The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity:A multicenter randomized, double-blind, clinical trial (the SPIREN trial)

Autor: Helle C. Thiesson, Line Aas Mortensen, Claus Bistrup, Birgitte Tougaard, Anne Sophie Lind Fischer, Martin Egfjord

Publikováno v: Mortensen, L A, Thiesson, H C, Tougaard, B, Egfjord, M, Fischer, A S L & Bistrup, C 2018, ' The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity : A multicenter randomized, double-blind, clinical trial (the SPIREN trial) ', BMC Nephrology, vol. 19, no. 1, 105 . https://doi.org/10.1186/s12882-018-0885-6
BMC Nephrology, Vol 19, Iss 1, Pp 1-7 (2018)
BMC Nephrology
Mortensen, L A, Thiesson, H C, Tougaard, B, Egfjord, M, Fischer, A S L & Bistrup, C 2018, ' The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity : a multicenter randomized, double-blind, clinical trial (the SPIREN trial) ', BMC Nephrology, vol. 19, no. 1, 105, pp. 1-7 . https://doi.org/10.1186/s12882-018-0885-6

BACKGROUND: Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple organs. Animal studies have in

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https://findresearcher.sdu.dk:8443/ws/files/141325192/The_effect_of_spironolactone_on_calcineurin_inhibitor_induced_nephrotoxicity.pdf