Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Autor: David Vehlow, Jeremy P. H. Wong, Birgit Urban, Janek Weißpflog, Annett Gebert, Matthias Schumacher, Michael Gelinsky, Manfred Stamm, Martin Müller

Publikováno v: Pharmaceutics, Vol 12, Iss 9, p 799 (2020)

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of p

Externí odkaz: https://doaj.org/article/2c787cb28ea143439c70aa275ed22fd0

β-Sheet Structure Formation within Binary Blends of Two Spider Silk Related Peptides

Autor: Mirjam Hofmaier, Mikhail Malanin, Eva Bittrich, Sarah Lentz, Birgit Urban, Thomas Scheibel, Andreas Fery, Martin Müller

Publikováno v: Biomacromolecules. 24:825-840

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4353d5ccaa1f5665938af5c3164a404
https://doi.org/10.1021/acs.biomac.2c01266

Dichroic Fourier Transform Infrared Spectroscopy Characterization of the β-Sheet Orientation in Spider Silk Films on Silicon Substrates

Autor: Andreas Fery, Sarah Lentz, Mirjam Hofmaier, Martin Müller, Thomas Scheibel, Christian B. Borkner, Birgit Urban

Publikováno v: The journal of physical chemistry. B. 125(4)

Orientation analysis of the β-sheet structure within films of the established recombinant spider silk protein eADF4(C16) was performed using a concept based on dichroic transmission- and attenuated total reflection-Fourier transform infrared spectro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cacd85f2ffcaffbc83ef5757d113fb7
https://pubmed.ncbi.nlm.nih.gov/33433229

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Autor: Jeremy P H Wong, David Vehlow, Michael Gelinsky, Annett Gebert, Matthias Schumacher, Martin Müller, Birgit Urban, Manfred Stamm, Janek Weißpflog

Publikováno v: Pharmaceutics, Vol 12, Iss 799, p 799 (2020)
Pharmaceutics, 12(9):799. Multidisciplinary Digital Publishing Institute (MDPI)
Pharmaceutics
Volume 12
Issue 9

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f32c9b65e2b60f7b013dcb8d1f6823
https://doi.org/10.3390/pharmaceutics12090799

Adjusting and switching the elution of bone therapeutics from thermoaddressable coatings of poly(N-isopropylacrylamide-co-acrylic acid)/ethylenediaminocellulose complex particles

Autor: David Vehlow, Martin Müller, M.L. Möller, Birgit Urban

Publikováno v: Colloid and Polymer Science. 295:1187-1199

Thermoaddressable coatings based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-AA) complexed with ethylenediamine-modified cellulose (EDAC) are reported eluting bone therapeutic zoledronate (ZOL) in defined amounts. At T = 25 °C, phase-sepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d5cf21e35ce04177b1fbb98248c2315
https://doi.org/10.1007/s00396-017-4112-y