Výsledky vyhledávání - "Birkholtz Lyn-Marie"

Akademický článek

Sustainable malaria control: transdisciplinary approaches for translational applications

Autor: Birkholtz Lyn-Marie, Bornman Riana, Focke Walter, Mutero Clifford, de Jager Christiaan

Publikováno v: Malaria Journal, Vol 11, Iss 1, p 431 (2012)

Abstract With the adoption of the Global Malaria Action Plan, several countries are moving from malaria control towards elimination and eradication. However, the sustainability of some of the approaches taken may be questionable. Here, an overview of

Externí odkaz: https://doaj.org/article/08e2c5df120940b1822fc0c288d2de36

Zobrazit plný text záznamu

Akademický článek

Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

Autor: Louw Abraham I, Reeksting Shaun, van Brummelen Anna C, Stoychev Stoyan, Crampton Bridget G, Mtwisha Linda, Becker John VW, Birkholtz Lyn-Marie, Mancama Dalu T

Publikováno v: BMC Genomics, Vol 11, Iss 1, p 235 (2010)

Abstract Background Plasmodium falciparum, the causative agent of severe human malaria, has evolved to become resistant to previously successful antimalarial chemotherapies, most notably chloroquine and the antifolates. The prevalence of resistant st

Externí odkaz: https://doaj.org/article/a14db1ee4967445b9471ae3e398c320c

Zobrazit plný text záznamu

Akademický článek

Heterologous expression of plasmodial proteins for structural studies and functional annotation

Autor: Oldfield Lyndon, Ngcete Zoleka, Morris Elizabeth J, Human Esmaré, Hoppe Heinrich C, Coetzer Theresa L, Blatch Gregory, Birkholtz Lyn-Marie, Roth Robyn, Shonhai Addmore, Stephens Linda, Louw Abraham I

Publikováno v: Malaria Journal, Vol 7, Iss 1, p 197 (2008)

Abstract Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of Plasmodium parasites to the cost-effective chloroquine and antifolates ha

Externí odkaz: https://doaj.org/article/57fa1ac05cf94db99d6cf7f841eaa2b7

Zobrazit plný text záznamu

Akademický článek

Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study

Autor: Birkholtz Lyn-Marie, Louw Abraham I, Williams Marni

Publikováno v: Malaria Journal, Vol 6, Iss 1, p 64 (2007)

Abstract Background The increasing emergence of Plasmodium falciparum parasites resistant to most of the cost-effective drugs has necessitated the identification of novel leads and drug targets. Parasite-specific inserts in enzymes that are essential

Externí odkaz: https://doaj.org/article/820a7859b1b04f8ea8dcf4932d1e6546

Zobrazit plný text záznamu

Akademický článek

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

Autor: Hofmann-Apitius Martin, Roy Sylvaine, Saïdani Nadia, Jacq Nicolas, Ortet Philippe, Zimmermann Marc, Kasam Vinod, Joubert Fourie, Grando Delphine, Wells Gordon, Bastien Olivier, Birkholtz Lyn-Marie, Breton Vincent, Louw Abraham I, Maréchal Eric

Publikováno v: Malaria Journal, Vol 5, Iss 1, p 110 (2006)

Abstract The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to predict and characteriz

Externí odkaz: https://doaj.org/article/dfa6e43edfd441198f993e71b60865f2

Zobrazit plný text záznamu