Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells

Autor: Christy B. M. Tulen, Cheryl van de Wetering, Caspar H. J. Schiffers, Ellen Weltjens, Birke J. Benedikter, Pieter A. Leermakers, Juliana H. Boukhaled, Marie-José Drittij, Bernd T. Schmeck, Niki L. Reynaert, Antoon Opperhuizen, Frederik-Jan van Schooten, Alexander H. V. Remels

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract Abnormal mitochondria have been observed in bronchial- and alveolar epithelial cells of patients with chronic obstructive pulmonary disease (COPD). However, it is unknown if alterations in the molecular pathways regulating mitochondrial turn

Externí odkaz: https://doaj.org/article/0db4c07e4b22467d8642273fe6ed38c9

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Autor: Björn Klabunde, André Wesener, Wilhelm Bertrams, Isabell Beinborn, Nicole Paczia, Kristin Surmann, Sascha Blankenburg, Jochen Wilhelm, Javier Serrania, Kèvin Knoops, Eslam M. Elsayed, Katrin Laakmann, Anna Lena Jung, Andreas Kirschbaum, Sven Hammerschmidt, Belal Alshaar, Nicolas Gisch, Mobarak Abu Mraheil, Anke Becker, Uwe Völker, Evelyn Vollmeister, Birke J. Benedikter, Bernd Schmeck

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Lower respiratory tract infections caused by Streptococcus pneumoniae (Spn) are a leading cause of death globally. Here we investigate the bronchial epithelial cellular response to Spn infection on a transcriptomic, proteomic and metabolic l

Externí odkaz: https://doaj.org/article/f53e17d7ffee4a8b866fd16db80c5bb8

Mitochondrial DNA D-loop variants correlate with a primary open-angle glaucoma subgroup

Autor: Antoni Vallbona-Garcia, Patrick J. Lindsey, Rick Kamps, Alphons P. M. Stassen, Nhan Nguyen, Florence H. J. van Tienen, Ilse H. J. Hamers, Rianne Hardij, Marike W. van Gisbergen, Birke J. Benedikter, Irenaeus F. M. de Coo, Carroll A. B. Webers, Theo G. M. F. Gorgels, Hubert J. M. Smeets

Publikováno v: Frontiers in Ophthalmology, Vol 3 (2024)

IntroductionPrimary open-angle glaucoma (POAG) is a characteristic optic neuropathy, caused by degeneration of the optic nerve-forming neurons, the retinal ganglion cells (RGCs). High intraocular pressure (IOP) and aging have been identified as major

