Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Birgit Schittek"'
Autor:
Arnaud Kengmo Tchoupa, Ahmed M. A. Elsherbini, Justine Camus, Xiaoqing Fu, Xuanheng Hu, Oumayma Ghaneme, Lea Seibert, Marco Lebtig, Marieke A. Böcker, Anima Horlbeck, Stilianos P. Lambidis, Birgit Schittek, Dorothee Kretschmer, Michael Lämmerhofer, Andreas Peschel
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Long-chain fatty acids with antimicrobial properties are abundant on the skin and mucosal surfaces, where they are essential to restrict the proliferation of opportunistic pathogens such as Staphylococcus aureus. These antimicrobial fatty ac
Externí odkaz:
https://doaj.org/article/b8f6c51478b94aa5bdedbf00b5ad25d7
Autor:
Anne Berscheid, Jan Straetener, Nadine A. Schilling, Dominik Ruppelt, Martin C. Konnerth, Birgit Schittek, Bernhard Krismer, Andreas Peschel, Claudia Steinem, Stephanie Grond, Heike Brötz-Oesterhelt
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT Lugdunin is a microbiome-derived antibacterial agent with good activity against Gram-positive pathogens in vitro and in animal models of nose colonization and skin infection. We have previously shown that lugdunin depletes bacterial energy r
Externí odkaz:
https://doaj.org/article/eb6a7b58225045c58f79c187afaa8ca4
Autor:
Kathrin Singvogel, Birgit Schittek
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Many cancer-related deaths including melanoma result from metastases that develop months or years after the initial cancer therapy. Even the most effective drugs and immune therapies rarely eradicate all tumor cells. Instead, they strongly r
Externí odkaz:
https://doaj.org/article/8514c7aeea1f4e29b370b60ab83e7bcd
Autor:
Jule Focken, Birgit Schittek
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionStaphylococcus aureus (S. aureus) infection of the skin leads to a rapid initial innate immune response with keratinocytes in the epidermis as the initial sensors. Polymorphonuclear neutrophils (PMNs) are the first innate immune cells to
Externí odkaz:
https://doaj.org/article/65559cf63b6b4dd2905b293fae5e23eb
Autor:
Corinna Kosnopfel, Simone Wendlinger, Heike Niessner, Johannes Siewert, Tobias Sinnberg, Angelika Hofmann, Jonas Wohlfarth, David Schrama, Marion Berthold, Claudia Siedel, Birgit Sauer, Aarthi Jayanthan, Georg Lenz, Sandra E. Dunn, Bastian Schilling, Birgit Schittek
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an efficient treatment option for cases harboring BRAFV600 mutations (BRAFMut). H
Externí odkaz:
https://doaj.org/article/0723a98be8b54729b41f40fee5a42d27
Autor:
Jasmin Scheurer, Birgit Sauer, Jule Focken, Martina Giampetraglia, Annika Jäger, Christian M. Schürch, Bettina Weigelin, Birgit Schittek
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/b2e76f21dbe54f03bff62133e9c45c41
Autor:
Jule Focken, Jasmin Scheurer, Annika Jäger, Christian M. Schürch, Sofie Kämereit, Simon Riel, Martin Schaller, Bettina Weigelin, Birgit Schittek
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113148- (2023)
Summary: Staphylococcus aureus is the most common cause of bacterial skin infections in humans, including patients with atopic dermatitis (AD). Polymorphonuclear neutrophils (PMNs) are the first cells to infiltrate an infection site, where they usual
Externí odkaz:
https://doaj.org/article/18ee08d62d964e14bd212678ec2667c9
Autor:
Paola Maura Tricarico, Rossella Gratton, Carlos André dos Santos-Silva, Ronald Rodrigues de Moura, Blendi Ura, Eduardo Sommella, Pietro Campiglia, Cecilia Del Vecchio, Chiara Moltrasio, Irene Berti, Adamo Pio D’Adamo, Ahmed M. A. Elsherbini, Lena Staudenmaier, Karin Chersi, Michele Boniotto, Bernhard Krismer, Birgit Schittek, Sergio Crovella
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a multifactorial aetiology that involves a strict interplay between genetic factors, immune dysregulation and lifestyle. Familial forms represent around 40% of total HS cases a
Externí odkaz:
https://doaj.org/article/740e2dbb8d4044e9a29db2dee3e8cb1d
Autor:
Katharina Bitschar, Birgit Sauer, Jule Focken, Hanna Dehmer, Sonja Moos, Martin Konnerth, Nadine A. Schilling, Stephanie Grond, Hubert Kalbacher, Florian C. Kurschus, Friedrich Götz, Bernhard Krismer, Andreas Peschel, Birgit Schittek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Lugdunin is a peptide antibiotic produced by the skin commensal Staphylococcus lugdunensis. Here, the authors show that lugdunin reduces Staphylococcus aureus colonization in human keratinocytes and mouse skin by inducing the expression of human LL-3
Externí odkaz:
https://doaj.org/article/cdeeef7531844cd4aa56780138aa628c
Autor:
Tobias Sinnberg, Elena Makino, Marcel A. Krueger, Ana Velic, Boris Macek, Ulrich Rothbauer, Nicola Groll, Oliver Pötz, Stefan Czemmel, Heike Niessner, Friedegund Meier, Kristian Ikenberg, Claus Garbe, Birgit Schittek
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 132-149 (2016)
Acquired resistance to second generation BRAF inhibitors (BRAFis), like vemurafenib is limiting the benefits of long term targeted therapy for patients with malignant melanomas that harbor BRAF V600 mutations. Since many resistance mechanisms have be
Externí odkaz:
https://doaj.org/article/2e1b05dd00f64c71ac1a7708866ee974