1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage

Autor: Han Xie, Isinsu Bastepe, Wen Zhou, Birol Ay, Zara Ceraj, Ignacio A. Portales-Castillo, Eva S. Liu, Sherri-Ann M. Burnett-Bowie, Harald Jüppner, Eugene P. Rhee, Murat Bastepe, Petra Simic

Publikováno v: JCI Insight, Vol 8, Iss 17 (2023)

Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of

Externí odkaz: https://doaj.org/article/b06b80cae0e94772ab23ca6c29508e95

Maternal GNAS Contributes to the Extra-Large G Protein α-Subunit (XLαs) Expression in a Cell Type-Specific Manner

Autor: Qiuxia Cui, Cagri Aksu, Birol Ay, Claire E. Remillard, Antonius Plagge, Mina Gardezi, Margaret Dunlap, Louis C. Gerstenfeld, Qing He, Murat Bastepe

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

GNAS encodes the stimulatory G protein alpha-subunit (Gsα) and its large variant XLαs. Studies have suggested that XLαs is expressed exclusively paternally. Thus, XLαs deficiency is considered to be responsible for certain findings in patients wi

Externí odkaz: https://doaj.org/article/d9a3aa92a4074764a4d26e488c2cd8e9

Maternal GNAS Contributes to the Extra-Large G Protein α-Subunit (XLαs) Expression in a Cell Type-Specific Manner

Autor: Murat Bastepe, Cagri Aksu, Quixia Cui, Margaret Dunlap, Claire E Remillard, Louis C. Gerstenfeld, Mina Gardezi, Birol Ay, Antonius Plagge, Qing He

Publikováno v: Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics

GNAS encodes the stimulatory G protein alpha-subunit (Gsα) and its large variant XLαs. Studies have suggested that XLαs is expressed exclusively paternally. Thus, XLαs deficiency is considered to be responsible for certain findings in patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9153bedcdd422a965d0da1bc6616b1c3
https://www.frontiersin.org/articles/10.3389/fgene.2021.680537/full

Skeletal muscle patch engineering on synthetic and acellular human skeletal muscle originated scaffolds

Autor: Birol Ay, Halime Kenar, Erdal Karaoz, Cumhur Cevdet Kesemenli

Publikováno v: Journal of Biomedical Materials Research Part A. 105:879-890

The reconstruction of skeletal muscle tissue is currently performed by transplanting a muscle tissue graft from local or distant sites of the patient's body, but this practice leads to donor site morbidity in case of large defects. With the aim of pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5d1f723843760da277a70b898e42a0b
https://doi.org/10.1002/jbm.a.35948

Exploring the mechanism behind improved osteointegration of phosphorylated titanium implants with hierarchically structured topography

Autor: Nan Jiang, Li Zhang, Birol Ay, Yubao Li, Dan Sun, Yutao Yang, Zhijun Guo, Peijie Tan, Songsong Zhu

Publikováno v: Jiang, N, Guo, Z, Sun, D, Ay, B, Li, Y, Yang, Y, Tan, P, Zhang, L & Zhu, S 2019, ' Exploring the mechanism behind improved osteointegration of phosphorylated titanium implants with hierarchically structured topography ', COLLOIDS AND SURFACES B-BIOINTERFACES, vol. 184, 110520 . https://doi.org/10.1016/j.colsurfb.2019.110520

Titanium (Ti) and its alloys have been frequently used in dental and orthopedic implants, but the undesired oxide layer easily formed on the surface tends to be the cause of implant failure for Ti-based implants. To address this problem, we herein pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aee1b252515af0443cfeacec73c16c
https://pubmed.ncbi.nlm.nih.gov/31590052