Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Birgitte K. Michelsen"'
Publikováno v:
European Journal of Immunology. 35:2583-2590
Type 1 diabetes (T1D) is an autoimmune disease in which the pancreatic beta-cells are destroyed in an immune-mediated process. In one mouse model of T1D, the co-expression of the costimulatory molecule, B7-1, and the pro-inflammatory cytokine, tumor
Publikováno v:
Diabetes. 53:2588-2595
The initial events leading to activation of the immune system in type 1 diabetes are still largely unknown. In vivo, dendritic cells (DCs) are thought to be the only antigen-presenting cells (APCs) capable of activating naïve T-cells and are theref
Autor:
Dominic Picarella, Sylvie Guerder, Birgitte K. Michelsen, Richard A. Flavell, Nina Brenden, Kresten Skak
Publikováno v:
European Journal of Immunology. 33:1341-1350
Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro-inflammatory and protective cytokines that is poorly understood. We have here addressed how the local expression of the inflammato
Autor:
Birgitte K. Michelsen, Niels Ødum, Klaus Rieneck, Søren Tomra, Lone Frier Bovin, Søren Skov, Kresten Skak
Publikováno v:
Blood. 101:1430-1438
Here we report that histone deacetylase inhibitors (HDAC-i) comprise a new class of immunosuppressive agents. HDAC-i inhibited CD4 T-cell proliferation in a dose-dependent manner, which was not caused by apoptosis or decreased viability. Although ear
Autor:
Børge Teisner, Carina Carlsson, Charlotte Harken Jensen, Birgitte K. Michelsen, Annette Møldrup, Birgitte Nissen Friedrichsen, Jens Høiriis Nielsen
Publikováno v:
Friedrichsen, B N, Carlsson, C, Møldrup, A, Michelsen, B, Jensen, C H, Teisner, B & Nielsen, J H 2003, ' Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic-cells : possible physiological implications ', Journal of Endocrinology, vol. 176, no. 2, pp. 257-266 . https://doi.org/10.1677/joe.0.1760257
Preadipocyte factor-1 (Pref-1)/delta-like protein/fetal antigen-1 (FA1) is a member of the epidermal growth factor-like family. It is widely expressed in embryonic tissues, whereas in adults it is confined to the adrenal gland, the anterior pituitary
Publikováno v:
Immunology. 107:489-499
In order to avoid autoimmunity and excessive tissue destruction, the action of certain immunoinhibitory substances are very important for negative regulation of the immune system. Interleukin-10 (IL-10) is an important immunoregulatory cytokine which
Publikováno v:
Scandinavian Journal of Immunology. 56:492-503
Antigen-presenting cells (APCs) are crucial for the generation of a functional immune response to pathogens. Furthermore, there is abundant evidence for their importance in primary T-cell activation, B-cell maturation and maintenance of an ongoing im
Publikováno v:
DNA Sequence. 11:485-499
GAD65 and GAD67 are two isoforms of the enzyme glutamic acid decarboxylase which catalyze the production of GABA from glutamate, primarily in the brain. However, GAD and GABA also prevail in the retina, testes and islets of Langerhans. The main funct
Autor:
Bryan Coon, S Seewaldt, Urs Christen, Mette Ejrnaes, Birgitte K. Michelsen, Helen E. Thomas, Tom Wolfe, M. G. Von Herrath, Thomas W.H. Kay, Evelyn Rodrigo
Publikováno v:
Diabetes. 49:1801-1809
Autoimmune diabetes is caused by selective loss of insulin-producing pancreatic beta-cells. The main factors directly implicated in beta-cell death are autoreactive, cytotoxic (islet-antigen specific) T-lymphocytes (CTL), and inflammatory cytokines.
Autor:
Anne Worsaae, Annette Plesner, Thomas Dyrberg, Birgitte K. Michelsen, Carsten F. Gotfredsen, Jacob S. Petersen
Publikováno v:
Journal of Autoimmunity. 11:335-341
Glutamic acid decarboxylase autoimmunity was investigated by immunizing female BALB/c, C57B1/6, National Marine Research Institute (NMRI) and non-obese diabetic (NOD) mice once or twice with glumatic acid decarboxylase, GAD65, bovine serum albumin, o