Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Biruk, Kassa"'
Autor:
Biruk Kassa, Dara C. Fonseca‐Balladares, Rahul Kumar, Michael H. Lee, Claudia Mickael, Linda Sanders, Kevin Nolan, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Whether all Schistosoma species cause pulmonary hypertension (PH) is unclear. Experimentally exposing mice to Schistosoma haematobium eggs caused PH, which was less severe than that induced by S. mansoni exposure. These findings align with t
Externí odkaz:
https://doaj.org/article/46ef8c2b319c48a4b72d155414d53fe3
Autor:
Sue Gu, Claudia Mickael, Rahul Kumar, Michael H. Lee, Linda Sanders, Biruk Kassa, Julie Harral, Jason Williams, Kirk C. Hansen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Right ventricular (RV) failure is the primary cause of death in pulmonary hypertension (PH), but the mechanisms of RV failure are not well understood. We hypothesized macrophages in the RV contribute to the RV response in PH. We induced PH i
Externí odkaz:
https://doaj.org/article/783929df348a4cba9dd4c63c25ba23b0
Autor:
Edford Sinkala, Hanan Yusuf Ahmed, Jean Pierre Sibomana, Michael H. Lee, Biruk Kassa, Rahul Kumar, Sula Mazimba, Amsalu B. Binegdie, Sydney Mpisa, Kawana Wamundila, Brian B. Graham, Joan F. Hilton
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 2, Pp n/a-n/a (2022)
Abstract Schistosomiasis is a major cause of pulmonary arterial hypertension (PAH) worldwide, but the prevalence and risk factors for schistosomiasis‐associated PAH (SchPAH) development are not well understood. Schistosomiasis‐associated hepatosp
Externí odkaz:
https://doaj.org/article/13a2bfdef47c4bb5adde14a1d0354d8e
Autor:
Biruk Kassa, Michael H Lee, Rahul Kumar, Claudia Mickael, Linda Sanders, Rubin M Tuder, Margaret Mentink-Kane, Brian B Graham
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010343 (2022)
BackgroundSchistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-d
Externí odkaz:
https://doaj.org/article/598c70bd548d40a9ac150d51cce361c6
Autor:
Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B Graham
Publikováno v:
Clinical Science. 137:617-631
Background: Pulmonary hypertension (PH) can occur as a complication of schistosomiasis. In humans, schistosomiasis-PH persists despite antihelminthic therapy and parasite eradication. We hypothesized that persistent disease arises as a consequence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0db8c3832680d074ad96e77b3fa89f
https://doi.org/10.1042/cs20220642
https://doi.org/10.1042/cs20220642
Autor:
Jean Pierre Sibomana, Aloma Campeche, Roberto J. Carvalho-Filho, Ricardo Amorim Correa, Helena Duani, Virginia Pacheco Guimaraes, Joan F. Hilton, Biruk Kassa, Rahul Kumar, Michael H. Lee, Camila M. C. Loureiro, Sula Mazimba, Claudia Mickael, Rudolf K. F. Oliveira, Jaquelina S. Ota-Arakaki, Camila Farnese Rezende, Luciana C. S. Silva, Edford Sinkala, Hanan Yusuf Ahmed, Brian B. Graham
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic schistosomiasis, particularly due to S. mansoni. The lung bloo
Externí odkaz:
https://doaj.org/article/305f8bf524b54848967de4207fdbe852
Autor:
Rahul Kumar, Michael H. Lee, Claudia Mickael, Biruk Kassa, Qadar Pasha, Rubin Tuder, Brian Graham
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) gains entry into the lung epithelial cells by binding to the surface protein angiotensin-converting enzyme 2. Severe SARS-CoV-2 infection, also known as coronavirus disease 2019 (COVID-19),
Externí odkaz:
https://doaj.org/article/75054e8c4b604736bc42c19e7ce892ee
Autor:
Rahul Kumar, Claudia Mickael, Biruk Kassa, Liya Gebreab, Jeffrey C. Robinson, Daniel E. Koyanagi, Linda Sanders, Lea Barthel, Christina Meadows, Daniel Fox, David Irwin, Min Li, B. Alexandre McKeon, Suzette Riddle, R. Dale Brown, Leslie E. Morgan, Christopher M. Evans, Daniel Hernandez-Saavedra, Angela Bandeira, James P. Maloney, Todd M. Bull, William J. Janssen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that int
Externí odkaz:
https://doaj.org/article/12cae9f76300462c9772bdd1e67bd44a
Autor:
Kewal Asosingh, Nicholas Wanner, Kelly Weiss, Kimberly Queisser, Liya Gebreab, Biruk Kassa, Eric Stuehr, Brian Graham, Serpil Erzurum
Publikováno v:
Blood Advances, Vol 1, Iss 9, Pp 526-534 (2017)
Abstract: Accumulating evidence shows a causative role for the bone marrow (BM) in the genesis and progression of pulmonary hypertension (PH). Engraftment of BM hematopoietic stem cells from PH patients to mice reproduces the cardiopulmonary patholog
Externí odkaz:
https://doaj.org/article/4a4a4dc9eaeb48588de57f50d69db1df
Autor:
Michael H. Lee, Linda Sanders, Rahul Kumar, Daniel Hernandez-Saavedra, Xin Yun, Joshay A. Ford, Mario J. Perez, Claudia Mickael, Aneta Gandjeva, Daniel E. Koyanagi, Julie W. Harral, David C. Irwin, Biruk Kassa, Robert H. Eckel, Larissa A. Shimoda, Brian B. Graham, Rubin M. Tuder
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L355-L371
Dysregulated metabolism characterizes both animal and human forms of pulmonary hypertension (PH). Enzymes involved in fatty acid metabolism have previously not been assessed in human pulmonary arteries affected by pulmonary arterial hypertension (PAH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a550f31d7f6c9791f9e7f174c7f264f
https://doi.org/10.1152/ajplung.00039.2022
https://doi.org/10.1152/ajplung.00039.2022