Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Birgitte P. S. Jacky"'
Autor:
Rebekah P. Dyer, Hariny M. Isoda, Gabriela S. Salcedo, Gaetano Speciale, Madison H. Fletcher, Linh Q. Le, Yi Liu, Karen Brami-Cherrier, Shiazah Z. Malik, Edwin J. Vazquez-Cintron, Andrew C. Chu, David C. Rupp, Birgitte P. S. Jacky, Thu T. M. Nguyen, Benjamin B. Katz, Lance E. Steward, Sudipta Majumdar, Amy D. Brideau-Andersen, Gregory A. Weiss
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The botulinum neurotoxin serotype A (BoNT/A) cuts a single peptide bond in SNAP25, an activity used to treat a wide range of diseases. Reengineering the substrate specificity of BoNT/A’s protease domain (LC/A) could expand its therapeutic
Externí odkaz:
https://doaj.org/article/1faa403f9c0b49ad85a29291d7a72970
Autor:
Birgitte P S Jacky, Patton E Garay, Jérôme Dupuy, Jeremy B Nelson, Brian Cai, Yanira Molina, Joanne Wang, Lance E Steward, Ron S Broide, Joseph Francis, K Roger Aoki, Raymond C Stevens, Ester Fernández-Salas
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003369 (2013)
Botulinum neurotoxin serotype A (BoNT/A) causes transient muscle paralysis by entering motor nerve terminals (MNTs) where it cleaves the SNARE protein Synaptosomal-associated protein 25 (SNAP25206) to yield SNAP25197. Cleavage of SNAP25 results in bl
Externí odkaz:
https://doaj.org/article/0af89e3fbf6f4f00b8e336144aea2833
Autor:
Thor C Møller, Volker F Wirth, Nina I Roberts, Julia Bender, Anders Bach, Birgitte P S Jacky, Kristian Strømgaard, Jan M Deussing, Thue W Schwartz, Karen L Martinez
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63352 (2013)
G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins in the human genome. Their signaling is regulated by scaffold proteins containing PDZ domains, but although these interactions are important for GPCR function, the
Externí odkaz:
https://doaj.org/article/a9defa479cb94c259cea6884cc9f692f
Autor:
Ester Fernández-Salas, Joanne Wang, Yanira Molina, Jeremy B Nelson, Birgitte P S Jacky, K Roger Aoki
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49516 (2012)
Botulinum neurotoxin serotype A (BoNT/A), a potent therapeutic used to treat various disorders, inhibits vesicular neurotransmitter exocytosis by cleaving SNAP25. Development of cell-based potency assays (CBPAs) to assess the biological function of B
Externí odkaz:
https://doaj.org/article/be97dd5401b442ad9840847343a9e930