Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Birkan Gokbag"'
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Synthetic lethal (SL) genetic interactions have been regarded as a promising focus for investigating potential targeted therapeutics to tackle cancer. However, the costly investment of time and labor associated with wet-lab experimental screenings to
Externí odkaz:
https://doaj.org/article/555522724c9c4f8eb54c7303c3ce25b9
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Synthetic lethality (SL) refers to a genetic interaction in which the simultaneous perturbation of two genes leads to cell or organism death, whereas viability is maintained when only one of the pair is altered. The experimental exploration of these
Externí odkaz:
https://doaj.org/article/3cf16966a89b4a2091904db6bd601dca
Autor:
Shan Tang, Xue Wu, Jinghui Liu, Qiongsi Zhang, Xinyi Wang, Shuai Shao, Birkan Gokbag, Kunjie Fan, Xiaoqi Liu, Fuhai Li, Lijun Cheng, Lang Li
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101556- (2022)
Summary: Combinatorial CRISPR screening is useful for investigating synthetic lethality (SL) gene pairs. Here, we detail the steps for dual-gRNA library construction, with the introduction of two backbones, LentiGuide_DKO and LentiCRISPR_DKO. We desc
Externí odkaz:
https://doaj.org/article/b781ba81c6fb42079b2ddbbe820bbc17
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1008885 (2022)
Single-cell mass cytometry, also known as cytometry by time of flight (CyTOF) is a powerful high-throughput technology that allows analysis of up to 50 protein markers per cell for the quantification and classification of single cells. Traditional ma
Externí odkaz:
https://doaj.org/article/6ef56a305978422687a68dafec052702
Publikováno v:
PLoS computational biology. 18(4)
Single-cell mass cytometry, also known as cytometry by time of flight (CyTOF) is a powerful high-throughput technology that allows analysis of up to 50 protein markers per cell for the quantification and classification of single cells. Traditional ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2a59289a9a538a61980038c1fada41
https://pubmed.ncbi.nlm.nih.gov/35404970
https://pubmed.ncbi.nlm.nih.gov/35404970