Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Birgit T. Priest"'
Publikováno v:
eLife, Vol 6 (2017)
Available evidence indicates voltage-gated Na+ channels (VGSCs) in peripheral sensory neurons are essential for the pain and hypersensitivity associated with tissue injury. However, our understanding of the biophysical and pharmacological properties
Externí odkaz:
https://doaj.org/article/058795cc240841c8a0b782d4b34436e8
Autor:
Birgit T Priest, Gul eErdemli
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Externí odkaz:
https://doaj.org/article/265fa8e9ec4048b899482a6e0593c4a1
Autor:
Birgit T. Priest, Alexander Pasternak
Publikováno v:
Future Medicinal Chemistry. 9:1963-1977
Kir1.1 (renal outer medullary K+) channels are potassium channels expressed almost exclusively in the kidney and play a role in the body's electrolyte and water balance. Potassium efflux through Kir1.1 compliments the role of transporters and sodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b576441862bbd8e20ab4b54fe45e9db
https://doi.org/10.4155/fmc-2017-0083
https://doi.org/10.4155/fmc-2017-0083
Autor:
Haifeng Tang, Zack Zhiqiang Guo, Lee-Yuh Pai, Adam B. Weinglass, Xin Gu, Shuzhi Dong, Alexander Pasternak, Yang Yu, Kathleen A. Sullivan, Mengwei Hu, Kelsey VanGelder, Gloria J. Zingaro, Sophie Roy, Jessica Liu, Qinghong Fu, Birgit T. Priest, Michael Margulis, Brande Thomas-Fowlkes, Pierre Morissette, Robin E. Haimbach, Zhicai Wu, Juliann Ehrhart, Karen Owens, Caryn Hampton, Zhi-Cai Shi, Jessica Frie, Ron Ferguson, Shiyao Xu, Vincent Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2559-2566
SAR in the previously described spirocyclic ROMK inhibitor series was further evolved from lead 4 by modification of the spirocyclic core and identification of novel right-side pharmacophores. In this process, it was discovered that the spiropyrrolid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2dc6104dc29c3168c501b413896773
https://doi.org/10.1016/j.bmcl.2017.03.086
https://doi.org/10.1016/j.bmcl.2017.03.086
Autor:
Lee-Yuh Pai, Aaron Corona, Harry R. Chobanian, John P. Felix, Matthew J. Clements, Karen Owens, Haifeng Tang, Brande Thomas-Fowlkes, Kathleen A. Sullivan, Alexander Pasternak, Caryn Hampton, Jessica Frie, Vincent Tong, Ron Ferguson, Jessica Liu, Birgit T. Priest, Barbara Pio, Yan Guo, Elizabeth Joshi, Nardos Teumelsan, Ling Xu, Martin Köhler, Joseph M. Metzger, Zach Guo, Kevin M. Maloney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1109-1114
A spirocyclic class of ROMK inhibitors was developed containing a structurally diverse heterocyclic sulfone moiety and spirocyclic core starting from lead 1. These compounds not only displayed exquisite ROMK potency but significantly improved selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c5ab8a2efa0d6babaaad56a9277a67
https://doi.org/10.1016/j.bmcl.2016.10.032
https://doi.org/10.1016/j.bmcl.2016.10.032
Autor:
Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5695-5702
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ba115f699ab80f9a1176691245bcc
https://doi.org/10.1016/j.bmcl.2016.10.064
https://doi.org/10.1016/j.bmcl.2016.10.064
Autor:
Benjamin Wilenkin, Brian J. Eastwood, Emanuele Sher, Birgit T. Priest, Andrew Caerwyn Williams, Kevin D. Burris
Publikováno v:
Assay and drug development technologies. 17(7)
Relief from chronic pain continues to represent a large unmet need. The voltage-gated potassium channel Kv7.2/7.3, also known as KCNQ2/3, is a key contributor to the control of resting membrane potential and excitability in nociceptive neurons and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4d1b91e38bd3e0557f0b0da078a9a3
https://pubmed.ncbi.nlm.nih.gov/31634018
https://pubmed.ncbi.nlm.nih.gov/31634018
Autor:
Dann L. Parker, Randal M. Bugianesi, Birgit T. Priest, Feroze Ujjainwalla, Edward C. Sherer, Stanley Mitelman, Sharon Tong, Matthew Lombardo, William K. Hagmann, Ravi P. Nargund, Melissa Costa, Christopher Joseph Sinz, Anka G. Ehrhardt, Scott D. Edmondson, Ravi Kurukulasuriya, Xiaofang Li, Karen H. Dingley, Kate Bender, Kevin S. Ratliff, Jonathan E. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2947-2951
A novel series of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists are described. The series was designed to address the suboptimal PK (pharmacokinetic) and off-target profile of a class of N-aryl-benzo-[1,4]-oxazepine-4-carboxamides, represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f4fd9aaf407b2d77d08816feb7cb20
https://doi.org/10.1016/j.bmcl.2016.04.018
https://doi.org/10.1016/j.bmcl.2016.04.018
Autor:
Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour
Publikováno v:
ACS Medicinal Chemistry Letters. 7:697-701
ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney nephron. Because of this dual site of action, selective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e7bac5379921d8eb6098d8804f901
https://doi.org/10.1021/acsmedchemlett.6b00122
https://doi.org/10.1021/acsmedchemlett.6b00122