Mitochondrial Protein Sorting

Autor: Michael Rissler, Nils Wiedemann, Andreas Strub, Dusanka Milenkovic, Vera Kozjak, Chris Meisinger, Birgit Schönfisch, Hanne Müller, Nikolaus Pfanner

Publikováno v: Journal of Biological Chemistry. 281:22819-22826

The mitochondrial outer membrane contains two distinct machineries for protein import and protein sorting that function in a sequential manner: the general translocase of the outer membrane (TOM complex) and the sorting and assembly machinery (SAM co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab55c767a93c87aee7fc5bc1970c9b23
https://doi.org/10.1074/jbc.m602679200

Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase

Autor: Angelika B, Harbauer, Magdalena, Opalińska, Carolin, Gerbeth, Josip S, Herman, Sanjana, Rao, Birgit, Schönfisch, Bernard, Guiard, Oliver, Schmidt, Nikolaus, Pfanner, Chris, Meisinger

Publikováno v: Science (New York, N.Y.). 346(6213)

Mitochondria play central roles in cellular energy conversion, metabolism, and apoptosis. Mitochondria import more than 1000 different proteins from the cytosol. It is unknown if the mitochondrial protein import machinery is connected to the cell div

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76b14721da1a26f9aab97e97ed7f8b80
https://pubmed.ncbi.nlm.nih.gov/25602310

Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import

Autor: Nikolaus Pfanner, Oliver Schmidt, Bernard Guiard, Sanjana Rao, Chris Meisinger, Birgit Schönfisch, Angelika B. Harbauer

Publikováno v: Molecular Biology of the Cell

The translocase of the outer mitochondrial membrane (TOM) is essential for the import of proteins into mitochondria. Cytosolic protein kinase A phosphorylates the precursor of the channel-forming protein Tom40 and inhibits its import into mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4f8f24dd9f4d228414c429d7a32c8d
https://pubmed.ncbi.nlm.nih.gov/22419819

Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins

Autor: René P. Zahedi, Chris Meisinger, Bernard Guiard, Nikolaus Pfanner, Christiane Winkler, Andreas M. Boehm, Birgit Schönfisch, Nicole Zufall, Albert Sickmann

Publikováno v: Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2006, 17 (3), pp.1436-50. ⟨10.1091/mbc.E05-08-0740⟩
ResearcherID

Mitochondria consist of four compartments–outer membrane, intermembrane space, inner membrane, and matrix—with crucial but distinct functions for numerous cellular processes. A comprehensive characterization of the proteome of an individual mitoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418a2fc95ca7370366c2d3c77f94399f
https://hal.archives-ouvertes.fr/hal-00168063

Biogenesis of the yeast frataxin homolog Yfh1p. Tim44-dependent transfer to mtHsp70 facilitates folding of newly imported proteins in mitochondria

Autor: Joachim Rassow, Birgit Schönfisch, Andreas Geissler, Thomas Krimmer, Michiel Meijer

Publikováno v: European journal of biochemistry. 267(11)

Tim44 is an essential component of the mitochondrial inner membrane protein import machinery. In this study we asked if Tim44 is of relevance in intramitochondrial protein folding. We investigated the role of Tim44 in the biogenesis of the authentic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ccdec7ae598c05833bd41d092a931e
https://pubmed.ncbi.nlm.nih.gov/10824101