Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Birgitte Lygren"'
Autor:
Walter Rosenthal, Kjetil Taskén, Enno Klussmann, Birgitte Lygren, Dorothea Lorenz, Katja Santamaria, Theresa McSorley, Cathrine R. Carlson, Manuela Zaccolo, Valentina Lissandron, Jessica Litzenberg, Burkhard Wiesner
Publikováno v:
EMBO reports, 8(11): 1061-1067
The beta-adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates heart rate and contractility. Here, we identified a supramolecular complex consisting of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2), its negative regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4295fa6ae4518d044fdf67165a8e1be
https://doi.org/10.1038/sj.embor.7401081
https://doi.org/10.1038/sj.embor.7401081
Publikováno v:
Biochemical Journal. 425:381-388
We recently reported that the dual-specificity AKAP (A-kinaseanchoring protein) Ezrin targets type I PKA (protein kinase A) to the vicinity of the TCR (T-cell receptor) in T-cells and, together with PAG (phosphoprotein associated with glycosphingolip
Autor:
Kjetil Taskén, Anja Ruppelt, Birgitte Lygren, Elisabeth Jarnæss, Anne Jorunn Stokka, John D. Scott
Publikováno v:
Journal of Biological Chemistry. 283:33708-33718
A-kinase anchoring proteins (AKAPs) target protein kinase A (PKA) to a variety of subcellular locations. Conventional AKAPs contain a 14-18-amino acid sequence that forms an amphipathic helix that binds with high affinity to the regulatory (R) subuni
Autor:
Birgitte Lygren, Kjetil Taskén
Publikováno v:
Expert Opinion on Biological Therapy. 8:1099-1108
The adrenaline-beta-adrenoreceptor-cAMP-protein kinase A signaling pathway regulates heart rate and contractility. Although changes in contractility are associated with cardiovascular disease, surprisingly few drugs are available that modulate the ca
Autor:
Kjetil Taskén, Pawel Dokurno, Birgitte Lygren, Matthew G. Gold, Naoto Hoshi, Cathrine Rein Carlson, John D. Scott, David Barford, George McConnachie
Publikováno v:
Molecular Cell. 24:383-395
Summary Localization of cyclic AMP (cAMP)-dependent protein kinase (PKA) by A kinase-anchoring proteins (AKAPs) restricts the action of this broad specificity kinase. The high-resolution crystal structures of the docking and dimerization (D/D) domain
Publikováno v:
Journal of Immunological Methods. 305:199-205
We describe a fast and sensitive method for isolation of detergent-resistant membranes (DRMs) from T cells by sucrose density gradient centrifugation using a smaller accumulated centrifugal force in a tabletop ultracentrifuge. Compared to previous re
Autor:
Jim Dompierre, Therese Solstad, Kjetil Taskén, Danièle Evain-Brion, Guillaume Pidoux, Pascale Gerbaud, Birgitte Lygren
Publikováno v:
Journal of Cell Science
Journal of Cell Science, 2014, 129 (Pt19), pp.4172-4185. ⟨10.1242/jcs.149609⟩
Journal of Cell Science, Company of Biologists, 2014, 129 (Pt19), pp.4172-4185. ⟨10.1242/jcs.149609⟩
Journal of Cell Science, 2014, 129 (Pt19), pp.4172-4185. ⟨10.1242/jcs.149609⟩
Journal of Cell Science, Company of Biologists, 2014, 129 (Pt19), pp.4172-4185. ⟨10.1242/jcs.149609⟩
International audience; Cell fusion occurs as part of the differentiation of some cell types, including myotubes in muscle and osteoclasts in remodeling bone. In the human placenta, mononuclear cytotrophoblasts in a human chorionic gonadotropin (hCG)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18eec7bad787124edac1cf8a5ad6b2cc
https://www.hal.inserm.fr/inserm-02556121/document
https://www.hal.inserm.fr/inserm-02556121/document
Autor:
Åsa Holmner, Ute Krengel, Julie Elisabeth Heggelund, Birgitte Lygren, Francesca Vasile, Espen Haugen, José J. Reina, Anna Bernardi, Alasdair Mackenzie
Publikováno v:
Biochemical and biophysical research communications. 418(4)
Cholera is a disease which shows a clear blood group profile, with blood group O individuals experiencing the most severe symptoms. For a long time, the cholera toxin has been suspected to be the main culprit of this blood group dependence. Here, we
Autor:
Anne N. Murphy, Amanda L. Vega, Taekjip Ha, Kjetil Taskén, Rose E. Dixon, Ankur Jain, Luis Fernando Santana, Susanna Petrosyan, John D. Scott, Christopher K. Means, Birgitte Lygren, Susan S. Taylor, Matthew G. Gold, Lorene K. Langeberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(48)
A-kinase anchoring proteins (AKAPs) tether the cAMP-dependent protein kinase (PKA) to intracellular sites where they preferentially phosphorylate target substrates. Most AKAPs exhibit nanomolar affinity for the regulatory (RII) subunit of the type II
Publikováno v:
The Biochemical journal. 424(1)
We have reported previously the design of a RIAD (RI-anchoring disruptor) peptide that specifically displaces PKA (protein kinase A) type I from the AKAP (A-kinase-anchoring protein) ezrin, which is present in the immunological synapse of T-cells. Th