Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Birsen, Tozkoparan"'
Autor:
Deniz Cansen Kahraman, Ebru Bilget Guven, Peri S. Aytac, Gamze Aykut, Birsen Tozkoparan, Rengul Cetin Atalay
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional and targeted chemotherapy. Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to decrease the incidence and mortality of
Externí odkaz:
https://doaj.org/article/de9102c153df4f01a413d6729442aabf
Publikováno v:
Acta Medica. 53:251-260
Objective: Polypharmacology, interaction of one drug with multiple targets, emerged as an effective approach in drug discovery and development. Bioinformatics and cheminformatics methods are essential tools for determination of polypharmacological pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74f37d8fef199ae830fcac25637f04a2
https://doi.org/10.32552/2022.actamedica.737
https://doi.org/10.32552/2022.actamedica.737
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1340-1347
Background: Although transplantation, surgical resection, and tumor ablation are treatment options available following early diagnosis of HCC, poor prognosis and high recurrence rates restrict the efficacy of these approaches. Hence, small molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fec5b38a285c86419cd9af880ad148b
https://doi.org/10.2174/1871520621666210623093550
https://doi.org/10.2174/1871520621666210623093550
Autor:
Deniz Cansen Kahraman, Ebru Bilget Guven, Peri S. Aytac, Gamze Aykut, Birsen Tozkoparan, Rengul Cetin Atalay
Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional and targeted chemotherapy. (NSAIDs) Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to decrease the incidence and mortality of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3c57a6f7d08b57c4d8523b389bbb2a4
https://doi.org/10.21203/rs.3.rs-1025268/v1
https://doi.org/10.21203/rs.3.rs-1025268/v1
Publikováno v:
Powder Diffraction. 32:271-278
The 3-[1-(6-methoxy-2-naphtyl)ethyl]-6-(2,4-dichlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine, C23H18Cl2N4OS compound was synthesized, as a member of the family of novel potential anticancer agents. The structure of the title compound was ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::021ae5ebda8f448ff2efb53c4d25d2d3
https://doi.org/10.1017/s0885715617001099
https://doi.org/10.1017/s0885715617001099
Publikováno v:
Powder Diffraction. 32:279-289
Two novel compounds, 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16F2N4S) (1) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16ClFN4S) (2), hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b53bf0abdf2f50ca475e3c72f93add62
https://doi.org/10.1017/s0885715617001105
https://doi.org/10.1017/s0885715617001105
3-[1-[4-(2-Methylpropyephenyl] ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo [3,4-b] -1,3,4-thiadiazole (C21H21FN4S) has been synthesized as a member of a series of triazolothiadiazoles having NSAIDs moieties with cytotoxic activity. The crystal structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989cbf67913742e072016b04e3c15acc
https://hdl.handle.net/11491/6826
https://hdl.handle.net/11491/6826
Publikováno v:
Cancer Research. 79:995-995
Hepatocellular carcinoma (HCC) is the fifth most common and the second lethal cancer worldwide. HCC is resistant to conventional chemotherapy and radiotherapy due to its highly heterogenous structure. Therefore, it is crucial to design and develop no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88cd87d490b3a3384fc46e8039323d00
https://doi.org/10.1158/1538-7445.am2019-995
https://doi.org/10.1158/1538-7445.am2019-995
Autor:
Ahmet Avci, Hayrünnisa Taşci, Birsen Tozkoparan, Özgür Devrim Can, Ümmühan Kandemir, Nesrin Gökhan-Kelekçi
Publikováno v:
Bioorganic Chemistry. 100:103892
WOS: 000540959600007
PubMed: 32388433
…
Hacettepe University Scientific Research Projects Coordination Unit, Ankara, TurkeyHacettepe University [THD-2018-16721]
This study was supported by Hacettepe University Scientific Researc
PubMed: 32388433
…
Hacettepe University Scientific Research Projects Coordination Unit, Ankara, TurkeyHacettepe University [THD-2018-16721]
This study was supported by Hacettepe University Scientific Researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38deacadb2dc4b715b584311b54951c3
https://doi.org/10.1016/j.bioorg.2020.103892
https://doi.org/10.1016/j.bioorg.2020.103892
Autor:
Seyma, Sert-Ozgur, Banu C, Tel, Elif I, Somuncuoglu, Inci, Kazkayasi, Mevlut, Ertan, Birsen, Tozkoparan
Publikováno v:
Archiv der Pharmazie. 350(7)
Previously, we demonstrated that certain heterocyclic compounds derived from 3-substituted-1,2,4-triazole-5-thiones had promising analgesic/anti-inflammatory activities together with low ulcerogenic properties. Therefore, we sought to design and synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5607475d2d8c7a7be7f81ab8829ea0c
https://pubmed.ncbi.nlm.nih.gov/28594090
https://pubmed.ncbi.nlm.nih.gov/28594090