Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Birgitte S, Wulff"'
Autor:
Julie M. Jacobsen, Natalia Petersen, Lola Torz, Marina K. Gerstenberg, Kent Pedersen, Søren Østergaard, Birgitte S. Wulff, Birgitte Andersen, Kirsten Raun, Berit Ø. Christoffersen, Linu M. John, Marc L. Reitman, Rune E. Kuhre
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114501- (2024)
Summary: Evaluation of weight loss drugs is usually performed in diet-induced obese mice housed at ∼22°C. This is a cold stress that increases energy expenditure by ∼35% compared to thermoneutrality (∼30°C), which may overestimate drug-induce
Externí odkaz:
https://doaj.org/article/497a3258f3ea4cada07960619cde81b6
Autor:
Birgitte S. Wulff, Rune Ehrenreich Kuhre, Madhan Selvaraj, Jens F. Rehfeld, Kristoffer Niss, Johannes J. Fels, Secher Anna, Kirsten Raun, Marina Kjaergaard Gerstenberg
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32009- (2024)
Objective: Co-treatment with long acting PYY and the GLP-1 receptor agonists has potential as an efficient obesity treatment. This study investigates whether the mechanisms behind additive reduction of food intake and weight loss depends on complemen
Externí odkaz:
https://doaj.org/article/4c1a17d3a0794a50bafbe1ca28b42027
Autor:
Suneet Mehrotra, Sebastian Lam, Elizabeth Glenn, David Hymel, Christina A. Sanford, Qingyuan Liu, John Herich, Birgitte S. Wulff, Thomas H. Meek
Publikováno v:
ACS Bio & Med Chem Au, Vol 2, Iss 4, Pp 370-375 (2022)
Externí odkaz:
https://doaj.org/article/f58b38b72dbf4650b7df29ab0c9fd09d
Autor:
Søren Østergaard, Johan F. Paulsson, Jacob Kofoed, Franziska Zosel, Jørgen Olsen, Claus Bekker Jeppesen, Jane Spetzler, Lars Ynddal, Luise Gram Schleiss, Berit Østergaard Christoffersen, Kirsten Raun, Ulrich Sensfuss, Flemming Seier Nielsen, Rasmus Jørgensen, Birgitte S. Wulff
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long half-lives allowing for up to once-weekly dosing
Externí odkaz:
https://doaj.org/article/cec7ec4e645c44c5a30946919c1e7741
Autor:
Linu M. John, Charlotte M. Dalsgaard, Claus B. Jeppesen, Kilian W. Conde-Frieboes, Katrine Baumann, Niels P. H. Knudsen, Per S. Skov, Birgitte S. Wulff
Publikováno v:
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 30-36 (2021)
In development of peptide therapeutics, rodents are commonly-used preclinical models when screening compounds for efficacy endpoints in the early stages of discovery projects. During the screening process, some peptides administered subcutaneously to
Externí odkaz:
https://doaj.org/article/d188a47955b14068b59278fe6234d454
Autor:
Anna Secher, Christian D. Kelstrup, Kilian W. Conde-Frieboes, Charles Pyke, Kirsten Raun, Birgitte S. Wulff, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Neuropeptide research is challenged by technical difficulties in identifying new bioactive peptides. Here the authors present an analytical pipeline for large-scale peptidomics applied to the rat hypothalamus, identifying thousands of endogenous neur
Externí odkaz:
https://doaj.org/article/3c5d7d3bb3cc41ce8dc8f62c4a6c9d28
Autor:
NATALIA PETERSEN, LOLA TORZ, MARINA K. GERSTENBERG, KENT PEDERSEN, SUZI H. MADSEN, SØREN ØSTERGAARD, BIRGITTE S. WULFF, SEBASTIAN B. JØRGENSEN, BIRGITTE S. ANDERSEN, BERIT Ø. CHRISTOFFERSEN, LINU M. JOHN, RUNE E. KUHRE
Publikováno v:
Diabetes. 71
Objectives: Pre-clinical evaluation of drug efficacy on weight loss is usually done in diet-induced obese (DIO) mice housed at room temperature (∼22°C) , where the mice display adaptive thermogenic responses through brown adipose tissue (BAT) acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bbb22ebf62a0ef59dedd20a33564db1
https://doi.org/10.2337/db22-232-lb
https://doi.org/10.2337/db22-232-lb
Autor:
Christian, Poulsen, Marie Østergaard, Pedersen, Per-Olof, Wahlund, Annika, Sjölander, Jens Kaalby, Thomsen, Kilian W, Conde-Frieboes, Johan F, Paulsson, Birgitte S, Wulff, Søren, Østergaard
Publikováno v:
Pharmaceutical research. 38(8)
The anorectic effect of PYYHalf-life extended PYYDeamidation of asparagine in position 18 and 29 was observed upon incubation at 37°C. Asparagine in position 18 - but not position 29 - could be substituted to glutamine without detrimental effects on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44eba2d1563d226835592aabd480e098
https://pubmed.ncbi.nlm.nih.gov/34272643
https://pubmed.ncbi.nlm.nih.gov/34272643
Autor:
Søren, Østergaard, Jacob, Kofoed, Johan F, Paulsson, Kim Grimstrup, Madsen, Rasmus, Jorgensen, Birgitte S, Wulff
Publikováno v:
Journal of medicinal chemistry. 61(23)
In recent years peptide YY (PYY) has attracted attention within the area of diabetes and obesity due to its involvement in food intake regulation and glucose homeostasis. It is well-known that PYY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdc8e9ec704caefc0f0316c99fc70760
https://pubmed.ncbi.nlm.nih.gov/30399314
https://pubmed.ncbi.nlm.nih.gov/30399314
Autor:
Bo, Xu, Silvana, Vasile, Søren, Østergaard, Johan F, Paulsson, Jasna, Pruner, Johan, Åqvist, Birgitte S, Wulff, Hugo, Gutiérrez-de-Terán, Dan, Larhammar
Publikováno v:
Molecular pharmacology. 93(4)
Understanding the agonist-receptor interactions in the neuropeptide Y (NPY)/peptide YY (PYY) signaling system is fundamental for the design of novel modulators of appetite regulation. We report here the results of a multidisciplinary approach to eluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f5061ef7669cb4f08055397137e096a
https://pubmed.ncbi.nlm.nih.gov/29367257
https://pubmed.ncbi.nlm.nih.gov/29367257