Externí odkaz: https://doaj.org/article/6d3868ee3c8f44a88fd87508edffd404

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Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Autor: Welsh, Joshua A., Goberdhan, Deborah C. I., O’Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A. P., Erdbrügger, Uta, Falcon-Perez, Juan M., Fu, Qing-Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, M.y.G., Mohanty, Sujata, Möller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco, Burger, Dylan, Carney, Randy P., Cocucci, Emanuele, Crescitelli, Rossella, Hanser, Edveena, Harris, Adrian L., Haughey, Norman J., Hendrix, An, Ivanov, Alexander R., Jovanovic-Talisman, Tijana, Kruh-Garcia, Nicole A., Faustino, Vroniqa Ku’ulei-Lyn, Kyburz, Diego, Lässer, Cecilia, Lennon, Kathleen M., Lötvall, Jan, Maddox, Adam L., Martens-Uzunova, Elena S., Mizenko, Rachel R., Newman, Lauren A., Ridolfi, Andrea, Rohde, Eva, Rojalin, Tatu, Rowland, Andrew, Saftics, Andras, Sandau, Ursula S., Saugstad, Julie A., Shekari, Faezeh, Swift, Simon, Ter-Ovanesyan, Dmitry, Tosar, Juan P., Useckaite, Zivile, Valle, Francesco, Varga, Zoltan, van der Pol, Edwin, van Herwijnen, Martijn J. C., Wauben, Marca H. M., Wehman, Ann M., Williams, Sarah, Zendrini, Andrea, Zimmerman, Alan J., Théry, Clotilde, Witwer, Kenneth W., Ahmad, Samar, Ahmed, Dina A. K., Ahmed, Sarah H., Aikawa, Elena, Akbar, Naveed, Akiyoshi, Kazunari, Al-Adra, David P., Al-Masawa, Maimonah E., Albanese, Manuel, Alberro, Ainhoa, Alcaraz, María José, Alexander-Brett, Jen, Alexander, Kimberley L., Ali, Nilufar, Alibhai, Faisal J., Allelein, Susann, Allenby, Mark C., Almeida, Fausto, de Almeida, Luis Pereira, Almousa, Sameh W., Altan-Bonnet, Nihal, Altei, Wanessa F., Alvarez-Llamas, Gloria, Alvarez, Cora L., An, Hyo Jung, Anand, Krishnan, Andaloussi, Samir E. L., Anderson, Johnathon D., Andriantsitohaina, Ramaroson, Ansari, Khairul I., Anselmo, Achille, Antoniou, Anna, Aqil, Farrukh, Arab, Tanina, Archer, Fabienne, Arif, Syrine, Armstrong, David A., Arntz, Onno J., Arsène, Pierre, Arteaga-Blanco, Luis, Asokan, Nandini, Aspelin, Trude, Atkin-Smith, Georgia K., Aubert, Dimitri, Ayyar, Kanchana K., Azlan, Maryam, Azoidis, Ioannis, Bécot, Anaïs, Bach, Jean-Marie, Bachurski, Daniel, Bae, Seoyoon, Bagge, Roger Olofsson, Baj-Krzyworzeka, Monika, Balaj, Leonora, Balbi, Carolina, van Balkom, Bas W. 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M., Buratta, Sandra, Burgy, Olivier, Burnier, Julia V., Burrows, Kaiping, Busatto, Sara, Buzas, Krisztina, Byrd, J. Brian, Cáceres-Verschae, Albano, Caires, Hugo R., Campos-Silva, Carmen, Camussi, Giovanni, de Candia, Paola, Carceller, Carmen, Fernandez-Becerra, Carmen, Carrasco, Alexis G. Murillo, Carter, David R. F., Cavallaro, Sara, Cavallero, Serena, Cavallero, Sophie, Cerda-Troncoso, Cristóbal, Chahwan, Richard, Chalupská, Renata, Chamley, Lawrence W., Chandra, Partha K., Chang, Wen-Wei, Charest, Al, Chen, Chihchen, Chen, Hao, Chen, Qiang, Chen, Shuai, Chen, Siyu, Chen, Yunxi, Cheng, Lesley, Chernyshev, Vasiliy S., Chetty, Venkatesh