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Autor:
Monica Venner, Dieter Rosskopf, Heyo K. Kroemer, Nina Höhensteiger, Alexa Bornhorst, Ulrike Adam, Markus Grube, Werner Weitschies, Birthe Schock, W. Siegmund, Jette Peters, Eberhard Scheuch
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 381:161-169
Macrolide antibiotics penetrate in the lung against steep concentration gradients into the epithelial lining fluid (ELF) and broncho-alveolar cells (BAC). Since they interact with ABCB1, ABCC2, and organic anion transporting proteins (OATPs), which a