Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Birgit Stierstorfer"'
Autor:
Lisa-Maria Winter, Diana Reinhardt, Ariane Schatter, Vivien Tissen, Heike Wiora, Daniel Gerlach, Ulrike Tontsch-Grunt, Florian Colbatzky, Birgit Stierstorfer, Seong-Wook Yun
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract GDF15 has recently emerged as a key driver of the development of various disease conditions including cancer cachexia. Not only the tumor itself but also adverse effects of chemotherapy have been reported to contribute to increased GDF15. Al
Externí odkaz:
https://doaj.org/article/824669cb47604d63b4686cf0ba92e957
Autor:
Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targe
Externí odkaz:
https://doaj.org/article/bfa18d4f4cb54bf398d1a6ddf489f5be
Autor:
Christian T. Wohnhaas, Kevin Baßler, Carolin K. Watson, Yang Shen, Germán G. Leparc, Cornelia Tilp, Fabian Heinemann, David Kind, Birgit Stierstorfer, Denis Delić, Thomas Brunner, Florian Gantner, Joachim L. Schultze, Coralie Viollet, Patrick Baum
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Smoking is a leading risk factor of chronic obstructive pulmonary disease (COPD), that is characterized by chronic lung inflammation, tissue remodeling and emphysema. Although inflammation is critical to COPD pathogenesis, the cellular and molecular
Externí odkaz:
https://doaj.org/article/63c91076861d42e1acc8a8990681ade0
Autor:
Fabian Heinemann, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, Anna Mae Diehl, Manal Abdelmalek, Martin C. Lenter, Steven S. Pullen, Paolo Guarnieri, Birgit Stierstorfer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form non-alcoholic steatohepatitis (NASH), and ultimately to cirrhosis or liver cancer.
Externí odkaz:
https://doaj.org/article/d03e21bdb66a47cf83dafba82490bd38
Autor:
Dalia Pakalniškytė, Tanja Schönberger, Benjamin Strobel, Birgit Stierstorfer, Thorsten Lamla, Michael Schuler, Martin Lenter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Transgenic animals with increased or abrogated target gene expression are powerful tools for drug discovery research. Here, we developed a CRISPR-based Rosa26-LSL-dCas9-VPR mouse model for targeted induction of endogenous gene expression usi
Externí odkaz:
https://doaj.org/article/5f71560143154c38951bffbfbcaeeb5e
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background One of the main diagnostic tools for lung diseases in humans is computed tomography (CT). A miniaturized version, micro-CT (μCT) is utilized to examine small rodents including mice. However, fully automated threshold-based segmen
Externí odkaz:
https://doaj.org/article/55ad3c546b0a46c9a10eddfa5333eac1
Autor:
Anouk Oldenburger, Gerald Birk, Marco Schlepütz, Andre Broermann, Birgit Stierstorfer, Steven S. Pullen, Jörg F. Rippmann
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Fibrotic processes in the liver of non‐alcoholic steatohepatitis (NASH) patients cause microcirculatory dysfunction in the organ which increases blood vessel resistance and causes portal hypertension. Assessing blood vessel function in the
Externí odkaz:
https://doaj.org/article/8d0ef998b8d645d1824e8fb9eae616b3
Autor:
Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Nancy Antoine, Firas Khattab, Bao-Khanh Lai, Davide Brusa, Birgit Stierstorfer, Holger Klein, Bilal Singh, Lucie Ruiz, Michael Pieper, Michael Mark, Pedro L. Herrera, Fiona M. Gribble, Frank Reimann, Anne Wojtusciszyn, Christophe Broca, Nano Rita, Lorenzo Piemonti, Patrick Gilon
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101071- (2020)
Objective: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i), or gliflozins, are anti-diabetic drugs that lower glycemia by promoting glucosuria, but they also stimulate endogenous glucose and ketone body production. The likely causes of the
Externí odkaz:
https://doaj.org/article/21bfada24dc04976b5da4c463b456525
Autor:
Christian T. Wohnhaas, Julia A. Gindele, Tobias Kiechle, Yang Shen, Germán G. Leparc, Birgit Stierstorfer, Heiko Stahl, Florian Gantner, Coralie Viollet, Jürgen Schymeinsky, Patrick Baum
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7646 (2021)
Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and causes remodeling of the small airways. However, the exact smoke-induced effects on the different types of small airway epithelial cells (SAECs) are poorly understood
Externí odkaz:
https://doaj.org/article/5e0261275bdc4ef19f1dee42fa254b76
Autor:
Andre Broermann, Ramona Schmid, Ogsen Gabrielyan, Marlene Sakowski, Claudia Eisele, Sascha Keller, Michael Wolff, Patrick Baum, Birgit Stierstorfer, Jochen Huber, Bernhard K. Krämer, Berthold Hocher, Ruediger Streicher, Denis Delić
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 382 (2020)
MicroRNAs (miRNAs) are short, non-coding RNA species that are important post-transcriptional regulators of gene expression and play an important role in the pathogenesis of non-alcoholic fatty liver disease. Here, we investigated the phosphodiesteras
Externí odkaz:
https://doaj.org/article/0e17b3d923254f18b7ac57924da415f5