Comparison of Routes of Administration, Frequency, and Duration of Favipiravir Treatment in Mouse and Guinea Pig Models of Ebola Virus Disease

Autor: Dylan M. Johnson, Terry Juelich, Lihong Zhang, Jennifer K. Smith, Birte K. Kalveram, David Perez, Jeanon Smith, Michael R. Grimes, Tania Garron, Maricela Torres, Shane Massey, Trevor Brasel, David W. C. Beasley, Alex N. Freiberg, Jason E. Comer

Publikováno v: Viruses, Vol 16, Iss 7, p 1101 (2024)

Favipiravir is a ribonucleoside analogue that has been explored as a therapeutic for the treatment of Ebola Virus Disease (EVD). Promising data from rodent models has informed nonhuman primate trials, as well as evaluation in patients during the 2013

Externí odkaz: https://doaj.org/article/930a651013754a5698d362b0dbc18049

Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Autor: Zhiqiang Ku, Xuping Xie, Jianqing Lin, Peng Gao, Bin Wu, Abbas El Sahili, Hang Su, Yang Liu, Xiaohua Ye, Eddie Yongjun Tan, Xin Li, Xuejun Fan, Boon Chong Goh, Wei Xiong, Hannah Boyd, Antonio E. Muruato, Hui Deng, Hongjie Xia, Jing Zou, Birte K. Kalveram, Vineet D. Menachery, Ningyan Zhang, Julien Lescar, Pei-Yong Shi, Zhiqiang An

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Bispecific antibodies can have advantages compared to antibody cocktails. Here, the authors engineer and characterize two different approaches for generating bispecific SARS-CoV-2 specific antibodies and find that only one design increases antigen-bi

Externí odkaz: https://doaj.org/article/fd47417632fa4c60aed000fba0b0607c

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif

Autor: Yan Fang, Pengcheng Sun, Xuping Xie, Mingjian Du, Fenghe Du, Jianfeng Ye, Birte K. Kalveram, Jessica A. Plante, Kenneth S. Plante, Bo Li, Xiao-chen Bai, Pei-Yong Shi, Zhijian J. Chen

Publikováno v: Science Immunology. 7

The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as the Omicron variants that are highly transmissible and immune evasive, underscores the need to develop therapeutic antibodies with broad neutralizing activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7a2b9c210a8f8d65609c20fcb013b3
https://doi.org/10.1126/sciimmunol.abp9962

Comparison of Routes of Administration, Frequency, and Duration of Favipiravir Treatment in Mouse and Guinea Pig Models of Ebola Virus Disease.

Autor: Johnson, Dylan M.^1,2 (AUTHOR), Juelich, Terry³ (AUTHOR) tljuelic@utmb.edu, Zhang, Lihong³ (AUTHOR), Smith, Jennifer K.³ (AUTHOR), Kalveram, Birte K.³ (AUTHOR), Perez, David⁴ (AUTHOR), Smith, Jeanon⁵ (AUTHOR) chmassey@utmb.edu, Grimes, Michael R.⁶ (AUTHOR) mrgrimes@houston-methodist.org, Garron, Tania¹ (AUTHOR), Torres, Maricela¹ (AUTHOR), Massey, Shane⁵ (AUTHOR), Brasel, Trevor^1,5 (AUTHOR), Beasley, David W. C.^1,5 (AUTHOR), Freiberg, Alex N.³ (AUTHOR) anfreibe@utmb.edu, Comer, Jason E.^1,5 (AUTHOR) anfreibe@utmb.edu

Publikováno v: Viruses (1999-4915). Jul2024, Vol. 16 Issue 7, p1101. 12p.

Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts.

Autor: Warmbrod, K. Lane¹, Patterson, Edward I.¹, Kautz, Tiffany F.², Stanton, Adam³, Rockx-Brouwer, Dedeke¹, Kalveram, Birte K.¹, Khanipov, Kamil⁴, Thangamani, Saravanan¹, Fofanov, Yuriy⁴, Forrester, Naomi L.¹ n.forrester-soto@keele.ac.uk

Publikováno v: PLoS Pathogens. 4/4/2019, Vol. 15 Issue 4, p1-20. 20p.