Kumar, Chitti, Sai V., Cho, Ssang-Goo, Cho, Yoon-Kyoung, Choi, Byeong Hyeon, Chutipongtanate, Somchai, Cicardi, Maria Elena, Cifuentes-Rius, Anna, Ciullo, Alessandra, Clayton, Aled, Cleary, Jacob A., Cocozza, Federico, Coffey, Robert J., Collino, Federica, Colombo, Federico, Colosetti, Pascal, Compañ-Bertomeu, Alvaro, Constanzo, Julie, Corbeil, Denis, Cordeiro-da-Silva, Anabela, Costa, Júlia, Couch, Yvonne, Courageux, Yvan, Coutant, Kelly, Coyle, Beth, Cretich, Marina, Cronemberger-Andrade, André, Crossland, Rachel E., Cucher, Marcela A., Czystowska-Kuzmicz, Malgorzata, D’Acunzo, Pasquale, D’Agnano, Igea, D’Agostino, Vito G., D’Arrigo, Daniele, D’Souza-Schorey, Crislyn, Dagur, Raghubendra S., Danielson, Kirsty M., Das, Saumya, Dauphin, Thibaud, Davidson, Sean M., Davies, Owen G., Davies, Rebecca L., Davis, Chelsea N., Deep, Gagan, Degosserie, Jonathan, Van Delen, Mats, Deliwala, Vatsal, Dellar, Elizabeth R., Van Deun, Jan, Dev, Apurba, Deville, Sarah, Devitt, Andrew, Dhondt, Bert, Dieterich, Lothar C., Dittmer, Dirk P., Dobosh, Brian, Dobra, Gabriella, Dogra, Navneet, Dohi, Eisuke, Dolo, Vincenza, Domashevich, Timothy V., Dominici, Massimo, Dong, Liang, Doré, Etienne, Dragovic, Rebecca A., Drittanti, Lila, Droste, Marvin, Duan, Wei, Durmaz, Esmahan, Dutta, Suman, Eguchi, Takanori, Eichenberger, Ramon M., Eitan, Erez, Ekström, Karin, Eldh, Maria, Elie-Caille, Celine, Enciso-Martinez, Agustin, Esmaeili, Rezvan, Ettelaie, Camille, Försönits, András I., Fabbri, Muller, Falasca, Marco, Fan, Hongkuan, Fatima, Farah, Fazeli, Alireza, Fernández-Rhodes, María, Fernandez-Prada, Christopher, Ferraro, Mariola J., Ferreira, Joaon, Ferreira, Rafaela F., Figueroa-Hall, Leandra K., Figueroa-Valdés, Aliosha I., Fioretti, Paolo V., Flenady, Sabine, Flores-Bellver, Miguel, Fok, Ellis K., Fonseka, Pamali, Forbes, Karen, Ford, Verity J., Fornaguera, Cristina, Forte, Dorian, Forte, Stefano, Fortunato, Orazio, Franklin, Jeffrey L., Freitas, Daniela, Frelet-Barrand, Annie, Fujita, Yu, Gärtner, Kathrin, Görgens, André, Gabriel, Áurea M., Gabrielli, Martina, Gabrielsson, Susanne, Galinsoga, Alicia, Galisova, Andrea, Gamage, Teena K. 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M., Holcar, Marija, Holder, Beth, Holnthoner, Wolfgang, Holthofer, Harry, Hooper, D. Craig, Hosseini-Beheshti, Elham, Hosseinkhani, Baharak, Howard, Jane, Howe, Kathryn L., Hoyle, Nicholas R., Hrdy, Jiri, Hu, Guoku, Huang, Yiyao, Huber, Veronica, Hudoklin, Samo, Hufnagel, Antonia, Hulett, Mark D., Hunt, Stuart, Hyenne, Vincent, Di Ianni, Emilio, Iannotta, Dalila, Ibrahim, Ahmed G. E., Ibrahim, Sherif A., Ikezu, Seiko, Ikezu, Tsuneya, Im, Hyungsoon, Inal, Jameel M., Inic-Kanada, Aleksandra, Inngjerdingen, Marit, Inoshima, Yasuo, Ivanova, Alena, Izquierdo, Elena, Jørgensen, Malene Møller, Jackson, Hannah K., Jacobsen, Soren, Jadue, Fernanda, Javeed, Naureen, Jay, Steven M., Jayachandran, Muthuvel, Jayasinghe, Migara K., Jenster, Guido, Jeppesen, Dennis K., Jerónimo, Carmen, Jiang, Linglei, Jin, Jing, Jingushi, Kentaro, Jo, Dong-Gyu, Joerger-Messerli, Marianne