An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China

Autor: Xinyi Yang, Congran Li, Xiukun Wang, Zhonghui Zheng, Peiyi Sun, Chunjie Xu, Luni Chen, Jiandong Jiang, Staffan Normark, Birgitta Henriques-Normark, Xuefu You

Publikováno v: Engineering, Vol 38, Iss , Pp 52-68 (2024)

Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries. In this context, one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed. Although

Externí odkaz: https://doaj.org/article/efd940f3eba44a6fa60aefb262ea8f1d

Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium

Autor: David Shaw, MBBCh, Raquel Abad, PhD, Zahin Amin-Chowdhury, MSc, Adriana Bautista, MSc, Desiree Bennett, PhD, Karen Broughton, MSc, Bin Cao, ProfMD, Carlo Casanova, PhD, Eun Hwa Choi, ProfMD, Yiu-Wai Chu, PhD, Heike Claus, PhD, Juliana Coelho, PhD, Mary Corcoran, PhD, Simon Cottrell, PhD, Robert Cunney, MB, Lize Cuypers, PhD, Tine Dalby, PhD, Heather Davies, NZCS, Linda de Gouveia, NatDipMedTech, Ala-Eddine Deghmane, PhD, Walter Demczuk, BSc, Stefanie Desmet, PhD, Mirian Domenech, PhD, Richard Drew, MD, Mignon du Plessis, PhD, Carolina Duarte, PhD, Helga Erlendsdóttir, ProfMSc, Norman K Fry, PhD, Kurt Fuursted, MD, Thomas Hale, ProfPhD, Desiree Henares, PhD, Birgitta Henriques-Normark, ProfMD, Markus Hilty, PhD, Steen Hoffmann, MD, Hilary Humphreys, ProfMD, Margaret Ip, ProfMSc, Susanne Jacobsson, PhD, Christopher Johnson, PhD, Jillian Johnston, MBBS, Keith A Jolley, PhD, Aníbal Kawabata, Jana Kozakova, MD, Karl G Kristinsson, ProfMD, Pavla Krizova, MD, Alicja Kuch, PhD, Shamez Ladhani, MD, Thiên-Trí Lâm, MD, María Eugenia León, MSc, Laura Lindholm, MSc, David Litt, PhD, Martin C J Maiden, ProfPhD, Irene Martin, BSc, Delphine Martiny, ProfPhD, Wesley Mattheus, PhD, Noel D McCarthy, ProfDPhil, Mary Meehan, PhD, Susan Meiring, MBChB, Paula Mölling, PhD, Eva Morfeldt, PhD, Julie Morgan, HND, Robert Mulhall, PhD, Carmen Muñoz-Almagro, ProfMD, David Murdoch, ProfMD, Joy Murphy, BA Hons, Martin Musilek, PhD, Alexandre Mzabi, MD, Ludmila Novakova, MSc, Shahin Oftadeh, PhD, Amaresh Perez-Argüello, MLT, Maria Pérez-Vázquez, PhD, Monique Perrin, MD, Malorie Perry, MSc, Benoit Prevost, PhD, Maria Roberts, BSc(Hons), Assaf Rokney, PhD, Merav Ron, PhD, Olga Marina Sanabria, MPH, Kevin J Scott, PhD, Carmen Sheppard, PhD, Lotta Siira, PhD, Vitali Sintchenko, ProfPhD, Anna Skoczyńska, ProfPhD, Monica Sloan, Hans-Christian Slotved, DMSc, Andrew J Smith, ProfFRCPath, Anneke Steens, PhD, Muhamed-Kheir Taha, ProfMD, Maija Toropainen, PhD, Georgina Tzanakaki, ProfPhD, Anni Vainio, PhD, Mark P G van der Linden, PhD, Nina M van Sorge, ProfPhD, Emmanuelle Varon, MD, Sandra Vohrnova, MD, Anne von Gottberg, ProfPhD, Jose Yuste, PhD, Rosemeire Zanella, PhD, Fei Zhou, PhD, Angela B Brueggemann, ProfDPhil

Publikováno v: The Lancet: Digital Health, Vol 5, Iss 9, Pp e582-e593 (2023)

Summary: Background: The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitid

Externí odkaz: https://doaj.org/article/384c876404e140c8b5a86eec7ad5243e

Mannose receptor‐derived peptides neutralize pore‐forming toxins and reduce inflammation and development of pneumococcal disease

Autor: Karthik Subramanian, Federico Iovino, Vasiliki Tsikourkitoudi, Padryk Merkl, Sultan Ahmed, Samuel B Berry, Marie‐Stephanie Aschtgen, Mattias Svensson, Peter Bergman, Georgios A Sotiriou, Birgitta Henriques‐Normark

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-17 (2020)

