Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Birgitta R Knudsen"'
Autor:
Amit Roy, Cinzia Tesauro, Rikke Frøhlich, Marianne S Hede, Maria J Nielsen, Eigil Kjeldsen, Bjarne Bonven, Magnus Stougaard, Irina Gromova, Birgitta R Knudsen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99628 (2014)
The CD44+ and CD44- subpopulations of the colorectal cancer cell line Caco2 were analyzed separately for their sensitivities to the antitumor drug camptothecin. CD44+ cells were less sensitive to camptothecin than CD44- cells. The relative resistance
Externí odkaz:
https://doaj.org/article/766ddafd11cc4af1bc4fb673e4fd74c0
Autor:
Victoria Marini, Fedor Nikulenkov, Pounami Samadder, Sissel Juul, Birgitta R. Knudsen, Lumir Krejci
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background DNA-protein cross-links (DPCs) are one of the most deleterious DNA lesions, originating from various sources, including enzymatic activity. For instance, topoisomerases, which play a fundamental role in DNA metabolic processes suc
Externí odkaz:
https://doaj.org/article/f27960dd49134ebbb90288484d64163e
Autor:
Trine Juul-Kristensen, Josephine Geertsen Keller, Kathrine Nygaard Borg, Noriko Y. Hansen, Amalie Foldager, Rasmus Ladegaard, Yi-Ping Ho, Volker Loeschcke, Birgitta R. Knudsen
Publikováno v:
Biosensors, Vol 13, Iss 11, p 950 (2023)
In the modern world with climate changes and increasing pollution, different types of stress are becoming an increasing challenge. Hence, the identification of reliable biomarkers of stress and accessible sensors to measure such biomarkers are attrac
Externí odkaz:
https://doaj.org/article/65620ff904324773b6aadae86a7d5fc8
Autor:
Josephine Geertsen Keller, Kamilla Vandsø Petersen, Karol Mizielinski, Celine Thiesen, Lotte Bjergbæk, Rosa M. Reguera, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Angela Trejo, Carme Masdeu, Concepcion Alonso, Birgitta R. Knudsen, Cinzia Tesauro
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 657 (2023)
With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary. Among these biomarkers are DNA topoisomerases, which are key en
Externí odkaz:
https://doaj.org/article/fd2e9d00fa1443c6b4c2c8d52abb1f5f
Autor:
Cinzia Tesauro, Anne Katrine Simonsen, Marie Bech Andersen, Kamilla Wandsoe Petersen, Emil Laust Kristoffersen, Line Algreen, Noriko Yokoyama Hansen, Anne Bech Andersen, Ann Katrine Jakobsen, Magnus Stougaard, Pavel Gromov, Birgitta R. Knudsen, Irina Gromova
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Camptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TOP1) to a cell poison
Externí odkaz:
https://doaj.org/article/5bdd00634203464bab2f0dbccd74d249
Autor:
Kamilla Vandsø Petersen, Cinzia Tesauro, Marianne Smedegaard Hede, Camilla Pages, Lærke Bay Marcussen, Josephine Geertsen Keller, Magnus Bugge, Kasper Holm, Lotte Bjergbæk, Magnus Stougaard, Christian Wejse, Birgitta R. Knudsen
Publikováno v:
Sensors, Vol 22, Iss 20, p 7763 (2022)
Restriction endonucleases are expressed in all bacteria investigated so far and play an essential role for the bacterial defense against viral infections. Besides their important biological role, restriction endonucleases are of great use for differe
Externí odkaz:
https://doaj.org/article/edc25d98584046099e9443a126c573bb
Autor:
Sarah K. Schröder, Herdit M. Schüler, Kamilla V. Petersen, Cinzia Tesauro, Birgitta R. Knudsen, Finn S. Pedersen, Frederike Krus, Eva M. Buhl, Elke Roeb, Martin Roderfeld, Radovan Borojevic, Jamie L. Almeida, Ralf Weiskirchen
Publikováno v:
