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Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice.

Autor: Birkisdóttir, María B.¹ (AUTHOR), Jaarsma, Dick² (AUTHOR), Brandt, Renata M. C.³ (AUTHOR), Barnhoorn, Sander³ (AUTHOR), Vliet, Nicole³ (AUTHOR), Imholz, Sandra⁴ (AUTHOR), Oostrom, Conny T.⁴ (AUTHOR), Nagarajah, Bhawani⁴ (AUTHOR), Portilla Fernández, Eliana⁵ (AUTHOR), Roks, Anton J. M.⁵ (AUTHOR), Elgersma, Ype² (AUTHOR), Steeg, Harry⁴ (AUTHOR), Ferreira, José A.⁶ (AUTHOR), Pennings, Jeroen L. A.⁴ (AUTHOR), Hoeijmakers, Jan H. J.^1,3,7 (AUTHOR), Vermeij, Wilbert P.¹ (AUTHOR) W.P.Vermeij@prinsesmaximacentrum.nl, Dollé, Martijn E. T.⁴ (AUTHOR) Martijn.Dolle@rivm.nl

Publikováno v: Aging Cell. Feb2021, Vol. 20 Issue 2, p1-17. 17p.

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside.

Autor: Birkisdóttir, María B., van Galen, Ivar, Brandt, Renata M. C., Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T., Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G., Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H. J., Dollé, Martijn E. T., Vermeij, Wilbert P.

Publikováno v: Frontiers in Aging; 10/12/2022, p1-12, 12p