Abstract Cholesterol‐dependent cytolysins (CDCs) are essential virulence factors for many human pathogens like Streptococcus pneumoniae (pneumolysin, PLY), Streptococcus pyogenes (streptolysin O, SLO), and Listeria monocytogenes (Listeriolysin, LLO

Externí odkaz: https://doaj.org/article/9ff4d456d5594dcc94df8d7eff0cd162

Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data

Autor: Angela B Brueggemann, ProfDPhil, Melissa J Jansen van Rensburg, ProfDPhil, David Shaw, MD, Noel D McCarthy, ProfDPhil, Keith A Jolley, PhD, Martin C J Maiden, ProfPhD, Mark P G van der Linden, PhD, Zahin Amin-Chowdhury, BSc, Désirée E Bennett, PhD, Ray Borrow, PhD, Maria-Cristina C Brandileone, PhD, Karen Broughton, MSc, Ruth Campbell, Bin Cao, ProfMD, Carlo Casanova, PhD, Eun Hwa Choi, ProfMD, Yiu Wai Chu, PhD, Stephen A Clark, PhD, Heike Claus, PhD, Juliana Coelho, PhD, Mary Corcoran, PhD, Simon Cottrell, PhD, Robert J Cunney, MD, Tine Dalby, PhD, Heather Davies, NZCS, Linda de Gouveia, NatDipMicro, Ala-Eddine Deghmane, PhD, Walter Demczuk, BSc, Stefanie Desmet, PharmD, Richard J Drew, MD, Mignon du Plessis, PhD, Helga Erlendsdottir, ProfMSc, Norman K Fry, PhD, Kurt Fuursted, MD, Steve J Gray, PhD, Birgitta Henriques-Normark, ProfMD, Thomas Hale, PhD, Markus Hilty, PhD, Steen Hoffmann, MD, Hilary Humphreys, ProfMD, Margaret Ip, MD, Susanne Jacobsson, PhD, Jillian Johnston, MBBS, Jana Kozakova, MD, Karl G Kristinsson, ProfMD, Pavla Krizova, MD, Alicja Kuch, PhD, Shamez N Ladhani, MD, Thiên-Trí Lâm, MD, Vera Lebedova, MD, Laura Lindholm, MSc, David J Litt, PhD, Irene Martin, BSc, Delphine Martiny, ProfPhD, Wesley Mattheus, PhD, Martha McElligott, PhD, Mary Meehan, PhD, Susan Meiring, MBChB, Paula Mölling, PhD, Eva Morfeldt, PhD, Julie Morgan, HND, Robert M Mulhall, PhD, Carmen Muñoz-Almagro, ProfMD, David R Murdoch, ProfMD, Joy Murphy, BA Hons, Martin Musilek, PhD, Alexandre Mzabi, MD, Amaresh Perez-Argüello, MLT, Monique Perrin, MD, Malorie Perry, MSc, Alba Redin, BSc, Richard Roberts, MPH, Maria Roberts, BSc, Assaf Rokney, PhD, Merav Ron, PhD, Kevin J Scott, PhD, Carmen L Sheppard, PhD, Lotta Siira, PhD, Anna Skoczyńska, ProfPhD, Monica Sloan, Hans-Christian Slotved, PhD, Andrew J Smith, ProfPhD, Joon Young Song, MD, Muhamed-Kheir Taha, MD, Maija Toropainen, PhD, Dominic Tsang, MD, Anni Vainio, PhD, Nina M van Sorge, PhD, Emmanuelle Varon, MD, Jiri Vlach, PhD, Ulrich Vogel, ProfMD, Sandra Vohrnova, MD, Anne von Gottberg, PhD, Rosemeire C Zanella, PhD, Fei Zhou, PhD

Publikováno v: The Lancet: Digital Health, Vol 3, Iss 6, Pp e360-e370 (2021)

Summary: Background: Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, which are typically transmitted via respiratory droplets, are leading causes of invasive diseases, including bacteraemic pneumonia and meningitis, and

Externí odkaz: https://doaj.org/article/f6fe24685f384a75a4df9fa551875158

Serotype and molecular diversity of nasopharyngeal Streptococcus pneumoniae isolates from children before and after vaccination with the ten-valent pneumococcal conjugate vaccine (PCV10) in Ethiopia

Autor: Wondewosen Tsegaye Sime, Abraham Aseffa, Yimtubezenash Woldeamanuel, Sarah Brovall, Eva Morfeldt, Birgitta Henriques-Normark

Publikováno v: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-11 (2019)

Abstract Background Streptococcus pneumoniae is a major human pathogen, and nasopharyngeal colonization is the first step for transmission and pathogenesis of pneumococcal diseases. Ethiopia introduced the 10-valent pneumococcal conjugate vaccine (PC

Externí odkaz: https://doaj.org/article/3d294c461ab24452a6c3305720c90a5c