Analysis of the efficacy of bis(methyl)gliotoxin for early invasive aspergillosis detection and to guide antifungal treatment in neutropenic pediatric oncology patients

Autor: Domingo, María Pilar, Nabal, Sandra, Redrado, Sergio, López Gómez, Concepción, Rodríguez-Vigil, C., Muñoz Mellado, A., Calvo, Carlota, Rezusta, Antonio, Pardo, Julián, Gálvez Buerba, Eva Mª

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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of the poster presented at the 9th Trends in Medical Mycology (TIMM 2019), 11-14 October 2019, Nice (France).-- P152.
[Objectives]: Invasive pulmonary aspergillosis (IPA) is a leading cause of morbidity and mortality in immunocompromised patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5d8ba84aa5b9caa7f087f09101eea143
http://hdl.handle.net/10261/255255

DETECTION OF GLIOTOXIN BUT NOT BIS(METHYL)GLIOTOXIN IN PLASMA FROM BIRDS WITH CONFIRMED AND PROBABLE ASPERGILLOSIS

Autor: Lisa, Reidy, Guillaume, Desoubeaux, Julia, Cardenas, Joshua, Seither, Kristin, Kahl, David, Chauvin, Michael, Adkesson, Pamela, Govett, Copper, Aitken-Palmer, Cynthia, Stadler, Maryanne, Tocidlowski, Gayle, Sirpenski, Ellen, Bronson, Carolyn, Cray

Publikováno v: Journal of Zoo and Wildlife Medicine. 53

Aspergillosis remains a difficult disease to diagnose antemortem in many species, especially avian species. In the present study, banked plasma samples from various avian species were examined for gliotoxin (GT), which is a recognized key virulence f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a662c681606491c07c191f0aa439fb24
https://doi.org/10.1638/2021-0070

Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis

Autor: Jacques F. Meis, Antonio Rezusta, Eva M. Galvez, Arno Müllbacher, Pilar Delgado, María Pilar Domingo, Lourdes Roc, Cristina Colmenarejo, Carmen Jarne, Julián Pardo, María José Revillo, Luis Martínez-Lostao

Publikováno v: Diagnostic Microbiology and Infectious Diseases, 73, 1, pp. 57-64
Digital.CSIC. Repositorio Institucional del CSIC
instname
Diagnostic Microbiology and Infectious Diseases, 73, 57-64

The virulence factor gliotoxin (GT) and its inactive derivative, bis(methylthio)gliotoxin (bmGT), are produced by pathogens of the genus Aspergillus. Here we report the detection of GT and bmGT in serum of humans at risk of invasive aspergillosis (IA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a70e368786d20e8340987077074838
https://hdl.handle.net/2066/124251

Prospective evaluation of a combination of fungal biomarkers for the diagnosis of invasive fungal disease in high‐risk haematology patients.

Autor: Hammarström, Helena^1,2 helena.hammarstrom@infect.gu.se, Stjärne Aspelund, Anna³, Christensson, Bertil³, Heußel, Claus Peter^4,5,6, Isaksson, Jenny², Kondori, Nahid^1,2, Larsson, Lennart⁷, Markowicz, Pawel⁷, Richter, Johan⁸, Wennerås, Christine^1,2, Friman, Vanda¹

Publikováno v: Mycoses. Sep2018, Vol. 61 Issue 9, p623-632. 10p.

Integration of In Silico and In Vitro Analysis of Gliotoxin Production Reveals a Narrow Range of Producing Fungal Species.

Autor: Redrado, Sergio¹ (AUTHOR) sergio-redrado@hotmail.com, Esteban, Patricia² (AUTHOR) patri.estb@gmail.com, Domingo, María Pilar¹ (AUTHOR) mpdomingo@icb.csic.es, Lopez, Concepción³ (AUTHOR) concepta963@gmail.com, Rezusta, Antonio³ (AUTHOR) arezusta@unizar.es, Ramirez-Labrada, Ariel² (AUTHOR) aramirezlabrada@yahoo.es, Arias, Maykel² (AUTHOR) maykelariascabrero@gmail.com, Pardo, Julián^2,4,5 (AUTHOR) pardojim@unizar.es, Galvez, Eva M.¹ (AUTHOR) eva@icb.csic.es

Publikováno v: Journal of Fungi. Apr2022, Vol. 8 Issue 4, p361-361. 19p.