Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Birgit Real"'
Autor:
Antje Sucker, Fang Zhao, Natalia Pieper, Christina Heeke, Raffaela Maltaner, Nadine Stadtler, Birgit Real, Nicola Bielefeld, Sebastian Howe, Benjamin Weide, Ralf Gutzmer, Jochen Utikal, Carmen Loquai, Helen Gogas, Ludger Klein-Hitpass, Michael Zeschnigk, Astrid M. Westendorf, Mirko Trilling, Susanne Horn, Bastian Schilling, Dirk Schadendorf, Klaus G. Griewank, Annette Paschen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
IFNγ secretion by CD8+T cells is critical for immunotherapy efficacy. In this study, the authors show that melanoma patients can become resistant to immunotherapy by acquiring chromosomal alterations and subsequent inactivating mutations in genes of
Externí odkaz:
https://doaj.org/article/7dba103f7a864f4c8cb9130aa2e816d2
Autor:
Annette Paschen, Klaus Griewank, Christine S. Falk, Dirk Schadendorf, Soldano Ferrone, Matthias Kloor, Volker Lennerz, Francesco Sabbatino, Bastian Schilling, Peter A. Horn, Raffaela Maltaner, Iris Moll, Susanne Horn, Stefan Maβen, Nicola Bielefeld, Christina Heeke, Birgit Real, Fang Zhao, Antje Sucker
Supplementary Fig. S2. The different Ma-Mel-48 cell lines were treated with IFN-γ (500 U/ml) for 48 h, controls were left untreated. Cells were stained with mAb L243 and mAb W6/32 for detection of HLA-DR and HLA class I antigen expression, respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e4e3ded057e02914eec918d38d5f6d
https://doi.org/10.1158/1078-0432.22457960.v1
https://doi.org/10.1158/1078-0432.22457960.v1
Autor:
Annette Paschen, Klaus Griewank, Christine S. Falk, Dirk Schadendorf, Soldano Ferrone, Matthias Kloor, Volker Lennerz, Francesco Sabbatino, Bastian Schilling, Peter A. Horn, Raffaela Maltaner, Iris Moll, Susanne Horn, Stefan Maβen, Nicola Bielefeld, Christina Heeke, Birgit Real, Fang Zhao, Antje Sucker
Purpose: CD8+ T lymphocytes can kill autologous melanoma cells, but their activity is impaired when poorly immunogenic tumor phenotypes evolve in the course of disease progression. Here, we analyzed three consecutive melanoma lesions obtained within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f580396756b9787f63605506934c2be
https://doi.org/10.1158/1078-0432.c.6523766.v1
https://doi.org/10.1158/1078-0432.c.6523766.v1
Autor:
Annette Paschen, Fang Zhao, Susanne Horn, Helen Gogas, Dirk Schadendorf, Benjamin Weide, Antje Sucker, Bastian Schilling, Jochen Utikal, Carmen Loquai, Ludger Klein-Hitpass, Nadine Stadtler, Raffaela Maltaner, Michael Zeschnigk, Nicola Bielefeld, Astrid M. Westendorf, Birgit Real, Natalia Pieper, Christina Heeke, Ralf Gutzmer, Mirko Trilling, Klaus G. Griewank, Sebastian Howe
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8+ T cells is critical for therapy efficacy having anti-proliferative and pro-apoptotic effects on tumour cells. Our study demonstrates a genetic evolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4cfe1b9a8a6acb58788bf15c62d90f
https://doi.org/10.1038/ncomms15440
https://doi.org/10.1038/ncomms15440
Autor:
Soldano Ferrone, Susanne Horn, Fang Zhao, Antje Sucker, Christine S. Falk, Iris Moll, Nicola Bielefeld, Birgit Real, Christina Heeke, Raffaela Maltaner, Bastian Schilling, Francesco Sabbatino, Stefan Maβen, Volker Lennerz, Peter A. Horn, Dirk Schadendorf, Matthias Kloor, Annette Paschen, Klaus G. Griewank
Publikováno v:
Clin Cancer Res
Purpose: CD8+ T lymphocytes can kill autologous melanoma cells, but their activity is impaired when poorly immunogenic tumor phenotypes evolve in the course of disease progression. Here, we analyzed three consecutive melanoma lesions obtained within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d8cfc11f509c13395a4d9e688806aa
http://hdl.handle.net/11386/4707640
http://hdl.handle.net/11386/4707640