Výsledky vyhledávání - "Birte, Vester"

Akademický článek

Amplification and Re-Generation of LNA-Modified Libraries

Autor: Jesper Wengel, Birte Vester, Lykke H. Hansen, Rakesh N. Veedu, Holger Doessing

Publikováno v: Molecules, Vol 17, Iss 11, Pp 13087-13097 (2012)

Locked nucleic acids (LNA) confer high thermal stability and nuclease resistance to oligonucleotides. The discovery of polymerases that accept LNA triphosphates has led us to propose a scheme for the amplification and re-generation of LNA-containing

Externí odkaz: https://doaj.org/article/4f7e0983969e4d2398bfc03a60d6f8f3

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Akademický článek

Locked and Unlocked Nucleosides in Functional Nucleic Acids

Autor: Birte Vester, Holger Doessing

Publikováno v: Molecules, Vol 16, Iss 6, Pp 4511-4526 (2011)

Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of mod

Externí odkaz: https://doaj.org/article/b457a738fe2f4def87bad70d08d04838

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Akademický článek

Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases.

Autor: Eleni Ntokou, Lykke Haastrup Hansen, Jacob Kongsted, Birte Vester

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145655 (2015)

Cfr and RlmN methyltransferases both modify adenine 2503 in 23S rRNA (Escherichia coli numbering). RlmN methylates position C2 of adenine while Cfr methylates position C8, and to a lesser extent C2, conferring antibiotic resistance to peptidyl transf

Externí odkaz: https://doaj.org/article/0b9486d6d041444189ac210603abd193

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Mapping of ribosomal 23S ribosomal RNA modifications inClostridium sporogenes

Autor: Birte Vester, Finn Kirpekar, Julie Mundus, Stine Tryggedsson, Eleni Ntokou, Patricia Teixeira Dos Santos, Lykke Haastrup Hansen

Publikováno v: Kirpekar, F, Hansen, L H, Mundus, J, Tryggedsson, S, Teixeira Dos Santos, P, Ntokou, E & Vester, B 2018, ' Mapping of ribosomal 23S ribosomal RNA modifications in Clostridium sporogenes ', RNA Biology, vol. 15, no. 8, pp. 1060–1070 . https://doi.org/10.1080/15476286.2018.1486662

All organisms contain RNA modifications in their ribosomal RNA (rRNA), but the importance, positions and exact function of these are still not fully elucidated. Various functions such as stabilizing structures, controlling ribosome assembly and facil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0a0892f344215a8bdab0fa6d961717
https://doi.org/10.1080/15476286.2018.1486662

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The cfr and cfr-like multiple resistance genes

Autor: Birte Vester

Publikováno v: Vester, B 2018, ' The cfr and cfr-like multiple resistance genes ', Research in Microbiology, vol. 169, no. 2, pp. 61-66 . https://doi.org/10.1016/j.resmic.2017.12.003

The Cfr methyl transferase causes an RNA methylation of the bacterial ribosomes impeding reduced or abolished binding of many antibiotics acting at the peptidyl transferase center. It provides multi-resistance to eight classes of antibiotics, most of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620e880fa8e4fa2b46f88a369abb9611
https://doi.org/10.1016/j.resmic.2017.12.003

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Oligonucleotides Containing Aminated 2′-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA

Autor: Niels Johan Christensen, Jesper Wengel, Birte Vester, Simone V Samuelsen, Chenguang Lou

Publikováno v: Lou, C, Samuelsen, S V, Christensen, N J, Vester, B & Wengel, J 2017, ' Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA ', Bioconjugate Chemistry, vol. 28, no. 4, pp. 1214-1220 . https://doi.org/10.1021/acs.bioconjchem.7b00061

Mono- and diaminated 2'-amino-LNA monomers were synthesized and introduced into oligonucleotides. Each modification imparts significant stabilization of nucleic acid duplexes and triplexes, excellent sequence selectivity, and significant nuclease res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd95f00e8f9326646fae2b55201b96bf
https://doi.org/10.1021/acs.bioconjchem.7b00061

