Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Birgitte Nissen Friedrichsen"'
1
Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model
Autor: Lars Hornum, Charles R. Mackay, Claus Haase, Bodil-Cecilie Sondergaard, Søren Skov, Anneline Nansen, Chih-Chuan Chang, Renhong Tang, Birgitte Nissen Friedrichsen, Sara Marie Atkinson, Pernille A Usher
Publikováno v: Atkinson, S M, Nansen, A, Usher, P A, Sondergaard, B-C, Mackay, C R, Friedrichsen, B, Chang, C-C, Tang, R, Skov, S, Haase, C & Hornum, L 2015, ' Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model ', Autoimmunity, vol. 48, no. 7, pp. 460-470 . https://doi.org/10.3109/08916934.2015.1031888
Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarifi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513a8cac050482e5f4a6fbf464492f8c
https://pubmed.ncbi.nlm.nih.gov/25915570
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2
Stimulation of pancreatic β-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
Autor: Ying C. Lee, Jacob S. Petersen, Birgitte Nissen Friedrichsen, Vivian K Gram, Niels Blume, Jens Høiriis Nielsen, Nicole Neubauer, Annette Møldrup
Publikováno v: Journal of Endocrinology. 188:481-492
The incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), have been suggested to act as beta-cell growth factors and may therefore be of critical importance for the maintenance of a proper beta-cell ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b62a209abb0da2e6ec54e871997aead
https://doi.org/10.1677/joe.1.06160
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3
Signal Transducer and Activator of Transcription 5 Activation Is Sufficient to Drive Transcriptional Induction of Cyclin D2 Gene and Proliferation of Rat Pancreatic β-Cells
Autor: Jens Høiriis Nielsen, Christopher J. Rhodes, Birgitte Nissen Friedrichsen, Henrijette E. Richter, Nils Billestrup, Johnny A. Hansen, Annette Møldrup
Publikováno v: Molecular Endocrinology. 17:945-958
Signal transducer and activator of transcription 5 (STAT5) activation plays a central role in GH- and prolactin-mediated signal transduction in the pancreatic β-cells. In previous experiments we demonstrated that STAT5 activation is necessary for hu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e7b8ca96eb2125c9196483a4c21d18
https://doi.org/10.1210/me.2002-0356
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4
Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications
Autor: Børge Teisner, Carina Carlsson, Charlotte Harken Jensen, Birgitte K. Michelsen, Annette Møldrup, Birgitte Nissen Friedrichsen, Jens Høiriis Nielsen
Publikováno v: Friedrichsen, B N, Carlsson, C, Møldrup, A, Michelsen, B, Jensen, C H, Teisner, B & Nielsen, J H 2003, ' Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic-cells : possible physiological implications ', Journal of Endocrinology, vol. 176, no. 2, pp. 257-266 . https://doi.org/10.1677/joe.0.1760257
Preadipocyte factor-1 (Pref-1)/delta-like protein/fetal antigen-1 (FA1) is a member of the epidermal growth factor-like family. It is widely expressed in embryonic tissues, whereas in adults it is confined to the adrenal gland, the anterior pituitary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8700acd0cd84986b8a9f6c2538ac95b
https://doi.org/10.1677/joe.0.1760257
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5
Rapid-onset clinical and mechanistic effects of anti-C5aR treatment in the mouse collagen-induced arthritis model
Autor: Lars Hornum, R Tang, Bodil-Cecilie Sondergaard, Christina Andersson, Pernille A Usher, Josephine B Hebsgaard, C Chang, B Rono, Charles R. Mackay, Birgitte Nissen Friedrichsen, Carola Schellack Wenander
Publikováno v: Clinical and experimental immunology. 177(1)
Summary Preclinical evidence supports targeting the C5a receptor (C5aR) in rheumatoid arthritis (RA). To support ongoing clinical development of an anti-C5aR monoclonal antibody, we have investigated for the first time the mechanism of action and the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4d7a53e94c491fa4534c4cbc6d045d
https://pubmed.ncbi.nlm.nih.gov/24665841
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6
The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro
Autor: Ditte Tornhave, Lotte Bjerre Knudsen, Jacob S. Petersen, Birgitte Nissen Friedrichsen, Allan E. Karlsen, Søren Bregenholt, Niels Blume, Annette Møldrup
Publikováno v: Biochemical and biophysical research communications. 330(2)
We here show that GLP-1 and the long-acting GLP-1 analogue, liraglutide, interfere with diabetes-associated apoptotic processes in the beta-cell. Studies using primary neonatal rat islets showed that native GLP-1 and liraglutide inhibited both cytoki
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e692ab772cf7707b1115a2533f0af3d7
https://pubmed.ncbi.nlm.nih.gov/15796922
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7
Regulation of beta-cell mass by hormones and growth factors
Autor: Carina Carlsson, Jens Høiriis Nielsen, Birgitte Nissen Friedrichsen, Ying C. Lee, Elisabeth D. Galsgaard, Johnny A. Hansen, Annette Møldrup, Nils Billestrup
Publikováno v: Diabetes. 50
Substantial new information has accumulated on molecular mechanisms of pancreas development, regulation of beta-cell gene expression, and the role of growth factors in the differentiation, growth, and regeneration of beta-cells. The present review fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598378fd38480f3e12a28cc5a21b6f32
https://pubmed.ncbi.nlm.nih.gov/11272193
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9
Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5)
Autor: Birgitte Nissen Friedrichsen, Elisabeth D. Galsgaard, Annette Møldrup, Jens Høiriis Nielsen
Publikováno v: Molecular endocrinology (Baltimore, Md.). 15(1)
GH and PRL stimulate proliferation and insulin production of pancreatic b-cells. Whereas GH- and PRL-regulated transcription of the insulin gene in insulinoma cells has been shown to depend on STAT5 (signal transducer and activator of transcription 5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2f5135e087eb5f379f5ad9a553da27
https://pubmed.ncbi.nlm.nih.gov/11145745
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