S., Jones, Jennifer C., Jones, Melissa K., de Jong, Olivier G., Ferrante, Anthony W., Coleman, Leon G., Juncker, David, Jung, Stephanie, Jurek, Benjamin, Jurga, Marcin, Justilien, Verline, Kabani, Mehdi, Kalluri, Raghu, Kamali-Moghaddam, Masood, Kanada, Masamitsu, Kang, Taeyoung, Kano, Shin-Ichi, Kaparakis-Liaskos, Maria, Karnas, Elżbieta, Karoichan, Antoine, Kashanchi, Fatah, Kashani, Sara Assar, Kashyap, Namita N., Katsur, Miroslava, Kau-Strebinger, Silvio, Kauffman, Amy C., Kaur, Sukhbir, Kehoe, Oksana, Kelwick, Richard J. R., Kenari, Amirmohammad Nasiri, Kestecher, Brachyahu M., Keulers, Tom G., Van Keuren-Jensen, Kendall R., Khalaj, Kasra, Khamari, Delaram, Khanabdali, Ramin, Khomyakova, Elena, Khoo, Amanda, Kim, Daniel H., Kim, Dongin, Kim, Han Sang, Kim, In-San, Kim, Soo, Kim, Yohan, Kima, Peter E., Kislinger, Thomas, Klingeborn, Mikael, Knight, Rob, Komuro, Hiroaki, Koncz, Anna, Konstantinou, Timothea, van der Koog, Luke, Kooijmans, Sander AA, Kornek, Miroslaw T., Kosanović, Maja, Kostallari, Enis, Koukoulis, Tiana F., Kourembanas, Stella, Krämeralbers, Eva-Maria, Kralj-Iglic, Veronika, Krasemann, Susanne, Krasnodembskaya, Anna D., Krawczynska, Natalia J., Kreft, Mateja E., Kuehn, Meta J., Kuipers, Marije E., Kulaj, Konxhe, Kuligowski, Julia, Kumagai, Yumi, Kumar, Ashish, Kumar, Saroj, Kumar, Sharad, Kumari, Meena, Kundrotas, Gabrielis, Kurochkin, Igor V., Kuroda, Masahiko, Kurzawa-Akanbi, Marzena, Kweskin, Sasha J., Lázaro-Ibáñez, Elisa, Lőrincz, Ákosm, Lai, Andrew, Lai, Charles P., Laitinen, Saara, Landreville, Solange, Lange, Sigrun, Langevin, Scott M., Langlois, Marc-André, Languino, Lucia R., Lannigan, Joanne, Lark, Daniel S., Larregina, Adriana T., Laurent, Louise C., Laurin, David, Lavieu, Gregory, Lawson, Charlotte, Le Lay, Soazig, Leandro, Kevin, Ledreux, Aurélie, Lee, Changjin, Lee, Dong-Sup, Lee, Hakho, Lee, Heonjin, Lee, Sun Young, Lee, Tae Ryong, Lee, Wai-Leng, Lefterov, Iliya, Lei, Xinhua, Leivo, Janne, Lemaire, Quentin, Leme, Adriana F Paes, Lemon, Stanley M., Lenzini, Stephen, Leor, Jonathan, Levy, Efrat, Li, Bo, Li, Guoping, Li, Jiao Jiao, Li, Qiubai, Li, Xinlei, Liang, Xiuming, Lim, Rebecca, Limongi, Tania, Linē, Aija, Lins, Paula Pincela, Lippens, Lien, Liu, Guanshu, Llorente Martinez, Alicia, Longjohn, Modeline N., van de Loo, Fons A. 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Publikováno v: Welsh, Joshua A. Goberdhan, Deborah C. I. O’Driscoll, Lorraine Buzas, Edit I. Blenkiron, Cherie Bussolati, Benedetta Cai, Houjian Di Vizio, Dolores Driedonks, Tom A. P. Erdbrügger, Uta Falcon-Perez, Juan M. Fu, Qing-Ling Hill, Andrew F. Lenassi, Metka Lim, Sai Kiang Mahoney, M.y.G. Mohanty, Sujata Möller, Andreas Nieuwland, Rienk Ochiya, Takahiro Sahoo, Susmita Torrecilhas, Ana C. Zheng, Lei Zijlstra, Andries Abuelreich, Sarah Bagabas, Reem Bergese, Paolo Bridges, Esther M. Brucale, Marco Burger, Dylan Carney, Randy P. Cocucci, Emanuele Crescitelli, Rossella Hanser, Edveena Harris, Adrian L. Haughey, Norman J. Hendrix, An Ivanov, Alexander