.jstor.org/stable/32861

Inhibition of Poxvirus Gene Expression and Genome Replication by Bisbenzimide Derivatives.

Autor: Yakimovich, Artur^1,2, Huttunen, Moona², Zehnder, Benno³, Coulter, Lesley J.⁴, Gould, Victoria², Schneider, Christoph⁵, Kopf, Manfred⁵, McInnes, Colin J.⁴, Greber, Urs F.¹ urs.greber@imls.uzh.ch, Mercer, Jason^2,3 jason.mercer@ucl.ac.uk

Publikováno v: Journal of Virology. 9/15/2017, Vol. 91 Issue 18, p1-15. 15p.

Identification and characterization of bisbenzimide compounds that inhibit human cytomegalovirus replication.

Autor: Falci Finardi N; Institute of Infection & Immunity, St George's, University of London, London, UK., Kim H; Department of Physics and Astronomy, University of Texas Rio Grande Valley, Edinburg, TX, USA.; Biochemistry and Molecular Biology Program, University of Texas Rio Grande Valley, Edinburg, TX, USA., Hernandez LZ; Department of Physics and Astronomy, University of Texas Rio Grande Valley, Edinburg, TX, USA.; Biochemistry and Molecular Biology Program, University of Texas Rio Grande Valley, Edinburg, TX, USA.; Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, Troy, NY, USA., Russell MRG; The Francis Crick Institute, London, UK., Ho CM; Institute of Infection & Immunity, St George's, University of London, London, UK., Sreenu VB; MRC - University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, UK., Wenham HA; Institute of Infection & Immunity, St George's, University of London, London, UK., Merritt A; Centre for Therapeutic Discovery, LifeArc, Stevenage, UK., Strang BL; Institute of Infection & Immunity, St George's, University of London, London, UK.; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

Publikováno v: The Journal of general virology [J Gen Virol] 2021 Dec; Vol. 102 (12).