Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Birgit Vogler"'
Autor:
Nicola Benedicter, Karl Messlinger, Birgit Vogler, Kimberly D. Mackenzie, Jennifer Stratton, Nadine Friedrich, Mária Dux
Publikováno v:
Neurology International, Vol 15, Iss 2, Pp 622-637 (2023)
Migraine pain is frequently accompanied by cranial hyperalgesia and allodynia. Calcitonin gene-related peptide (CGRP) is implicated in migraine pathophysiology but its role in facial hypersensitivity is not entirely clear. In this study, we investiga
Externí odkaz:
https://doaj.org/article/110e2c9230c44f9785e7fc996db02cb2
Autor:
Nicola Benedicter, Birgit Vogler, Annette Kuhn, Jana Schramm, Kimberly D. Mackenzie, Jennifer Stratton, Mária Dux, Karl Messlinger
Publikováno v:
Cells, Vol 13, Iss 7, p 572 (2024)
Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) have been recognized as important mediators in migraine but their mechanisms of action and interaction have not been fully elucidated. Monoclonal anti-CGRP antibodies like fremanezumab are
Externí odkaz:
https://doaj.org/article/35d813fc18a14de7914939d7292fc780
Autor:
Birgit Vogler, Annette Kuhn, Kimberly D. Mackenzie, Jennifer Stratton, Mária Dux, Karl Messlinger
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13471 (2023)
Treatment with the anti-CGRP antibody fremanezumab is successful in the prevention of chronic and frequent episodic migraine. In preclinical rat experiments, fremanezumab has been shown to reduce calcitonin gene-related peptide (CGRP) release from tr
Externí odkaz:
https://doaj.org/article/a1ea3b8bf19d4d70ba4a1c5aa148042f
Publikováno v:
The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Calcitonin gene-related peptide (CGRP) is released from activated meningeal afferent fibres in the cranial dura mater, which likely accompanies severe headache attacks. Increased CGRP levels have been observed in different extrace
Externí odkaz:
https://doaj.org/article/3d4f9b39b93e458b83522e46bfded3cf
Publikováno v:
The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. Calcitonin gene-related peptide (CGRP
Externí odkaz:
https://doaj.org/article/b853d0e6065d47349a751c79f7e02132
The Anti-CGRP Antibody Fremanezumab Lowers CGRP Release from Rat Dura Mater and Meningeal Blood Flow
Autor:
Mária Dux, Birgit Vogler, Annette Kuhn, Kimberly D. Mackenzie, Jennifer Stratton, Karl Messlinger
Publikováno v:
Cells, Vol 11, Iss 11, p 1768 (2022)
Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) belong to a new generation of therapeutics that are effective in the prevention of migraine. CGRP, a potent vasodilator, is strongly implicated in the path
Externí odkaz:
https://doaj.org/article/e1dfe848cec743819eb2c7e06a066679
Autor:
Annette Kuhn, Florian Frank, Julika Sertel-Nakajima, Karl Messlinger, Birgit Vogler, Gregor Broessner
Publikováno v:
Cephalalgia
Background Calcitonin gene-related peptide plasma levels have frequently been determined as a biomarker for primary headaches. However, published data is often inconsistent resulting from different methods that are not precisely described in most stu
Autor:
Julika Sertel-Nakajima, Jana Schramm, Alexandru Babes, Birgit Vogler, Karl Messlinger, Jessica Manchen, Mária Dux
Background The α1 -adrenoceptor agonist, phenylephrine, is used at high concentrations as a mydriatic agent and for the treatment of nasal congestion. Among its adverse side-effects transient burning sensations are reported indicating activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbe4f67555b4ab02b0f045eb3c94198
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/14669
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/14669
Publikováno v:
British Journal of Pharmacology. 173:431-445
Background and purpose Meningeal blood flow is controlled by CGRP released from trigeminal afferents and NO mainly produced in arterial endothelium. The vasodilator effect of NO may be due to the NO-derived compound, nitroxyl (HNO), generated through
Publikováno v:
European journal of pain (London, England). 21(5)
Background The TRP channel ankyrin type 1 (TRPA1) is a nonselective cation channel known to be activated by environmental irritants, cold and endogenous mediators of inflammation. Activation of TRPA1 in trigeminal afferents innervating meningeal stru