Increased adiposity and reduced adipose tissue mRNA expression of uncoupling protein-2 in first-degree relatives of type 2 diabetic patients: evidence for insulin stimulation of UCP-2 and UCP-3 gene expression in adipose tissue

Autor: Bjørn Richelsen, Michael F. Nielsen, Ole Schmitz, Kurt Kristensen, Birgit Nyholm, Steen B. Pedersen

Publikováno v: Pedersen, S B, Nyholm, B, Kristensen, K, Nielsen, M F, Schmitz, O & Richelsen, B 2005, ' Increased adiposity and reduced adipose tissue mRNA expression of uncoupling protein-2 in first-degree relatives of type 2 diabetic patients : evidence for insulin stimulation of UCP-2 and UCP-3 gene expression in adipose tissue ', Diabetes, Obesity and Metabolism Online, vol. 7, no. 1, pp. 98-105 . https://doi.org/10.1111/j.1463-1326.2005.00365.x

The mitochondrial uncoupling proteins (UCP-2 and UCP-3), which have been suggested to be involved in the development of obesity by controlling the energy expenditure (EE), were studied in 22 healthy first-degree relatives (FDRs) of patients with type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0cd53f838e0b48453af73be5d3a9f4
https://doi.org/10.1111/j.1463-1326.2005.00365.x

Amylin receptor agonists: a novel pharmacological approach in the management of insulin-treated diabetes mellitus

Autor: Birgit Nyholm, L. Ørskov, Birgitte Brock, Ole Schmitz

Publikováno v: Expert Opinion on Investigational Drugs. 10:1641-1652

Amylin is a peptide hormone which is co-secreted with insulin from the pancreatic beta-cell. Type 1 diabetic individuals and some Type 2 diabetic individuals are characterised by amylin deficiency. Animal experiments have revealed several actions of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefda3ac86c1f870be8aaad8dace76e8
https://doi.org/10.1517/13543784.10.9.1641

No seasonal variation of insulin sensitivity and glucose effectiveness in men

Autor: Mogens Erlandsen, Ole Schmitz, Birgit Nyholm, Claus Højbjerg Gravholt, Palle Holck, Erik Christiansen

Publikováno v: Metabolism. 49:32-38

Insulin resistance is of pathogenetic importance for the development of non-insulin-dependent diabetes mellitus (NIDDM). However, not much is known about the variation in insulin sensitivity in the individual over longer periods. Consequently, we mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404edf10a2f0fd976c683e99875492d3
https://doi.org/10.1016/s0026-0495(00)90613-9

The Effect of Two Frequent Amino Acid Variants of the Hepatocyte Nuclear Factor-1α Gene on Estimates of the Pancreatic β-Cell Function in Caucasian Glucose-Tolerant First-Degree Relatives of Type 2 Diabetic Patients1

Autor: Torben Hansen, Hans Eiberg, Jesper O. Clausen, Claus Thorn Ekstrøm, AM Moller, Ole Schmitz, Oluf Pedersen, Søren A. Urhammer, Birgit Nyholm

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 83:3992-3995

The objective of the present study was to investigate whether the frequent amino acid polymorphisms, Ile/Leu27 and Ser/Asn487, of the hepatocyte nuclear factor-1alpha gene were associated with alterations in glucose-induced serum C-peptide and serum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e6f4554e438d8ddb0b29b8b561b510e
https://doi.org/10.1210/jcem.83.11.5228

Effects of Amylin and the Amylin Agonist Pramlintide on Glucose Metabolism

Autor: Birgit Nyholm, Niels Møller, Ole Schmitz, L. Ørskov, Claus Højbjerg Gravholt

Publikováno v: Diabetic Medicine. 14:S19-S23

Since the discovery of the pancreatic islet hormone amylin in 1987, its metabolic effects have been investigated in a number of studies in animals and humans. Data from some early animal studies suggested that amylin might be associated with the deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad429f9c62547a0ce72ca41a297b5e3c
https://doi.org/10.1002/(sici)1096-9136(199706)14:2+3.0.co