R. Jovanovic-Talisman, Tijana Kruh-Garcia, Nicole A. Faustino, Vroniqa Ku’ulei-Lyn Kyburz, Diego Lässer, Cecilia Lennon, Kathleen M. Lötvall, Jan Maddox, Adam L. Martens-Uzunova, Elena S. Mizenko, Rachel R. Newman, Lauren A. Ridolfi, Andrea Rohde, Eva Rojalin, Tatu Rowland, Andrew Saftics, Andras Sandau, Ursula S. Saugstad, Julie A. Shekari, Faezeh Swift, Simon Ter-Ovanesyan, Dmitry Tosar, Juan P. Useckaite, Zivile Valle, Francesco Varga, Zoltan van der Pol, Edwin van Herwijnen, Martijn J. C. Wauben, Marca H. M. Wehman, Ann M. Williams, Sarah Zendrini, Andrea Zimmerman, Alan J. Théry, Clotilde Witwer, Kenneth W. Ahmad, Samar Ahmed, Dina A. K. Ahmed, Sarah H. Aikawa, Elena Akbar, Naveed Akiyoshi, Kazunari Al-Adra, David P. Al-Masawa, Maimonah E. Albanese, Manuel Alberro, Ainhoa Alcaraz, María José Alexander-Brett, Jen Alexander, Kimberley L. Ali, Nilufar Alibhai, Faisal J. Allelein, Susann Allenby, Mark C. Almeida, Fausto de Almeida, Luis Pereira Almousa, Sameh W. Altan-Bonnet, Nihal Altei, Wanessa F. Alvarez-Llamas, Gloria Alvarez, Cora L. An, Hyo Jung Anand, Krishnan Andaloussi, Samir E. L. Anderson, Johnathon D. Andriantsitohaina, Ramaroson Ansari, Khairul I. Anselmo, Achille Antoniou, Anna Aqil, Farrukh Arab, Tanina Archer, Fabienne Arif, Syrine Armstrong, David A. Arntz, Onno J. Arsène, Pierre Arteaga-Blanco, Luis Asokan, Nandini Aspelin, Trude Atkin-Smith, Georgia K. Aubert, Dimitri Ayyar, Kanchana K. Azlan, Maryam Azoidis, Ioannis Bécot, Anaïs Bach, Jean-Marie Bachurski, Daniel Bae, Seoyoon Bagge, Roger Olofsson Baj-Krzyworzeka, Monika Balaj, Leonora Balbi, Carolina van Balkom, Bas W. M. Ballal, Abhijna R. Bano, Afsareen Banzet, Sébastien Bare, Yonis Barile, Lucio Barman, Bahnisikha Barranco, Isabel Barreca, Valeria Bart, Geneviève Barteneva, Natasha S. Basso, Manuela Batish, Mona Bauer, Natalie R. Baxter, Amy A. Bazié, Wilfried W. Bazzan, Erica Beaumont, Joel EJ Bebawy, Mary Bebelman, Maarten P. Bedina-Zavec, Apolonija Beetler, Danielle J. Beke-Somfai, Tamás Belleannée, Clémence Benedikter, Birke J. Benediktsdóttir, Berglind E. Berardi, Anna C. Bergamelli, Mathilde Bertolini, Irene Bhattacharyya, Asima Bhattacharyya, Suvendra N. Biller, Steven J. Billottet, Clotilde Bissler, John J. Blanc-Brude, Olivier Blijdorp, Charles J. Bobis-Wozowicz, Sylwia Bodart-Santos, Victor Bodnár, Bernadett R. Boilard, Eric Boireau, Wilfrid Bokun, Vladimir Bollard, Stephanie M. Bollini, Sveva Bongiovanni, Antonella Bongiovanni, Laura Bonifay, Amandine Boppart, Marni D. Borràs, Francesc E. Bosch, Steffi Boselli, Daniela Bottini, Massimo Bouffard, Jeff Boulanger, Chantal M. Boutros, Paul C. Boyadjian, Oscar Boysen, Anders T. Bozkurt, Batuhan T. Bramich, Kyle P. Braun, Fabian Del Carmen Bravo-Miana, Rocío Breakefield, Xandra O. Brenna, Santra Brennan, Kieran Brennan, Meadhbh Á. Breyne, Koen Brigstock, David R. Brisson, Alain R. Brodie, Chaya Bruno, Katelyn A. Bucci, Cecilia Buch, Shilpa Buck, Amyh Bukva, Mátyás Bulte, Jeff W. M. Buratta, Sandra Burgy, Olivier B
Jo

Externí odkaz: http://hdl.handle.net/10852/114024