Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Birthe Gericke"'
Autor:
Thuy Thi Lai, Birthe Gericke, Malte Feja, Michael Conoscenti, Moriel Zelikowsky, Franziska Richter
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Synucleinopathies are neurodegenerative disorders characterized by alpha-synuclein (αSyn) accumulation in neurons or glial cells, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). αSy
Externí odkaz:
https://doaj.org/article/b7cb7ef4a61c4452abb309060daa8aef
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106298- (2023)
Dysfunction of the blood-brain barrier (BBB) is suggested to play a critical role in the pathological mechanisms of Parkinson's disease (PD). PD-related pathology such as alpha-synuclein accumulation and inflammatory processes potentially affect the
Externí odkaz:
https://doaj.org/article/217dcfb9dab846bf9240c64a11f7abef
Autor:
Birthe Gericke, Saskia Borsdorf, Inka Wienböker, Andreas Noack, Sandra Noack, Wolfgang Löscher
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-22 (2021)
Abstract Background In vitro models based on brain capillary endothelial cells (BCECs) are among the most versatile tools in blood–brain barrier research for testing drug penetration into the brain and how this is affected by efflux transporters su
Externí odkaz:
https://doaj.org/article/f52efc29c05a45a5a849e5b83cf4f958
Autor:
Ronja Storjohann, Birthe Gericke, Janin Reifenrath, Timo Herrmann, Peter Behrens, Hilke Oltmanns, Jessica Meißner
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2565 (2023)
A major drawback of nanoparticles (NPs) for biomedical applications is their preferential phagocytosis in immune cells, which can be avoided by surface modifications like PEGylation. Nevertheless, examinations of different polyethylene glycol (PEG) c
Externí odkaz:
https://doaj.org/article/559ba2094d3f4ca0a833a7ce33eb642d
Autor:
Birthe Gericke, Kerstin Römermann, Andreas Noack, Sandra Noack, Jessica Kronenberg, Ingolf Ernst Blasig, Wolfgang Löscher
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Predictive in vitro models of the human blood–brain barrier (BBB) are essential in early drug discovery and development. Among available immortalized human brain capillary endothelial cell lines (BCECs), the hCMEC/D3 cell line h
Externí odkaz:
https://doaj.org/article/df1704e7aa844886b4e4a47ba6bef59f
Autor:
Philip Hampel, Marie Johne, Björn Gailus, Alexandra Vogel, Alina Schidlitzki, Birthe Gericke, Kathrin Töllner, Wiebke Theilmann, Christopher Käufer, Kerstin Römermann, Kai Kaila, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105297- (2021)
Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in the generation of seizures and epilepsy. However, conclusions from studies on the NKCC1-specific inhibitor, bumetanide, are equivocal, which is a consequence of
Externí odkaz:
https://doaj.org/article/2a709dc4887c4da59a0cb341c6f812df
Publikováno v:
Cells, Vol 11, Iss 9, p 1556 (2022)
The drug efflux transporter P-glycoprotein (Pgp; ABCB1) plays an important role in drug absorption, disposition, and elimination. There is an ongoing debate whether, in addition to its localization at the plasma membrane, Pgp may also be expressed at
Externí odkaz:
https://doaj.org/article/5658cf4e4ee74958b47c03c42d346cd2
Autor:
Alina Schidlitzki, Pablo Bascuñana, Prashant K. Srivastava, Lisa Welzel, Friederike Twele, Kathrin Töllner, Christopher Käufer, Birthe Gericke, Rahel Feleke, Martin Meier, Andras Polyak, Tobias L. Ross, Ingo Gerhauser, Jens P. Bankstahl, Michael R. Johnson, Marion Bankstahl, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis. For proof of concept we combined two drugs (levetiracetam and topiramate) for which in sili
Externí odkaz:
https://doaj.org/article/87f6ca923e384f6d9e939b1b144f625c
Autor:
Wolfgang Löscher, Birthe Gericke
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 966 (2020)
The blood-brain barrier (BBB) limits the pharmacotherapy of several brain disorders. In addition to the structural and metabolic characteristics of the BBB, the ATP-driven, drug efflux transporter P-glycoprotein (Pgp) is a selective gatekeeper of the
Externí odkaz:
https://doaj.org/article/53ce1698d9c243d1a6abbb4c64cb3467
Autor:
Sonja Schmidt, Birthe Gericke, Giulio Fracasso, Dunia Ramarli, Marco Colombatti, Hassan Y Naim
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66193 (2013)
Prostate-specific membrane antigen (PSMA) is a type-II membrane glycoprotein that was initially identified in LNCaP cells. It is expressed at elevated levels in prostate cancer. In view of the correlation between the expression levels of PSMA and dis
Externí odkaz:
https://doaj.org/article/67c469f490a94b939a5e6dc039dd9ca9