Field Cancerization Is Associated with Tumor Development, T-cell Exhaustion, and Clinical Outcomes in Bladder Cancer

Autor: Strandgaard, Trine, Nordentoft, Iver, Birkenkamp-Demtröder, Karin, Salminen, Liina, Prip, Frederik, Rasmussen, Julie, Andreasen, Tine Ginnerup, Lindskrog, Sia Viborg, Christensen, Emil, Lamy, Philippe, Knudsen, Michael, Steiniche, Torben, Jensen, Jørgen Bjerggaard, Dyrskjøt, Lars

Publikováno v: In European Urology January 2024 85(1):82-92

SPTAN1, APC, and FGFR3 Mutation Status and APOBEC Mutation Signatures are Predictive of Mitomycin C Response in Non-muscle-invasive Bladder Cancer

Autor: Maria Skydt Lindgren, Philippe Lamy, Sia Viborg Lindskrog, Emil Christensen, Iver Nordentoft, Karin Birkenkamp-Demtröder, Benedicte Parm Ulhøi, Jørgen Bjerggaard Jensen, Lars Dyrskjøt

Publikováno v: European Urology Open Science, Vol 34, Iss , Pp 59-67 (2021)

Background: Currently, no biomarkers of response to mitomycin C have been identified in non–muscle-invasive bladder cancer patients. Predictive biomarkers could improve the treatment outcome and eliminate adverse events from unnecessary treatment.

Externí odkaz: https://doaj.org/article/cd3a3e87712f4f219e9ee36ad73e8d7d

An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

Autor: Sia Viborg Lindskrog, Frederik Prip, Philippe Lamy, Ann Taber, Clarice S. Groeneveld, Karin Birkenkamp-Demtröder, Jørgen Bjerggaard Jensen, Trine Strandgaard, Iver Nordentoft, Emil Christensen, Mateo Sokac, Nicolai J. Birkbak, Lasse Maretty, Gregers G. Hermann, Astrid C. Petersen, Veronika Weyerer, Marc-Oliver Grimm, Marcus Horstmann, Gottfrid Sjödahl, Mattias Höglund, Torben Steiniche, Karin Mogensen, Aurélien de Reyniès, Roman Nawroth, Brian Jordan, Xiaoqi Lin, Dejan Dragicevic, Douglas G. Ward, Anshita Goel, Carolyn D. Hurst, Jay D. Raman, Joshua I. Warrick, Ulrika Segersten, Danijel Sikic, Kim E. M. van Kessel, Tobias Maurer, Joshua J. Meeks, David J. DeGraff, Richard T. Bryan, Margaret A. Knowles, Tatjana Simic, Arndt Hartmann, Ellen C. Zwarthoff, Per-Uno Malmström, Núria Malats, Francisco X. Real, Lars Dyrskjøt

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated

Externí odkaz: https://doaj.org/article/25de5d15c38f4468b633c9e4bdca4e8d

Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

Autor: Ann Taber, Emil Christensen, Philippe Lamy, Iver Nordentoft, Frederik Prip, Sia Viborg Lindskrog, Karin Birkenkamp-Demtröder, Trine Line Hauge Okholm, Michael Knudsen, Jakob Skou Pedersen, Torben Steiniche, Mads Agerbæk, Jørgen Bjerggaard Jensen, Lars Dyrskjøt

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a n

Externí odkaz: https://doaj.org/article/3885a19d3a524eca9c7327f222740721

Cell-Free Urine and Plasma DNA Mutational Analysis Predicts Neoadjuvant Chemotherapy Response and Outcome in Patients with Muscle-Invasive Bladder Cancer

Autor: Emil Christensen, Iver Nordentoft, Karin Birkenkamp-Demtröder, Sara K. Elbæk, Sia V. Lindskrog, Ann Taber, Tine G. Andreasen, Trine Strandgaard, Michael Knudsen, Philippe Lamy, Mads Agerbæk, Jørgen B. Jensen, Lars Dyrskjøt

Publikováno v: Christensen, E, Nordentoft, I, Birkenkamp-Demtroder, K, Elbæk, S K, Lindskrog, S V, Taber, A, Andreasen, T G, Strandgaard, T, Knudsen, M, Lamy, P, Agerbæk, M, Jensen, J B & Dyrskjøt, L 2023, ' Cell-free urine-and plasma DNA mutational analysis predicts neoadjuvant chemotherapy response and outcome in patients with muscle invasive bladder cancer ', Clinical Cancer Research, vol. 29, no. 8, pp. 1582–1591 . https://doi.org/10.1158/1078-0432.CCR-22-3250

Purpose: To investigate the use of plasma and urine DNA mutation analysis for predicting neoadjuvant chemotherapy (NAC) response and oncological outcome in patients with muscle-invasive bladder cancer. Experimental Design: Whole-exome sequencing of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf1f58ca57cdc96542ccdf2f65dc41d
https://doi.org/10.1158/1078-0432.ccr-22-3250