Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Birgit Schiøtt"'
Autor:
Elad Arad, Kasper B. Pedersen, Orit Malka, Sisira Mambram Kunnath, Nimrod Golan, Polina Aibinder, Birgit Schiøtt, Hanna Rapaport, Meytal Landau, Raz Jelinek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Antibiotic resistance of bacteria is considered one of the most alarming developments in modern medicine. While varied pathways for bacteria acquiring antibiotic resistance have been identified, there still are open questions concerning the
Externí odkaz:
https://doaj.org/article/2e6f4b67c7264031b3ec5edb8e5ec825
Autor:
Steven J. Roeters, Kris Strunge, Kasper B. Pedersen, Thaddeus W. Golbek, Mikkel Bregnhøj, Yuge Zhang, Yin Wang, Mingdong Dong, Janni Nielsen, Daniel E. Otzen, Birgit Schiøtt, Tobias Weidner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The amyloid aggregation of α-synuclein (αS), related to Parkinson’s disease, can be catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and orientation of lipid-bound αS is still not known in detail.
Externí odkaz:
https://doaj.org/article/e2c70aa70bdf4978bba2517cd5c5812f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The human dopamine transporter (hDAT) is one in three members of the monoamine transporter family (MAT). hDAT is essential for regulating the dopamine concentration in the synaptic cleft through dopamine reuptake into the presynaptic neuron;
Externí odkaz:
https://doaj.org/article/8672ebf9631d40e4bbb79de58c8abfae
Autor:
Mikkel Vestergaard, Nils Anton Berglund, Pin-Chia Hsu, Chen Song, Heidi Koldsø, Birgit Schiøtt, Mark S. P. Sansom
Publikováno v:
ACS Omega, Vol 4, Iss 20, Pp 18889-18899 (2019)
Externí odkaz:
https://doaj.org/article/2800c97b623748a18240b3c4f85c8be3
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation. Cholesterol is prese
Externí odkaz:
https://doaj.org/article/4d0e81fc59c54a07bd64be52dd95be0e
Autor:
Tone Bengtsen, Viktor L Holm, Lisbeth Ravnkilde Kjølbye, Søren R Midtgaard, Nicolai Tidemand Johansen, Giulio Tesei, Sandro Bottaro, Birgit Schiøtt, Lise Arleth, Kresten Lindorff-Larsen
Publikováno v:
eLife, Vol 9 (2020)
Nanodiscs are membrane mimetics that consist of a protein belt surrounding a lipid bilayer, and are broadly used for characterization of membrane proteins. Here, we investigate the structure, dynamics and biophysical properties of two small nanodiscs
Externí odkaz:
https://doaj.org/article/a171d85d99464a76b087a8e0b6ca30d5
Autor:
Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt, Steffen Sinning, Poul Nissen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Neurotransmitter:sodium symporters (NSS) perform Na+-dependent amino-acid uptake, but a full structural description of their function is lacking. Here the authors present a structure of the bacterial NSS LeuT in the outward-oriented empty state and s
Externí odkaz:
https://doaj.org/article/0c4dfaf71bb84eee82b29dd34e8c741a
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005907 (2018)
Monoamine transporters (MATs) carry out neurotransmitter reuptake from the synaptic cleft, a key step in neurotransmission, which is targeted in the treatment of neurological disorders. Cholesterol (CHOL), a major component of the synaptic plasma mem
Externí odkaz:
https://doaj.org/article/3d3c0ed49bf24cddafe0f27de81be7ee
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63635 (2013)
The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter. It has been shown from accessibility experiments that cocaine mainly induces an outward-facing con
Externí odkaz:
https://doaj.org/article/15852a9b59a946118bd49b838b5e7238
Autor:
Heidi Koldsø, Pernille Noer, Julie Grouleff, Henriette Elisabeth Autzen, Steffen Sinning, Birgit Schiøtt
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002246 (2011)
Monoamine transporters are responsible for termination of synaptic signaling and are involved in depression, control of appetite, and anxiety amongst other neurological processes. Despite extensive efforts, the structures of the monoamine transporter
Externí odkaz:
https://doaj.org/article/ea615afbb6e44450ad5101ad34d9c062