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Antisense Oligonucleotides Internally Labeled with Peptides Show Improved Target Recognition and Stability to Enzymatic Degradation

Autor: Knud J. Jensen, Kira Astakhova, Lykke Haastrup Hansen, Birte Vester, Maria Taskova, Charlotte Madsen

Publikováno v: Taskova, M, Madsen, C S, Jensen, K J, Hansen, L H, Vester, B & Astakhova, K 2017, ' Antisense Oligonucleotides Internally Labeled with Peptides Show Improved Target Recognition and Stability to Enzymatic Degradation ', Bioconjugate Chemistry, vol. 28, no. 3, pp. 768-774 . https://doi.org/10.1021/acs.bioconjchem.6b00567

Specific target binding and stability in diverse biological media is of crucial importance for applications of synthetic oligonucleotides as diagnostic and therapeutic tools. So far, these issues have been addressed by chemical modification of oligon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2eaa8c94f2146b59dad3427249f8893
https://doi.org/10.1021/acs.bioconjchem.6b00567

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Combined Effect of the Cfr Methyltransferase and Ribosomal Protein L3 Mutations on Resistance to Ribosome-Targeting Antibiotics

Autor: Kevin K Pakula, Birte Vester, Lykke Haastrup Hansen

Publikováno v: Pakula, K K, Hansen, L H & Vester, B 2017, ' Combined Effect of the Cfr Methyltransferase and Ribosomal Protein L3 Mutations on Resistance to Ribosome-Targeting Antibiotics ', Antimicrobial Agents and Chemotherapy, vol. 61, no. 9, e00862-17 . https://doi.org/10.1128/AAC.00862-17

Several groups of antibiotics inhibit bacterial growth by binding to bacterial ribosomes. Mutations in ribosomal protein L3 have been associated with resistance to linezolid and tiamulin, which both bind at the peptidyl transferase center in the ribo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576ce0863a98480c607d9b52249c1c30
https://doi.org/10.1128/aac.00862-17

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A cfr -Like Gene from Clostridium difficile Confers Multiple Antibiotic Resistance by the Same Mechanism as the cfr Gene

Autor: Lykke Haastrup Hansen, Birte Vester

Publikováno v: Hansen, L H & Vester, B 2015, ' A cfr-Like Gene from Clostridium difficile Confers Multiple Antibiotic Resistance by the Same Mechanism as the cfr Gene ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 9, pp. 5841-3 . https://doi.org/10.1128/AAC.01274-15

The Cfr RNA methyltransferase causes multiple resistances to peptidyl transferase inhibitors by methylation of A2503 23S rRNA. Many cfr -like gene sequences in the databases code for unknown functions. This study confirms that a Cfr-like protein from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e90b6f1a0162ec983365c8261f3f48b
https://doi.org/10.1128/aac.01274-15

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Resistance to Linezolid

Autor: Birte Vester, Eleni Ntokou

Publikováno v: Vester, B & Ntokou, E 2017, Resistance to Linezolid . in D L Mayers, J D Sobel, M Ouellette, K S Kaye & D Marchaim (eds), Antimicrobial Drug Resistance : Mechanisms of Drug Resistance, Volume 1 . 2 edn, vol. 1, Springer, pp. 319-332 . https://doi.org/10.1007/978-3-319-46718-4_22
Antimicrobial Drug Resistance ISBN: 9783319467160

Linezolid is an antimicrobial agent that binds to the bacterial ribosomeand thereby inhibits protein synthesis. Soon after its release as aclinical drug, it became clear that bacteria could become resistant tolinezolid. The resistance mechanisms are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6afcb8a17fcfa5c15438689831bbce4
https://findresearcher.sdu.dk:8443/ws/files/126215170/Antimicrobial_Drug_Resistance.pdf

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