Excitatory amino acid neurotoxicity and modulation of glutamate receptor expression in organotypic brain slice cultures

Autor: Bjarne Winther Kristensen, Birthe Jakobsen, Jens Zimmer, Jens Noraberg

Publikováno v: Zimmer, J, Kristensen, B W, Jakobsen, B & Noraberg, J 2000, ' Excitatory amino acid neurotoxicity and modulation of glutamate receptor expression in organotypic brain slice cultures ', Amino Acids, vol. 19, no. 1, pp. 7-21 . https://doi.org/10.1007/s007260070029

Using organotypic slice cultures of hippocampus and cortex-striatum from newborn to 7 day old rats, we are currently studying the excitotoxic effects of kainic acid (KA), AMPA and NMDA and the neuroprotective effects of glutamate receptor blockers, l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab95f56bbde77223408edd0ed76ddefa
https://doi.org/10.1007/s007260070029

Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures

Autor: João O. Malva, Birthe Jakobsen, Ana P. Silva, Jens Zimmer, Caetana M. Carvalho, Arsélio P. Carvalho, Paulo S. Pinheiro

Publikováno v: CIÊNCIAVITAE
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Glutamate and NPY have been implicated in hippocampal neuropathology in temporal lobe epilepsy. Thus, we investigated the involvement of NPY receptors in mediating neuroprotection against excitotoxic insults in organotypic cultures of rat hippocampal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4392d127d2916b4bbceff006ceb9a1b9
https://doi.org/10.1096/fj.02-0885fje

Characterization of organotypic ventral mesencephalic cultures from embryonic mice and protection against MPP toxicity by GDNF

Autor: C Rosenblad, Jan B. Gramsbergen, Birthe Jakobsen, A Møller Dall, Jens Zimmer

Publikováno v: Jakobsen, B, Gramsbergen, J B, Møller Dall, A, Rosenblad, C & Zimmer, J 2005, ' Characterization of organotypic ventral mesencephalic cultures from embryonic mice and protection against MPP toxicity by GDNF ', European Journal of Neuroscience, vol. 21, no. 11, pp. 2939-48 . https://doi.org/10.1111/j.1460-9568.2005.04138.x

Udgivelsesdato: 2005-Jun We characterized organotypic ventral mesencephalic (VM) cultures derived from embryonic day 12 (E12) mice (CBL57/bL6) in terms of number of dopaminergic neurons, cell soma size and dopamine production in relation to time in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac2efbd1ff9eb555d2e5c1d09a07207
https://pubmed.ncbi.nlm.nih.gov/15978005

Chronic exposure of kainate and NBQX changes AMPA toxicity in hippocampal slice cultures

Autor: Jens Zimmer, Birthe Jakobsen

Publikováno v: Jakobsen, B & Zimmer J. 2001, ' Chronic exposure of kainate and NBQX changes AMPA toxicity in hippocampal slice cultures ', NeuroReport, vol. 12, pp. 3593-3597 . https://doi.org/10.1097/00001756-200111160-00044

Receptor agonist/antagonist mediated modulation of the excitotoxic effect of AMPA was studied in organotypic hippocampal slice cultures. Treatment of developing cultures for 2 weeks with a subtoxic dose of 2 microM kainate reduced the toxicity of 3 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95dc4aac90af98e1459db7d64bd2366b
https://portal.findresearcher.sdu.dk/da/publications/9c5cae20-6fcd-11db-81a9-000ea68e967b

Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures

Autor: Sara Xapelli, Liliana Bernardino, Jens Zimmer, Ana P. Silva, João O. Malva, Frantz Rom Poulsen, Annamaria Vezzani, Catarina R. Oliveira, Birthe Jakobsen

Publikováno v: CIÊNCIAVITAE
Bernardino, L, Xapelli, S, Silva, A P, Jakobsen, B, Poulsen, F R, Oliveira, C R, Vezzani, A, Malva, J O & Zimmer, J 2005, ' Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. ', Journal of Neuroscience, vol. 25, no. 29, pp. 6734-44 . https://doi.org/10.1523/JNEUROSCI.1510-05.2005
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Udgivelsesdato: 2005-Jul-20 The inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha (TNF-alpha) have been identified as mediators of several forms of neurodegeneration in the brain. However, they can produce either deleterious or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383c813c7858d6c008677d15599c87df
http://hdl.handle.net/10316/12624