Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Birgit Wobith"'
Autor:
Birgit Wobith, Svetlana Schulz, Evgenia V. Nurieva, Olga N. Zefirova, N. A. Zefirov, Sergei A. Kuznetsov
Publikováno v:
Pure and Applied Chemistry. 92:1217-1226
Colchicine derivative bearing substituted bispidine moiety, namely N-{7-(3,7-Di-(tert-butoxycarbonyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-yl)-oxy-7-oxoheptanoyl}-N-deacetylcolchicine, was synthesized and tested for its effect on the net of mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc0e20e62f5cac0c191f0fc27dba784
https://doi.org/10.1515/pac-2019-1215
https://doi.org/10.1515/pac-2019-1215
Autor:
Sergey A. Kuznetsov, Natalia A. Maximova, N. A. Zefirov, N. A. Lozinskaya, Birgit Wobith, Marina V. Proskurnina, Elena V. Kharitonashvili, Daniil R. Bazanov, Olga N. Zefirova, S. E. Sosonyuk
Publikováno v:
Mendeleev Communications. 30:7-9
To overcome the metabolic instability of anticancer agent 2-methoxyestradiol, two its dichloroacetylated prodrugs and three new control compounds have been synthesized and evaluated in different in vitro assays with cancer cells A549 and MCF-7. Both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0a7fff5199ed80def2e459ef6fc9dd8
https://doi.org/10.1016/j.mencom.2020.01.002
https://doi.org/10.1016/j.mencom.2020.01.002
Publikováno v:
Structural Chemistry. 30:465-471
Four novel conjugates of adamantane connected at a bridgehead position via four-bond linker to structurally different ligands interacting with colchicine binding site of tubulin were synthesized. All compounds were found to inhibit cancer cell prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439fe8f46bec70e17a132a74205c14ed
https://doi.org/10.1007/s11224-018-1219-9
https://doi.org/10.1007/s11224-018-1219-9
Autor:
Birgit Wobith, Syed Riyaz, Ch. Venkata Ramana Reddy, Evgenia V. Nurieva, Olga N. Zefirova, N. A. Zefirov, Ann Kruth, Sergei A. Kuznetsov
Publikováno v:
Mendeleev Communications. 28:475-478
New podophyllotoxin C4-derivatives with bridged and cage moieties were synthesized by the Steglich esterification of podophyllotoxin with polycyclic carboxylic acids or by etherication with (adamantan-1-yl)methanol in the presence of BF3·Et2O with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9aea92d8cefe7e9fe59e4edd687de34
https://doi.org/10.1016/j.mencom.2018.09.007
https://doi.org/10.1016/j.mencom.2018.09.007
Autor:
Birgit Wobith, A. V. Mamaeva, Olga N. Zefirova, E. V. Nurieva, N. A. Zefirov, Sergei A. Kuznetsov
Publikováno v:
Russian Chemical Bulletin. 67:688-693
Synthesis of analogs of tubuloclustin (N-(7-adamant-2-yloxy-7-oxoheptanoyl)-N-deacetylcolchicine (1)) with the colchicine fragment replaced with 2-methoxyestradiol scaffold attached via phenolic hydroxy group was described. Esters 3a–c exhibit mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90c7f678d88aff46b9c489466c79dbb
https://doi.org/10.1007/s11172-018-2123-6
https://doi.org/10.1007/s11172-018-2123-6
Autor:
N. A. Zefirov, Olga N. Zefirova, Yu. A. Pikulina, Birgit Wobith, S. A. Kuznetsov, A. V. Ogon´kov, E. V. Nurieva
Publikováno v:
Russian Chemical Bulletin. 66:1503-1509
Adamantaneacetic and adamantanecarboxylic acid esters containing 3-hydroxy-4-methoxybenzyl, 3,4,5-trimethoxybenzyl, or 5-(hydroxymethyl)-2-methoxyphenyl groups were synthesized as unusual analogs of natural antitumor and anti-tubulin agents combretas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a822c5a835b6d4cbc261dc1185e43b6f
https://doi.org/10.1007/s11172-017-1915-4
https://doi.org/10.1007/s11172-017-1915-4
Autor:
Elena S. Barskaia, N. A. Zefirov, Alexander G. Majouga, Sergei A. Kuznetsov, Birgit Wobith, Olga N. Zefirova, Elena K. Beloglazkina, Nikolay V. Zyk, A. A. Beloglazkina
Publikováno v:
Medicinal Chemistry Research. 25:1239-1249
Compounds interacting with cell protein tubulin and microtubules represent an important type of antimitotic agents. A series of tubulin-targeted 2-aryl-4-benzoyl-imidazoles were reported to possess high cytotoxicity, and so, we prepared a series of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6207c5264a7c9ce55ced761993175a91
https://doi.org/10.1007/s00044-016-1566-2
https://doi.org/10.1007/s00044-016-1566-2
Autor:
Elena B. Averina, Tamara S. Kuznetsova, N. A. Zefirov, Olga N. Zefirova, Nikolay S. Zefirov, Victor B. Rybakov, Yuri K. Grishin, Dmitry A. Vasilenko, Birgit Wobith, Sergei A. Kuznetsov
Publikováno v:
Mendeleev Communications. 27:228-230
5-Aminoisoxazoles containing trimethoxy- and methylenedioxyphenyl moieties were prepared by heterocyclization of electrophilic alkenes with tetranitromethane in the presence of triethylamine with subsequent reduction of resulting 5-nitroisoxazoles. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98f58a85cd34a86115d7c39684234e9c
https://doi.org/10.1016/j.mencom.2017.05.003
https://doi.org/10.1016/j.mencom.2017.05.003
Autor:
E. S. Barskaia, N. A. Zefirov, A. A. Beloglazkina, A. G. Majouga, Sergei A. Kuznetsov, Nikolai V. Zyk, Elena K. Beloglazkina, Birgit Wobith, Olga N. Zefirova
Publikováno v:
Russian Chemical Bulletin. 64:1560-1563
A series of 2-aryl-5-arylmethylidene-1,3-oxazol-5(4H)-ones and 2-aryl-5-arylmethylidene-N-methyl-3,5-dihydro-4H-imidazol-4-ones was synthesized as structural analogs of combret- astatin A-4 (a compound possessing antitumor activity). (5Z)-5-[(4-Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78c0ea291fd603f46f67392a4f7c9650
https://doi.org/10.1007/s11172-015-1041-0
https://doi.org/10.1007/s11172-015-1041-0
Autor:
E. V. Nurieva, Olga N. Zefirova, Birgit Wobith, A. V. Mamaeva, E. M. Treshchalina, N. A. Lesnaya, V. I. Romanenko, Sergei A. Kuznetsov, Ya. S. Glazkova, N. A. Zefirov
Publikováno v:
Pharmaceutical Chemistry Journal. 48:373-378
Daily administration of tubuloclustin (1 mg/kg, 5 d, i.p.) to BDF1 mice with i.p. transplanted P388 leukemia extended statistically significantly by 45% their life spans compared with those of untreated controls (17 vs. 11.7 ± 3 d). The possibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d7ffb7a319e1759540db5b9d95379c
https://doi.org/10.1007/s11094-014-1113-8
https://doi.org/10.1007/s11094-014-1113-8