Cells, Vol 11, Iss 9, p 1504 (2022)
The murine cell line GRX has been introduced as an experimental tool to study aspects of hepatic stellate cell biology. It was established from livers of C3H/HeN mice that were infected with cercariae of Schistosoma mansoni. Although these cells disp
Externí odkaz:
https://doaj.org/article/6b4c8b57c3ad48d0b3d5560c94c34f5d
Autor:
Asier Selas, María Fuertes, Estela Melcón-Fernández, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Birgitta R. Knudsen, Francisco Palacios, Concepcion Alonso
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 784 (2021)
This work describes, for the first time, the synthesis of dialkyl (2-arylquinolin-8-yl)phosphonate derivatives. The preparation was carried out through a direct and simple process as a multicomponent Povarov reaction of aminophenylphosphonates, aldeh
Externí odkaz:
https://doaj.org/article/7eb147c846744909bf8b44a6f38af294
Autor:
Cinzia Tesauro, Birgitta R. Knudsen, Magnus Stougaard, Kamilla Vandsø Petersen, Karol Mizielinski, Josephine Geertsen Keller
Publikováno v:
Keller, J G, Mizielinski, K, Petersen, K V, Stougaard, M, Knudsen, B R & Tesauro, C 2022, ' Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples ', Journal of visualized experiments : JoVE, vol. 190, e64484 . https://doi.org/10.3791/64484
Isothermal amplification-based techniques such as the rolling circle amplification have been successfully employed for the detection of nucleic acids, protein amounts, or other relevant molecules. These methods have shown to be substantial alternativ
Autor:
Josephine Geertsen Keller, Kirstine Mejlstrup Hymøller, Maria Eriksen Thorsager, Noriko Y Hansen, Jens Uldum Erlandsen, Cinzia Tesauro, Anne Katrine W Simonsen, Anne Bech Andersen, Kamilla Vandsø Petersen, Lise Lolle Holm, Magnus Stougaard, Brage Storstein Andresen, Peter Kristensen, Rikke Frøhlich, Birgitta R Knudsen
Publikováno v:
Keller, J G, Hymøller, K M, Thorsager, M E, Hansen, N Y, Erlandsen, J U, Tesauro, C, Simonsen, A K W, Andersen, A B, VandsøPetersen, K, Holm, L L, Stougaard, M, Andresen, B S, Kristensen, P, Frøhlich, R & Knudsen, B R 2022, ' Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation ', Nucleic Acids Research, vol. 50, no. 11, pp. 6332-6342 . https://doi.org/10.1093/nar/gkac482
Keller, J G, Hymøller, K M, Thorsager, M E, Hansen, N Y, Erlandsen, J U, Tesauro, C, Simonsen, A K W, Andersen, A B, Vandsø Petersen, K, Holm, L L, Stougaard, M, Andresen, B S, Kristensen, P, Frøhlich, R & Knudsen, B R 2022, ' Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation ', Nucleic Acids Research, vol. 50, no. 11, pp. 6332-6342 . https://doi.org/10.1093/nar/gkac482
Keller, J G, Hymøller, K M, Thorsager, M E, Hansen, N Y, Erlandsen, J U, Tesauro, C, Simonsen, A K W, Andersen, A B, Vandsø Petersen, K, Holm, L L, Stougaard, M, Andresen, B S, Kristensen, P, Frøhlich, R & Knudsen, B R 2022, ' Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation ', Nucleic Acids Research, vol. 50, no. 11, pp. 6332-6342 . https://doi.org/10.1093/nar/gkac482
We have investigated the function of human topoisomerase 1 (TOP1) in regulation of G-quadruplex (G4) formation in the Pu27 region of the MYC P1 promoter. Pu27 is among the best characterized G4 forming sequences in the human genome and it is well kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606b4feca49e6ce6db36ead898879b1b
https://vbn.aau.dk/da/publications/547d3b84-5a5b-4882-947d-67ad863246d1
https://vbn.aau.dk/da/publications/547d3b84-5a5b-4882-947d-67ad863246d1